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CAS No.: 174689-39-5

SR59230A Catalog No. CSN25553

SR59230A is a potent and selective Adrenergic Receptor β3 antagonist with IC50 values of 40, 408, and 648nM for Adrenergic Receptor β3, β1 and β2, respectively. It shows blood-brain barrier penetrability.

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400-920-2911

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生物活性

实验方案

技术信息

生物活性

描述Β₃-adrenoceptor is the last identified member of adrenergic receptors, involved in different tumor conditions, such as melanoma^[1]. SR59230A is a potent and selective β₃-adrenoceptor antagonist with IC₅₀ values of 40, 408, and 648 nM for β₃-, β₁-, and β₂-receptors, respectively^[2]. In the NB (neuroblastoma) cell lines, treatment with SR59230A for 24 h was able to reduce cell viability in a dose-dependent manner^[1]. In 24-h fasted Wistar rats, both doses (10, 50 nmol) of SR59230A reduced the risk assessment (RA) frequency (number/30 min) (4 ± 2 for saline-treated vs 1 ± 1 for 10 nmol and 0.5 ± 1 for 50 nmol SR59230A-treated rats), an ethological parameter related to anxiety. Further, pretreatment with SR59230A (7.0 ± 0.5 g) abolished the hypophagia induced by BRL37344 (3.6 ± 0.9 g, agonist of β₃-adrenoceptor)^[2].
参考文献

[1] Bruno G, Cencetti F, Pini A, et al. β₃-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P₂ modulation. Oncogene. 2020;39(2):368-384
[2] Kanzler SA, Januario AC, Paschoalini MA. Involvement of β3-adrenergic receptors in the control of food intake in rats. Braz J Med Biol Res. 2011;44(11):1141-1147

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4069 mL
- 12.0343 mL
- 24.0686 mL
- 5 mM
- 0.4814 mL
- 2.4069 mL
- 4.8137 mL
- 10 mM
- 0.2407 mL
- 1.2034 mL
- 2.4069 mL

技术信息

CAS号

174689-39-5

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H29NO6

运输

蓝冰

分子量

415.48

别名

溶解度

DMSO	82.0 mg/mL (197.4 mM)
Water	Insoluble
Ethanol	10.0 mg/mL (24.1 mM)

动物实验配方

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