|9-(四氢呋喃-2-基)-9H-嘌呤-6-胺|CsnPharm

CAS No.: 17318-31-9

SQ22536/9-(四氢-2-呋喃)腺膘呤 Catalog No. CSN11972

Synonyms: 9-(tetrahydrofuran-2-yl)-9h-purin-6-amine;SQ-22,536;SQ 22,536. NSC 53339

SQ22536 is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述SQ 22536 is an adenylyl cyclase inhibitor with IC50 value of 1μM for blocking the increase in cyclic AMP level in human blood platelets. It inhibited the reversal of platelet aggregation. It significantly inhibited responses to NECA-induced relaxation of the rat isolated thoracic aorta at 100μM. Inhibition of adenylyl cyclase by SQ 22536 at 10μM for 48h blocked NGF-stimulated cAMP production in PC12 cells.
作用机制SQ 22536 is a 9-substituted adenine derivative.^[1]
动物研究
剂量
Mice: 2 mg/kg^[4] (s.c.), 10 mg/kg^[5] (s.c.)

给药途径
s.c.
参考文献

动物研究
剂量	Mice: 2 mg/kg^[4] (s.c.), 10 mg/kg^[5] (s.c.)
给药途径	s.c.

[1] Harris DN, Asaad MM, et al. Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives. J Cyclic Nucleotide Res. 1979;5(2):125-34.
[2] Hourani SM, Boon K, et al. Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues. Br J Pharmacol. 2001 Jul;133(6):833-40.
[3] Chen MC, Lin H, et al. Involvement of cAMP in nerve growth factor-triggered p35/Cdk5 activation and differentiation in PC12 cells. Am J Physiol Cell Physiol. 2010 Aug;299(2):C516-27.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.8729 mL
- 24.3645 mL
- 48.7290 mL
- 5 mM
- 0.9746 mL
- 4.8729 mL
- 9.7458 mL
- 10 mM
- 0.4873 mL
- 2.4365 mL
- 4.8729 mL

技术信息

CAS号

17318-31-9

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H11N5O

运输

蓝冰

分子量

205.22

别名

9-(tetrahydrofuran-2-yl)-9h-purin-6-amine;SQ-22,536;SQ 22,536. NSC 53339;NSC-53339

溶解度

DMSO	100.0 mg/mL (487.3 mM)
Water	100.0 mg/mL (487.3 mM)

动物实验配方

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SQ22536/9-(四氢-2-呋喃)腺膘呤 Catalog No. CSN11972

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