|(3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-(4-(4-(3-氨基苯基)-1H-1,2,3-三唑-1-基)丁基)-10-(((2S,3R,4S,6R)-4-(二甲基氨基)-3-羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-4-乙基-7-氟-11-甲氧基--3a,7,9,11,13,15-六甲基八氢-1H-[1]氧杂环十四烷并[4,3-d]恶唑-2,6,8,14(7H,9H)-四酮|CsnPharm

CAS No.: 760981-83-7

Solithromycin/索利霉素 Catalog No. CSN16880

Synonyms: CEM-101;OP-1068;索利霉素

Solithromycin is a fluoroketolide with improved antimicrobial effectiveness.

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技术信息

生物活性

描述Solithromycin is a fluoroketolide with improved antimicrobial effectiveness.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01168713	Community-Acquired Bacterial P... more >>neumonia Collapse <<	Phase 2	Completed	-	-
NCT02268279	Bacterial Infection	Phase 1	Completed	-	-
NCT01966055	Bacterial Infections	Phase 1	Completed	-	United States, Arkansas ... more >> Little Rock, Arkansas, United States, 72202 United States, California San Diego, California, United States, 92123 United States, Illinois Chicago, Illinois, United States, 60611 United States, Kentucky Louisville, Kentucky, United States, 40202 United States, Michigan Ann Arbor, Michigan, United States, 48109 United States, New Jersey Hackensack, New Jersey, United States, 07601 United States, New York New York, New York, United States, 10032 United States, Oregon Portland, Oregon, United States, 97239 United States, Pennsylvania Hershey, Pennsylvania, United States, 17033 United States, Texas Galveston, Texas, United States, 77555-0701 Houston, Texas, United States, 77030 Collapse <<

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参考文献

[1] Mancuso AM, Gandhi MA, et al. Solithromycin (CEM-101): A New Fluoroketolide Antibiotic and Its Role in the Treatment of Gonorrhea. J Pharm Pract. 2017 Jan 1.
[2] Rodgers W, Frazier AD, et al. Solithromycin inhibition of protein synthesis and ribosome biogenesis in Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae. Antimicrob Agents Chemother. 2013 Apr;57(4):1632-7.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.1834 mL
- 5.9171 mL
- 11.8342 mL
- 5 mM
- 0.2367 mL
- 1.1834 mL
- 2.3668 mL
- 10 mM
- 0.1183 mL
- 0.5917 mL
- 1.1834 mL

技术信息

CAS号

760981-83-7

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C43H65FN6O10

运输

蓝冰

分子量

845.01

别名

CEM-101;OP-1068;索利霉素

溶解度

DMSO	98.0 mg/mL (116.0 mM)
Water	Insoluble
Ethanol	25.0 mg/mL (29.6 mM)

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01168713	Community-Acquired Bacterial P... more >>neumonia Collapse <<	Phase 2	Completed	-	-
NCT02268279	Bacterial Infection	Phase 1	Completed	-	-
NCT01966055	Bacterial Infections	Phase 1	Completed	-	United States, Arkansas ... more >> Little Rock, Arkansas, United States, 72202 United States, California San Diego, California, United States, 92123 United States, Illinois Chicago, Illinois, United States, 60611 United States, Kentucky Louisville, Kentucky, United States, 40202 United States, Michigan Ann Arbor, Michigan, United States, 48109 United States, New Jersey Hackensack, New Jersey, United States, 07601 United States, New York New York, New York, United States, 10032 United States, Oregon Portland, Oregon, United States, 97239 United States, Pennsylvania Hershey, Pennsylvania, United States, 17033 United States, Texas Galveston, Texas, United States, 77555-0701 Houston, Texas, United States, 77030 Collapse <<
NCT01756339	Community-acquired Bacterial P... more >>neumonia Collapse <<	Phase 3	Completed	-	-
NCT01591447	Uncomplicated Urogenital Gonor... more >>rhea Collapse <<	Phase 2	Completed	-	United States, Alabama ... more >> Jefferson County Department of Health Birmingham, Alabama, United States, 35233 United States, Washington Harborview STD Clinic Seattle, Washington, United States, 98104 Collapse <<
NCT01968733	Community-acquired Bacterial P... more >>neumonia Collapse <<	Phase 3	Completed	-	-
NCT02210325	Uncomplicated Urogenital Gonor... more >>rhea Collapse <<	Phase 3	Completed	-	United States, Maryland ... more >> Baltimore, Maryland, United States, 21205 United States, Ohio Cleveland, Ohio, United States, 44109 Toledo, Ohio, United States, 43614 Australia, New South Wales Sydney, New South Wales, Australia, 2000 Australia, Victoria Melbourne, Victoria, Australia, 3053 Collapse <<
NCT02510599	Nonalcoholic Steatohepatitis	Phase 2	Completed	-	United States, Ohio ... more >> Case Western University Hospitals Cleveland, Ohio, United States, 44106 Collapse <<
NCT02605122	Community-acquired Bacterial P... more >>neumonia Collapse <<	Phase 2 Phase 3	Terminated(Development not pro... more >>ceeding) Collapse <<	-	-
NCT02348424	Gonorrhoea	Phase 1	Completed	-	United States, Maryland ... more >> Johns Hopkins Bayview Medical Center - Infectious Diseases Baltimore, Maryland, United States, 21224-2735 Collapse <<
NCT02628769	Pulmonary Disease, Chronic Obs... more >>tructive Collapse <<	Phase 2	Terminated	-	United Kingdom ... more >> Muscle Lab, Respiratory Medicine, Harefield Hospital Harefield, Middlesex, United Kingdom, UB9 6JH Collapse <<

Solithromycin/索利霉素 Catalog No. CSN16880

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