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CAS No.: 156-54-7

丁酸钠 Catalog No. CSN11945

Synonyms: 丁酸钠

Sodium butyrate is a histone deacetylase (HDAC) inhibitor with IC50s are 0.3 mM, 0.4 mM, 0.3 mM for HDAC1, 2 and 7 respectively.

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技术信息

生物活性

描述Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. NaB (sodium butyrate) corrected the HFD(high-fat diet)-induced gut microbiota imbalance in mice^[3]. Sodium butyrate (NaB) increases α-Synuclein mRNA expression, enhances Atg5-mediated autophagy in murine neuroendocrine STC-1 cells. Moreover, the PI3K/Akt/mTOR pathway was significantly inhibited and cell apoptosis was activated by NaB. NaB-stimulated STC-1 cells induced inflammation in SH-SY5Y cells^[4]. NaB prevents excessive ROS through NOX2 (NADPH oxidase 2) suppression and SOD1 (superoxide dismutase 1) upregulation by p21/NRF2 pathway, which is critical for inhibiting BACE1-dependent amyloidogenesis in neuronal cells exposed to high cholesterol environment^[5]. In vivo, SB (Sodium Butyrate) significantly ameliorated the inflammatory response and intestinal epithelium barrier dysfunction in TNBS (2,4,6-trinitrobenzene sulfonic acid)-induced WT mice. In vitro, pre-treatment with SB dramatically inhibited the expression of TNF-α and IL-6 in LPS-induced RAW246.7 macrophages^[6].
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
human H1299 cells	-	Function assay	7 days	Inhibition of human USP1/UAF1 in human H1299 cells assessed as reduction in colony formation after 7 days, EC50=3 μM	25229643
human JEG3 cells	-	Function assay	-	Inhibition of aromatase in human JEG3 cells by scintillation spectrometry, IC50=0.0015 μM	20148564
human K562 cells	1 mM	Proliferation assay	-	Antiproliferative activity against human K562 cells at 1 mM in presence of guanosine	23937979

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01862380	Adrenal Hyperplasia, Congenita... more >>l 21-hydroxylase Deficiency Collapse <<	Not Applicable	Unknown	November 2016	France ... more >> Assistance Publique - Hôpitaux de Paris, Bicêtre Hospital Le Kremlin-bicetre, France, 94 275 Collapse <<
NCT03401398	Septic Shock	Phase 3	Not yet recruiting	April 30, 2023	-
NCT03110198	Ulcerative Colitis, Unspecifie... more >>d Collapse <<	Phase 4	Recruiting	March 2018	China, Shaanxi ... more >> Xijing Digestive Disease Recruiting Xi'an, Shaanxi, China, 710032 Contact: Jie liang, professor 86-029-84771535 liangjie@fmmu.edu.cn Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 9.0837 mL
- 45.4186 mL
- 90.8372 mL
- 5 mM
- 1.8167 mL
- 9.0837 mL
- 18.1674 mL
- 10 mM
- 0.9084 mL
- 4.5419 mL
- 9.0837 mL

技术信息

CAS号

156-54-7

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C4H7NaO2

运输

蓝冰

分子量

110.09

别名

丁酸钠

溶解度

DMSO	Insoluble
Ethanol	22.0 mg/mL (199.8 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01862380	Adrenal Hyperplasia, Congenita... more >>l 21-hydroxylase Deficiency Collapse <<	Not Applicable	Unknown	November 2016	France ... more >> Assistance Publique - Hôpitaux de Paris, Bicêtre Hospital Le Kremlin-bicetre, France, 94 275 Collapse <<
NCT03401398	Septic Shock	Phase 3	Not yet recruiting	April 30, 2023	-
NCT03110198	Ulcerative Colitis, Unspecifie... more >>d Collapse <<	Phase 4	Recruiting	March 2018	China, Shaanxi ... more >> Xijing Digestive Disease Recruiting Xi'an, Shaanxi, China, 710032 Contact: Jie liang, professor 86-029-84771535 liangjie@fmmu.edu.cn Collapse <<
NCT03766997	Granulomatous Mastitis	Phase 4	Not yet recruiting	January 2022	China, Beijing ... more >> Department of Breast Surgery,Peking Union Medical College Hospital Beijing, Beijing, China, 100730 Collapse <<
NCT01797562	Allergic Contact Dermatitis	Phase 4	Unknown	December 2015	United States, California ... more >> Rady Children's Hospital Recruiting San Diego, California, United States, 92123 Contact: Ann Funk, RN 858-576-1700 ext 4295 Principal Investigator: Lawrence Eichenfield, MD United States, Colorado Anschutz Health and Wellness Center, University of Colorado Recruiting Aurora, Colorado, United States, 80045 Contact: Teresa Derian, RN 303-724-9155 Principal Investigator: Cory Dunnick, MD United States, Kentucky Dermatology Specialists Recruiting Louisville, Kentucky, United States, 40202 Contact: Maureen Beyel, RN 502-582-7546 Principal Investigator: Joseph Fowler, MD United States, Oregon Oregon Health & Science University Recruiting Portland, Oregon, United States, 97239 Contact: Kristin Morton 503-494-6442 Principal Investigator: Patricia Norris, MD Collapse <<
NCT01518348	Contact Dermatitis	Phase 3	Withdrawn(Study has been updat... more >>ed with new protocol number) Collapse <<	December 2013	United States, Colorado ... more >> Anschutz Health and Wellness Center, University of Colorado Aurora, Colorado, United States, 80045 United States, Kentucky Dermatology Specialists Louisville, Kentucky, United States, 40202 Collapse <<
NCT00640614	Contact Dermatitis	Phase 3	Completed	-	United States, Arkansas ... more >> River City Dermatology Little Rock, Arkansas, United States, 72205 United States, Kansas American Dermatology Associates Shawnee, Kansas, United States, 66216 United States, Kentucky Dermatology Specialists PSC Louisville, Kentucky, United States, 40202-1864 United States, New York Winthrop University Hospital Mineola, New York, United States, 11501 Denmark Odense University Hospital Odense C, Denmark, DK-5000 Collapse <<
NCT02090504	Alcohol Withdrawal Syndrome ... more >> Alcohol Dependence Collapse <<	Phase 4	Completed	-	Austria ... more >> University of Wien Wien, AT, Austria Italy "G. Fontana" Centre for the Study and Multidisciplinary Treatment of Alcohol Addiction, Department of Clinical Medicine, University of Bologna Bologna, BO, Italy Catholic University of Rome Rome, Rm, Italy, 00168 Collapse <<
NCT00672308	Cholera	Phase 2	Completed	-	Bangladesh ... more >> ICDDR,B Dhaka, Bangladesh, 1212 Collapse <<
NCT01757379	Short Chain Fatty Acids Bioava... more >>ilability Collapse <<	Not Applicable	Completed	-	Belgium ... more >> KU Leuven/ UZ Leuven Leuven, Vlaams-Brabant, Belgium, 3000 Collapse <<
NCT01983046	Obesity Type ... more >>2 Diabetes Collapse <<	Not Applicable	Completed	-	Netherlands ... more >> University Maastricht Maastricht, Limburg, Netherlands, 6229 ER Collapse <<
NCT00843167	Breast Cancer ... more >> Precancerous Condition Collapse <<	Phase 2	Completed	-	United States, Oregon ... more >> Knight Cancer Institute at Oregon Health and Science University Portland, Oregon, United States, 97239-3098 Collapse <<
NCT00843167	-	-	Completed	-	-
NCT00693355	Healthy	Not Applicable	Completed	-	Netherlands ... more >> University of Maastricht Maastricht, Limburg, Netherlands, 6202MD Collapse <<
NCT00640614	-	-	Completed	-	-
NCT00800930	Shigellosis	Phase 2	Completed	-	Bangladesh ... more >> Dhaka Hospital & Matlab Hospital Dhaka, Bangladesh, 1212 ICDDR,B Dhaka, Bangladesh, 1212 Collapse <<
NCT03010865	Schizophrenic Disorder ... more >> Cognitive Impairment Collapse <<	Phase 2 Phase 3	Not yet recruiting	February 2020	China, Shanghai ... more >> Shanghai Mental Health Center Not yet recruiting Shanghai, Shanghai, China, 200030 Contact: Chunbo Li, M.D. 86-21-34773243 chunbo_li@163.com Principal Investigator: Chunbo Li, M.D. Collapse <<
NCT02654405	Schizophrenic Disorders ... more >> Cognitive Function Collapse <<	Phase 2 Phase 3	Withdrawn(Nathan Kline Institu... more >>te (NKI) decided not to accept study grant from Stanley Medical Research Foundation. because of budget considerations.) Collapse <<	May 2016	United States, New York ... more >> Nathan Kline Insitute for Psychiatric Research Orangeburg,, New York, United States, 10962 Collapse <<
NCT00696098	Gut Health	Not Applicable	Completed	-	Netherlands ... more >> University of Maastricht Maastricht, Limburg, Netherlands, 6202 MD Collapse <<
NCT02271802	SCFA Metabolism	Not Applicable	Completed	-	Netherlands ... more >> Maastricht University Maastricht, Netherlands, 6229ER Collapse <<

丁酸钠 Catalog No. CSN11945

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