|4-((7-(((2R,3R,4S,5R)-4-(氨甲酰氧基)-3-羟基-5-甲氧基-6,6-二甲基四氢-2H-吡喃-2-基)氧基)-4-羟基-8-甲基-2-氧代-2H-苯并吡喃-3-基)氨甲酰基)-2-(3-甲基-2-烯-1-基)酚酸钠|CsnPharm

CAS No.: 1476-53-5

新生霉素（钠盐） Catalog No. CSN11583

Synonyms: Albamycin sodium;Cathomycin sodium;Albamycin

Novobiocin sodium is an antibiotic that derived from Streptomyces niveus.

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技术信息

生物活性

描述Novobiocin is an orally active antibiotic that inhibits DNA gyrase by binding the ATP-binding site in the ATPase subunit^[3]. Novobiocin not only inhibits DNA gyrase but also binds and stimulates LptB, the ATPase that powers LPS transport^[4]. Novobiocin, an old antibiotic, was tested in vitro and in a murine sepsis model against one amoxicillin-susceptible and three amoxicillin-resistant strains (minimum inhibitory concentrations (MICs) 8-64 mg/L)^[5]. Novobiocin is shown to inhibit melanoma B16 cell proliferation. Growth inhibition by novobiocin was accompanied by phenotypic alterations, that included morphological changes, lipid accumulation and marked increases in the activities of NADPH cytochrome c reductase and gamma glutamyl transpeptidase^[6]. Novobiocin, a HSP90 inhibitor, could decrease the expression of SMYD3 (SET and MYND domain-containing protein 3) and dose dependently inhibit the proliferation and migration of MDA-MB-231 human breast cancer cells^[7]. Novobiocin and cDDP (cisplatin) or BCNU (carmustine) markedly reduced in vivo growth of a murine fibrosarcoma without increased host toxicity^[8].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... more >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu Sub-Investigator: Forest Arnold, DO Sub-Investigator: Timothy Wiemkwn, PhD Sub-Investigator: Robert Kelley, PhD Sub-Investigator: James Summersgill, PhD Sub-Investigator: Ruth Carrico, PhD Sub-Investigator: Julie Harting, PharmD Sub-Investigator: Paula Peyrani, MD Principal Investigator: David Seligson, MD Sub-Investigator: Craig Roberts, MD Principal Investigator: Julio Ramirez, MD Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.5758 mL
- 7.8789 mL
- 15.7578 mL
- 5 mM
- 0.3152 mL
- 1.5758 mL
- 3.1516 mL
- 10 mM
- 0.1576 mL
- 0.7879 mL
- 1.5758 mL

技术信息

CAS号

1476-53-5

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C31H35N2NaO11

运输

蓝冰

分子量

634.61

别名

Albamycin sodium;Cathomycin sodium;Albamycin;Novobiocin (sodium salt);NSC 2382;Albadry;Novobiocin monosodium salt;Cardelmycin sodium salt;Cathomycin;Inabiocin;Monosodium novobiocin;Novobiocin monosodium;Novobiocin natrium;Sodium albamycin;Sodium novobiocin;Streptonivicin sodium salt;U-6591;Vulcamycin;新生霉素钠

溶解度

DMSO	99.0 mg/mL (156.0 mM)
Water	98.0 mg/mL (154.4 mM)
Ethanol	98.0 mg/mL (154.4 mM)

动物实验配方

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新生霉素（钠盐） Catalog No. CSN11583

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