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CAS No.: 532-32-1

苯甲酸钠 Catalog No. CSN24116

Synonyms: 安息香酸钠,苯甲酸钠盐

Sodium benzoate is a preservative and uesd as a food additive which is bacteriostatic and fungistatic under acidic conditions

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描述Sodium benzoate, a D-amino acid oxidase (DAAO) inhibitor, improved cognitive function of early-phase Alzheimer's disease (AD) after 24-week treatment^[1]. Sodium benzoate (SB) was well tolerated without evident side effects. Sodium benzoate adjuvant therapy improved symptomatology of patients with clozapine-resistant schizophrenia^[2]. SB significantly impaired memory and motor coordination. Moreover, SB decreased reduced GSH (reduced glutathione) and increased the MDA (malondialdehyde) level in the brain significantly. Short-term consumption of SB can impair memory performance and increased brain oxidative stress in mice^[3]. Repeated administration of sodium benzoate (400 and 800 mg/kg i.p.) and sulfasalazine (500 mg/kg orally) for 7 days, i.e. 2 days before and continued for 5 days after acetic acid infusion, significantly attenuated macroscopic damage and disease activity score as compared to disease control^[4].
参考文献

[1] Lin CH, Chen PK, Wang SH, Lane HY. Sodium benzoate for the treatment of behavioral and psychological symptoms of dementia (BPSD): A randomized, double-blind, placebo-controlled, 6-week trial. J Psychopharmacol. 2019;33(8):1030-1033
[2] Lin CH, Lin CH, Chang YC, et al. Sodium Benzoate, a D-Amino Acid Oxidase Inhibitor, Added to Clozapine for the Treatment of Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial. Biol Psychiatry. 2018;84(6):422-432
[3] Khoshnoud MJ, Siavashpour A, Bakhshizadeh M, Rashedinia M. Effects of sodium benzoate, a commonly used food preservative, on learning, memory, and oxidative stress in brain of mice. J Biochem Mol Toxicol. 2018;32(2):10.1002/jbt.22022
[4] Walia D, Kaur G, Jaggi AS, Bali A. Exploring the therapeutic potential of sodium benzoate in acetic acid-induced ulcerative colitis in rats. J Basic Clin Physiol Pharmacol. 2019;30(5):/j/jbcpp.2019.30.issue-5/jbcpp-2019-0086/jbcpp- 2019-0086.xml.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.9395 mL
- 34.6974 mL
- 69.3947 mL
- 5 mM
- 1.3879 mL
- 6.9395 mL
- 13.8789 mL
- 10 mM
- 0.6939 mL
- 3.4697 mL
- 6.9395 mL

技术信息

CAS号	532-32-1		储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C7H5NaO2		运输	蓝冰
分子量	144.10		别名	安息香酸钠,苯甲酸钠盐

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总药量计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 动物数量只每天给药次给药天

需要的总药量：mg

工作液计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 给药体积μL

您需要配制的工作液浓度为：mg/mL

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