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CAS No.: 126-17-0

Solasodine/茄胺 Catalog No. CSN11960

Synonyms: Purapuridine;Solancarpidine;Solasodin

Solasodine is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family.

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技术信息

生物活性

描述Solasodine is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities. Solasodine induces strong expression of the different neuronal markers studied, including βIII-tubulin, synaptophysin, MAP2, ChAT, and neuroblast marker doublecortin. Solasodine (375 μM; i.c.v.; for 2 weeks) treatment results a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining^[3]. Intraperitoneal (i.p.) injection of solasodine (25 mg/kg) significantly delayed latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. In the MES model, solasodine significantly reduced duration of HLTE at 25, 50, and 100 mg/kg, i.p. in a dose-dependent manner. Treatment of solasodine (25, 50, and 100 mg/kg, i.p.) significantly potentiated thiopental-provoked sleep in a dose-dependent manner^[4]. CD133, CD44, Nanog, Oct-4 and Sox-2 were inhibited by solasodine to reverse stemness and similar mechanism was stimulated in vivo. Moreover, solasodine attenuated TGF-β1-induced EMT and decreased MMPs while in vivo study showed the same trend^[5]. Inhibition of A549 cell invasion by solasodine may be, at least in part, through blocking MMP expression. Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4176 mL
- 12.0879 mL
- 24.1759 mL
- 5 mM
- 0.4835 mL
- 2.4176 mL
- 4.8352 mL
- 10 mM
- 0.2418 mL
- 1.2088 mL
- 2.4176 mL

技术信息

CAS号

126-17-0

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H43NO2

运输

蓝冰

分子量

413.64

别名

Purapuridine;Solancarpidine;Solasodin;NSC 179187;NSC 178260;Solasod-5-en-3β-ol;Salasdine;澳洲茄胺

溶解度

DMSO	insoluble
Water	insoluble

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