CAS No.: 1716-12-7
苯丁酸钠 Catalog No. CSN11942
Synonyms: 4-PBA sodium;4-Phenylbutyric acid sodium;Benzenebutyric acid sodium
Sodium 4-phenylbutyrate is an inhibitor of histone deacetylase that has been used to treat urea cycle disorders.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 细胞研究
- Cell Data
- 更多
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00999167 Cirrhosis Hep... more >>atic Encephalopathy Collapse << Phase 2 Completed - - NCT01135680 Drug Toxicity Phase 1 Completed - United States, Wisconsin ... more >> Covance Clinical Pharmacology, Inc. Madison, Wisconsin, United States, 53704 Collapse << NCT00999167 - - Completed - - - 更多
- 参考文献
- [1] Gardian G, Yang L, Cleren C, Calingasan NY, Klivenyi P, Beal MF. Neuroprotective effects of phenylbutyrate against MPTP neurotoxicity. Neuromolecular Med. 2004;5(3):235-41.
- [2] Goh M, Chen F, Paulsen MT, Yeager AM, Dyer ES, Ljungman M. Phenylbutyrate attenuates the expression of Bcl-X(L), DNA-PK, caveolin-1, and VEGF in prostate cancer cells. Neoplasia. 2001 Jul-Aug;3(4):331-8.
- [3] Wang CT, Meng M, Zhang JC, Jin CJ, Jiang JJ, Ren HS, Jiang JM, Qin CY, Yu DQ. Growth inhibition and gene induction in human hepatocellular carcinoma cell exposed to sodium 4-phenylbutanoate. Chin Med J (Engl). 2008 Sep 5;121(17):1707-11
- [4] Qi X, Hosoi T, Okuma Y, Kaneko M, Nomura Y. Sodium 4-phenylbutyrate protects against cerebral ischemic injury. Mol Pharmacol. 2004 Oct;66(4):899-908
- [5] Yam GH, Gaplovska-Kysela K, Zuber C, Roth J. Sodium 4-phenylbutyrate acts as a chemical chaperone on misfolded myocilin to rescue cells from endoplasmic reticulum stress and apoptosis. Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1683-90
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1716-12-7 | 储存条件 |
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| 分子式 | C10H11NaO2 | 运输 | 蓝冰 | |||||
| 分子量 | 186.18 | 别名 | 4-PBA sodium;4-Phenylbutyric acid sodium;Benzenebutyric acid sodium;TriButyrate;Sodium phenylbutyrate;Sodium 4-Phenylbutyrate;Benzenebutanoic Acid;NSC 657802;4-phenylbutyrate (4-PBA);4-phenylbutyric acid;Buphenyl;苯丁酸钠 | |||||
| 溶解度 |
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动物实验配方 |
| Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
|---|
| A498 cells | 4 mM | Function assay | 8-48 h | Induction of CAMP mRNA expression in human A498 cells at 4 mM after 8 to 48 hrs by RT-PCR analysis | 19770273 |
| Hela cells | - | Function assay | - | Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assay | 19520580 |
| HT-29 cells | 4 mM | Function assay | 8-48 h | Induction of CAMP mRNA expression in human HT-29 cells at 4 mM after 8 to 48 hrs by RT-PCR analysis | 19770273 |
| U937 cells | 4 mM | Function assay | 8-48 h | Induction of CAMP mRNA expression in human U937 cells at 4 mM after 8 to 48 hrs by RT-PCR analysis | 19770273 |
| VA10 cells | - | Function assay | - | Induction of LL-37 protein expression in human VA10 cells at 20 nM after 24 hrs by Western blotting | 19770273 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT00999167 | Cirrhosis Hep... more >>atic Encephalopathy Collapse << | Phase 2 | Completed | - | - |
| NCT01135680 | Drug Toxicity | Phase 1 | Completed | - | United States, Wisconsin ... more >> Covance Clinical Pharmacology, Inc. Madison, Wisconsin, United States, 53704 Collapse << |
| NCT00999167 | - | - | Completed | - | - |
| NCT01347073 | Urea Cycle Disorders | Phase 3 | Completed | - | United States, California ... more >> UCLA Pediatrics/Genetics Los Angeles, California, United States, 90404 United States, District of Columbia Children's National Medical Center Washington, District of Columbia, United States, 20010 United States, Maine Maine Medical Center Portland, Maine, United States, 04101 United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States, 55455 United States, New York Mount Sinai School of Medicine New York, New York, United States, 10029 United States, Ohio University Hospitals Case Medical Center Cleveland, Ohio, United States, 44106 United States, Oregon Oregon Health & Science University Portland, Oregon, United States, 97239 United States, Texas Baylor College of Medicine Houston, Texas, United States, 77030 Collapse << |
| NCT01948427 | - | - | Recruiting | September 2026 | United States, Pennsylvania ... more >> United BioSource Corporation Recruiting Blue Bell, Pennsylvania, United States, 19422 Contact: THRIVE Registry Team 855-823-2595 thriveregistry@unitedbiosource.com Collapse << |
| NCT03488524 | Amyotrophic Lateral Sclerosis ... more >> ALS Collapse << | Phase 2 | Recruiting | January 1, 2020 | United States, Massachusetts ... more >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Aileen Shaughnessy, MA 617-724-9196 ANSHAUGHNESSY@mgh.harvard.edu Principal Investigator: James Berry, MD University of Massachusetts Memorial Medical Center Recruiting Worcester, Massachusetts, United States, 01655 Contact: Diane McKenna-Yasek, RN, BSN 508-856-4697 diane.mckenna-yasek@umassmed.edu Principal Investigator: Margaret Owegi, DO Collapse << |
| NCT00067756 | Alpha 1-Antitrypsin Deficiency | Phase 2 | Completed | - | United States, Florida ... more >> University of Florida Gainesville, Florida, United States, 32610 Collapse << |
| NCT02094222 | - | - | - | - | - |
| NCT00947297 | - | - | Completed | - | - |
| NCT00771901 | - | - | Completed | - | - |
| NCT01347073 | - | - | Completed | - | - |
| NCT01257737 | Urea Cycle Disorders | Phase 4 | Completed | - | United States, California ... more >> UCLA Pediatrics/Genetics Los Angeles, California, United States, 90095 Stanford University School of Medicine Palo Alto, California, United States, 94305 United States, Colorado Denver Children's Hospital Aurora, Colorado, United States, 80045 United States, District of Columbia Children's National Medical Center Washington, District of Columbia, United States, 20010 United States, Maine Maine Medical Center Portland, Maine, United States, 04102 United States, Minnesota University of Minnesota Medical Center Minneapolis, Minnesota, United States, 55454 United States, New York Mount Sinai School of Medicine New York, New York, United States, 10029 United States, Ohio University Hospitals Case Medical Center Cleveland, Ohio, United States, 44106 Nationwide Children's Hospital Columbus, Ohio, United States, 43205 United States, Oregon Oregon Health & Science University Portland, Oregon, United States, 97239 United States, Pennsylvania Children's Hospital of Pittsburg of UPMC Pittsburgh, Pennsylvania, United States, 15224 United States, Texas Baylor College of Medicine Houston, Texas, United States, 77030 United States, Utah University of Utah Salt Lake City, Utah, United States, 84112 United States, Washington Seattle Children's Hospital Seattle, Washington, United States, 98105 United States, Wisconsin Children's Hospital of Wisconsin Milwaukee, Wisconsin, United States, 53226 Canada, Ontario The Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8 Collapse << |
| NCT00771901 | Insulin Resistance ... more >> Diabetes Obesity Collapse << | Not Applicable | Completed | - | United States, Missouri ... more >> Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Collapse << |
| NCT00004767 | Amino Acid Metabolism, Inborn ... more >>Errors Collapse << | Phase 2 | Completed | - | - |
| NCT00947297 | Urea Cycle Disorders | Phase 3 | Completed | - | - |
| NCT03533257 | Alzheimer Disease | Phase 2 | Recruiting | September 1, 2020 | United States, Illinois ... more >> Rush University Medical Center Recruiting Chicago, Illinois, United States, 60612 Contact: Judy Phillips 312-942-0050 Judy_Phillips@rush.edu United States, Kansas University of Kansas Clinical Research Center Recruiting Fairway, Kansas, United States, 66205 Contact: KUMC Recruitment Division 913-588-0555 KUAMP@kumc.edu United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Alison J McManus, DNP 617-643-4848 ajmcmanus@mgh.harvard.edu Contact: John Ernandez 617-643-4047 jernandez@partners.org United States, New Jersey Rowan University Not yet recruiting Stratford, New Jersey, United States, 08084 Contact: Lauren Fedor 856-566-6003 fedor@rowan.edu United States, New York Mount Sinai Alzheimer's Disease Research Center Not yet recruiting New York, New York, United States, 10029 Contact: Caroline Meuser 212-659-8885 caroline.meuser@mssm.edu Columbia University Recruiting New York, New York, United States, 10032 Contact: Ruth Tejeda 212-305-7661 rbt41@cumc.columbia.edu United States, Pennsylvania Penn Memory Center Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Laura Schankel 215-349-8727 laura.schankel@pennmedicine.upenn.edu Collapse << |
| NCT00006239 | Leukemia Myel... more >>odysplastic Syndromes Myelodysplastic/Myeloproliferative Diseases Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231-2410 Collapse << |
| NCT01257737 | - | - | Completed | - | - |
| NCT00986895 | Hepatic Encephalopathy ... more >> Urea Cycle Disorders Collapse << | Phase 1 | Completed | - | Ukraine ... more >> National University of Pharmacy Kharkiv, Ukraine, 61057 Department of General Surgery #2; Kharkiv State Medical University Kharkiv, Ukraine, 61128 Collapse << |
| NCT00387530 | Gastric Cancer ... more >> Head and Neck Cancer Lymphoma Lymphoproliferative Disorder Collapse << | Phase 2 | Unknown | - | United States, California ... more >> Rebecca and John Moores UCSD Cancer Center La Jolla, California, United States, 92093-0658 Collapse << |
| NCT00005934 | Beta Thalassemia | Phase 2 | Completed | - | United States, Maryland ... more >> National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Bethesda, Maryland, United States, 20892 Collapse << |
| NCT03127514 | Amyotrophic Lateral Sclerosis ... more >> Motor Neuron Disease Neuromuscular Diseases Neurodegenerative Diseases Spinal Cord Diseases TDP-43 Proteinopathies Nervous System Diseases Central Nervous System Diseases Collapse << | Phase 2 | Recruiting | May 2019 | - |
| NCT02343094 | Proteinuric Diseases | Phase 2 Phase 3 | Completed | - | France ... more >> Hôpital Necker Enfants Malades Paris, France, 75015 Collapse << |
| NCT02246218 | Urea Cycle Disorder | Phase 4 | Completed | - | United States, California ... more >> Kaiser Permanente Regional Metabolic Center Los Angeles, California, United States, 90027 Stanford Center for Clinical & Translational Research & Education Palo Alto, California, United States, 94034 United States, District of Columbia Children's National Medical Center Washington, D.C., District of Columbia, United States, 20010 United States, Florida Shands at University of Florida Gainesville, Florida, United States, 32610 United States, Georgia Emory University Decatur, Georgia, United States, 30033 United States, Indiana Indiana University Indianapolis, Indiana, United States, 46202 United States, Maine Maine Medical Center Portland, Maine, United States, 04102 United States, Michigan Children's Hospital of Michigan Detroit, Michigan, United States, 48201 United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States, 55455 United States, New York Mount Sinai School of Medicine New York, New York, United States, 10029 United States, Ohio University Hospitals Case Medical Center Cleveland, Ohio, United States, 44106 United States, Oregon Oregon Health & Science University Portland, Oregon, United States, 97239 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Children's Hospital of Pittsburgh Pittsburgh, Pennsylvania, United States, 15224 United States, Utah University of Utah Salt Lake City, Utah, United States, 84132 United States, Washington Seattle Children's Hospital Seattle, Washington, United States, 98105 Canada The Hospital for Sick Children Toronto, Canada, M5G 1Hs Collapse << |
| NCT00006240 | Leukemia | Phase 2 | Completed | - | United States, Maryland ... more >> Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support Bethesda, Maryland, United States, 20892-1182 National Heart, Lung, and Blood Institute Bethesda, Maryland, United States, 20892 United States, New York Mount Sinai Medical Center, NY New York, New York, United States, 10029 United States, Pennsylvania University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania, United States, 15213-3489 Collapse << |
| NCT00005639 | Lymphoma Smal... more >>l Intestine Cancer Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231 Collapse << |
| NCT01881984 | Medium-chain Acyl-CoA Dehydrog... more >>enase (MCAD) Deficiency Collapse << | Phase 1 | Completed | - | United States, Pennsylvania ... more >> Children's Hospital of Pittsburgh of UPMC Pittsburgh, Pennsylvania, United States, 15224 Collapse << |
| NCT00006019 | Leukemia Lung... more >> Cancer Lymphoma Multiple Myeloma and Plasma Cell Neoplasm Myelodysplastic Syndromes Prostate Cancer Collapse << | Phase 2 | Completed | - | United States, New York ... more >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Collapse << |
| NCT02323100 | Cystic Fibrosis | Phase 1 Phase 2 | Recruiting | April 2020 | United States, Alabama ... more >> University of Alabama at Birmingham Not yet recruiting Birmingham, Alabama, United States, 35294-0006 Contact: Steven M Rowe, MD, MSPH 205-934-9640 smrowe@uab.edu Principal Investigator: Steven M Rowe, MD, MSPH United States, Colorado National Jewish Health Recruiting Denver, Colorado, United States, 80206 Contact: Connie StClair 303-270-2321 shiven@njhealth.org Principal Investigator: Noah Lechtzin, MD Sub-Investigator: Peter Mogazel, MD, PhD United States, Pennsylvania Children's Hospital of Philadelphia Not yet recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Ron Rubenstein, MD, PhD 215-590-1281 rrubenst@mail.med.upenn.edu Principal Investigator: Ron Rubenstein, MD, PhD Collapse << |
| NCT00016744 | Cystic Fibrosis | Phase 1 Phase 2 | Completed | - | - |
| NCT01881984 | - | - | Completed | - | - |
| NCT00006450 | Brain Tumor | Phase 2 | Completed | - | United States, Maryland ... more >> National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 Collapse << |
| NCT00590538 | - | - | Terminated(12/15/2008 Voluntar... more >>ily placed on inactive status-requested by the PI) Collapse << | - | - |
| NCT00590538 | Cystic Fibrosis | Phase 1 Phase 2 | Terminated(12/15/2008 Voluntar... more >>ily placed on inactive status-requested by the PI) Collapse << | - | United States, Pennsylvania ... more >> The Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Collapse << |
| NCT00992459 | Urea Cycle Disorders | Phase 3 | Completed | - | - |
| NCT00977600 | Healthy | Phase 1 | Completed | - | Ukraine ... more >> Medical Sanitary Division #2 Kharkiv, Ukraine, 61011 Collapse << |
| NCT00439569 | Spinal Muscular Atrophy Type I... more >>I Spinal Muscular Atrophy Type III Collapse << | Phase 1 Phase 2 | Terminated(Due to poor complia... more >>nce with study drug administration.) Collapse << | - | United States, California ... more >> Stanford University Medical Center, 300 Pasteur Drive, Room A343 Stanford, California, United States, 94305-5235 United States, Missouri Washington University Medical School, Washington University, 660 S. Euclid Avenue, Box 8111 St. Louis, Missouri, United States, 63110 United States, New York Columbia University, 180 Fort Washington Avenue, 5th Floor New York, New York, United States, 10032 United States, Pennsylvania The Children's Hospital of Philadelphia, Clinical Trials Office, A-230, 34th St. and Civic Center Boulevard Philadelphia, Pennsylvania, United States, 19104-4399 United States, Texas University of Texas Southwestern Medical Center at Dallas, Division of Pediatric Neurology, Children's Medical Center of Dallas, Ambulatory Care Pavilion, 2350 Stemmons Freeway, Suite #5074 Dallas, Texas, United States, 75207 Collapse << |
| NCT00001565 | Brain Neoplasms ... more >> Neuroblastoma Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 Collapse << |
| NCT00004871 | Leukemia Myel... more >>odysplastic Syndromes Myelodysplastic/Myeloproliferative Diseases Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231-2410 Collapse << |
| NCT00439569 | - | - | Terminated(Due to poor complia... more >>nce with study drug administration.) Collapse << | - | - |
| NCT00992459 | - | - | Completed | - | - |
| NCT00002909 | Lymphoma Unsp... more >>ecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> Johns Hopkins Oncology Center Baltimore, Maryland, United States, 21287 Collapse << |
| NCT01949766 | - | - | - | - | - |
| NCT00002796 | Mucinous Adenocarcinoma of the... more >> Colon Mucinous Adenocarcinoma of the Rectum Recurrent Colon Cancer Recurrent Rectal Cancer Signet Ring Adenocarcinoma of the Colon Signet Ring Adenocarcinoma of the Rectum Stage IVA Colon Cancer Stage IVA Rectal Cancer Stage IVB Colon Cancer Stage IVB Rectal Cancer Collapse << | Phase 1 Phase 2 | Terminated(Administratively co... more >>mplete.) Collapse << | - | United States, New York ... more >> Mount Sinai Medical Center New York, New York, United States, 10029 Collapse << |
| NCT00439218 | Spinal Muscular Atrophy Type I | Phase 1 Phase 2 | Terminated(Extremely slow enro... more >>llment) Collapse << | - | United States, California ... more >> Stanford University Medical Center, 300 Pasteur Drive, Room A343 Stanford, California, United States, 94305-5235 United States, Massachusetts Children's Hospital, Boston, 300 Longwood Avenue, Fegan 11 Boston, Massachusetts, United States, 02115 United States, New York Columbia University, 180 Fort Washington Avenue, 5th Floor New York, New York, United States, 10032 United States, Pennsylvania The Children's Hospital of Philadelphia, Clinical Trials Office, A-230, 34th St. and Civic Center Boulevard Philadelphia, Pennsylvania, United States, 19104-4399 United States, Texas University of Texas Southwestern Medical Center at Dallas, Division of Pediatric Neurology, Children's Medical Center of Dallas, Ambulatory Care Pavilion, 2350 Stemmons Freeway, Suite #5074 Dallas, Texas, United States, 75207 Collapse << |
| NCT03335488 | Urea Cycle Disorder | Phase 4 | Recruiting | March 31, 2020 | United States, New York ... more >> Mount Sinai School of Medicine Recruiting New York, New York, United States, 10029 Contact: Dr. George Diaz, M.D., PhD. 212-241-0858 George.Diaz@mssm.edu Contact: Luca Fierro 212 659 1477 luca.fierro@mssm.edu Principal Investigator: Dr. George Diaz, M.D., PhD. United States, Ohio University Hospitals Case Medical Center Recruiting Cleveland, Ohio, United States, 44106-6005 Contact: Dr. Jirair Bedoyan, MD 216-844-7124 Jirair.Bedoyan@UHhospitals.org Contact: Audrey Lynn 216 844 7124 audrey.lynn@UHhospitals.org United States, Pennsylvania Children's Hospital of Pittsburgh of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15224 Contact: Dr. Gerard Vockley, MD, PhD 412-692-7530 Jennifer.baker@chp.edu Contact: Jennifer Baker 412-692-7530 Jennifer.baker@chp.edu Principal Investigator: Dr. Gerard Vockley, MD, PhD United States, Utah University of Utah Recruiting Salt Lake City, Utah, United States, 84132 Contact: Dr. Nicola Longo, M.D., PhD. 801-587-3605 Nicola.Longo@hsc.utah.edu Contact: Carrie Bailey 801 587 3605 Carrie.Bailey@hsc.utah.edu Principal Investigator: Dr. Nicola Longo, M.D., PhD. Belgium Cliniques Universitaires Saint-Luc Recruiting Brussels, Belgium, 1200 Contact: Prof. Etienne Sokal, MD 32 2 764 13 87 etienne.sokal@uclouvain.be Contact: Julia Versavau 32 2 764 19 33 julia.versavau@uclouvain.be Principal Investigator: Prof. Etienne Sokal, MD Spain Hospital Materno-Infantil (HRU Carlos Haya) Recruiting Málaga, Andalucia, Spain, 29006 Contact: Dr. Javier Blasco-Alonso, MD 34 951 29 21 91 javierblascoalonso@yahoo.es Contact: Almudena Frias 34 951 29 21 91 Principal Investigator: Dr. Javier Blasco-Alonso Hospital Clinico Universitario de Santiago Recruiting Santiago de Compostela, Galicia, Spain, 15706 Contact: Dr. Maria Luz Couce-Pico, MD 34 981 950 162 maria.luz.couce.pico@sergas.es Contact: Maria Teresa Oreiro-Garcia 34 981 955 627 maria.teresa.oreiro.garcia@sergas.es Principal Investigator: Dr. Maria Luz Couce-Pico, MD Hospital Universitario de Cruces Recruiting Barakaldo, Vizcaya, Spain, 48903 Contact: Dr. Luis Jose Aldamiz-Echevar Azuara, MD 34 94 600 6327 LUISJOSE.ALDAMIZ-ECHEVARAZUARA@osakidetza.net Contact: Fernando Olatz 34 94 600 6327 fernando.andradelodeiro@osakidetza.eus Principal Investigator: Dr. Luis Jose Aldamiz-Echevar Azuara, MD Switzerland Universitätsspital, Inselspital Bern Recruiting Bern, Switzerland, 3010 Contact: Matthias Gautchshi,, MD 41 (0)31 632 01 47 Matthias.Gautschi@insel.ch Contact: Alexandra Nuoffer +41 (0)31 632 51 37 alexandra.nuoffer@insel.ch Principal Investigator: Dr. Matthias Gautchshi, MD University Children's Hospital Recruiting Zurich, Switzerland, 75, 8032 Contact: Prof Johannes Häberle, MD 41- 44-266-7111 johannes.haeberle@kispi.uzh.ch Contact: Ms. Doris Anzengruber 41- 44-266-7722 Doris.Anzengruber@kispi.uzh.ch Principal Investigator: Prof Johannes Häberle, MD Collapse << |
| NCT00528268 | Spinal Muscular Atrophy | Phase 1 Phase 2 | Completed | - | United States, Utah ... more >> University of Utah Salt Lake City, Utah, United States, 84132 Collapse << |
| NCT00439218 | - | - | Terminated(Extremely slow enro... more >>llment) Collapse << | - | - |
| NCT01784718 | - | - | - | - | - |
| NCT00528268 | - | - | Completed | - | - |
| NCT01702974 | HIV Infection | Phase 2 | Completed | - | Ethiopia ... more >> Black Lion Hospital (BLH), Addis Ababa University, Faculty of Medicine Addis Ababa, Lideta sub city, Ethiopia Collapse << |
| NCT00107770 | Amyotrophic Lateral Sclerosis | Phase 1 Phase 2 | Completed | - | United States, Iowa ... more >> VA Medical Center, Iowa City Iowa City, Iowa, United States, 52246-2208 United States, Kentucky VA Medical Center, Lexington Lexington, Kentucky, United States, 40502 United States, Maryland VA Maryland Health Care System, Baltimore Baltimore, Maryland, United States, 21201 United States, Massachusetts Edith Nourse Rogers Memorial Veterans Hospital, Bedford Bedford, Massachusetts, United States, 01730 VA Medical Center, Jamaica Plain Campus Boston, Massachusetts, United States, 02130 United States, New York VA Medical Center, Syracuse Syracuse, New York, United States, 13210 United States, North Carolina VA Medical Center, Durham Durham, North Carolina, United States, 27705 United States, Ohio VA Medical Center, Cincinnati Cincinnati, Ohio, United States, 45220 United States, Pennsylvania VA Pittsburgh Health Care System Pittsburgh, Pennsylvania, United States, 15240 United States, Texas Michael E. DeBakey VA Medical Center (152) Houston, Texas, United States, 77030 Collapse << |
| NCT00533559 | Diabetes Insu... more >>lin Resistance Collapse << | Phase 4 | Completed | - | Canada, Ontario ... more >> Toronto General Hospital Toronto, Ontario, Canada, M5G 2C4 Collapse << |
| NCT01698476 | Pulmonary Tuberculosis (TB) | Phase 2 | Completed | - | Ethiopia ... more >> Black Lion Hospital (BLH), Addis Ababa University, Faculty of Medicine Addis Ababa, Lideta sub city, Ethiopia Collapse << |
| NCT00947544 | Urea Cycle Disorders | Phase 2 | Completed | - | United States, California ... more >> UCLA Los Angeles, California, United States, 90095 United States, District of Columbia The George Washington DC Children's National Medical Center Washington, District of Columbia, United States, 20010 United States, New York Mount Sinai School of Medicine New York, New York, United States, 10029 United States, Pennsylvania University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15201 United States, Texas Baylor College of Medicine Houston, Texas, United States, 77030 United States, Washington Seattle Children's Hospital Seattle, Washington, United States, 98105 United States, Wisconsin Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226 Canada, Ontario The Hospital for Sick Children Toronto, Ontario, Canada, M5G1X8 Collapse << |
| NCT01580007 | Pulmonary Tuberculosis | Phase 2 | Completed | - | Bangladesh ... more >> National Institute of Diseases of Chest and Hospital (NIDCH) Dhaka, Bangladesh, 1212 Collapse << |
| NCT00947544 | - | - | Completed | - | - |
| NCT00345605 | Argininosuccinic Aciduria ... more >> Amino Acid Metabolism, Inborn Errors Urea Cycle Disorders Collapse << | Phase 2 | Completed | - | United States, Texas ... more >> Baylor College of Medicine Houston, Texas, United States, 77030 Collapse << |
| NCT00345605 | - | - | Completed | - | - |
| NCT00551200 | Urea Cycle Disorders | Phase 2 | Completed | - | United States, Minnesota ... more >> University of Minnesota Minneapolis, Minnesota, United States, 55455 United States, Texas Baylor College of Medicine Houston, Texas, United States, 77030 Collapse << |
| NCT03734263 | Pyruvate Dehydrogenase Complex... more >> Deficiency Collapse << | Phase 1 Phase 2 | Recruiting | October 1, 2019 | Italy ... more >> Federico II University Recruiting Napoli, Italy, 80131 Contact: Nicola Brunetti-Pierri +390817463288 brunetti@tigem.it Collapse << |
| NCT01096095 | Spinocerebellar Ataxia Type 3 | Phase 2 | Withdrawn(Regulatory authoriti... more >>es did not allow the entrance of the study drug in the country) Collapse << | July 2011 | Brazil ... more >> Hospital de Clínicas de Porto Alegre Porto Alegre, Rio Grande do Sul, Brazil, 90.035-903 Collapse << |
| NCT02111200 | Urea Cycle Disorders, Inborn | Not Applicable | Completed | - | United States, Texas ... more >> Children's Nutrition Research Center/Baylor College of Medicine Houston, Texas, United States, 77030 Collapse << |
| NCT01529060 | Maple Syrup Urine Disease | Phase 2 Phase 3 | Active, not recruiting | December 2017 | United States, Texas ... more >> Baylor College of Medicine Houston, Texas, United States, 77030 Collapse << |
| NCT02111200 | - | - | Completed | - | - |
| NCT00551200 | - | - | Completed | - | - |
| NCT00212316 | Huntington's Disease | Phase 2 | Completed | - | United States, Alabama ... more >> University of Alabama Birmingham, Alabama, United States United States, California University of California—San Diego San Diego, California, United States United States, Iowa University of Iowa Hospital and Clinics Iowa City, Iowa, United States United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States United States, Maryland Johns Hopkins University Baltimore, Maryland, United States United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States United States, New York Columbia University New York, New York, United States University of Rochester Rochester, New York, United States Collapse << |
| NCT02046434 | Parkinson's Disease | Phase 1 | Active, not recruiting | September 2018 | United States, Colorado ... more >> University of Colorado Denver Anschutz Medical Center Aurora, Colorado, United States, 80045 Collapse << |
| 靶点 | Description | IC50 |
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