生物活性

• 描述Meclofenamate Sodium (MS) is an nonsteroidal anti-inflammatory drugs (NSAIDs) used to reduce pain. Addition of exogenous proteasome to MS treated cells improved cell viability^[2]. Single 100- and 200-mg doses of meclofenamate sodium are as safe as, and significantly more effective than, codeine 60 mg or placebo for episiotomy pain^[3]. In the majority of patients (headache and craniofacial pain), the meclofenamate sodium period scored lowest or second-lowest after the follow-up period in mean pain intensity^[4]. Meclofenamate sodium in the dose administered was equally effective in relieving pain and inflammation and restoring restricted function in patients with acute gout as indometacin when used in the generally recommended dose for this indication. Meclofenamate sodium, even at these high dosage levels, was better tolerated than indometacin^[5]. Similar improvement in mobility of the vertebral column and spondylitic pain could be achieved with meclofenamate sodium and indometacin in patients with ankylosing spondylitis. Meclofenamate sodium offers an effective and safe alternative to indometacin in the treatment of patients with ankylosing spondylitis^[6].
• 临床研究

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• 参考文献

• [1] Eleftheriou CG, Cehajic-Kapetanovic J, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopic expression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345.

  [2] Ghosh R, Hwang SM, Cui Z, Gilda JE, Gomes AV. Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells. J Mol Cell Cardiol. 2016;94:131-144

  [3] Hebertson RM, Storey N, Turner JL. Analgesic efficacy of meclofenamate sodium in episiotomy pain. Pharmacotherapy. 1986;6(5):205-210

  [4] Mongini F, Bona G, Garnero M, Gioria A. Efficacy of meclofenamate sodium versus placebo in headache and craniofacial pain. Headache. 1993;33(1):22-28

  [5] Eberl R, Dunky A. Meclofenamate sodium in the treatment of acute gout. Results of a double-blind study. Arzneimittelforschung. 1983;33(4A):641-643

  [6] Ebner W, Poal Ballarin JM, Boussina I. Meclofenamate sodium in the treatment of ankylosing spondylitis. Report of a European double-blind controlled multicenter study. Arzneimittelforschung.1983;33(4A):660-663

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