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CAS No.: 1793052-96-6

SRS16-86 Catalog No. CSN32740

SRS16-86, a ferrostatin analog, is a novel third-generation inhibitor of ferroptosis. It is the first compound in this class that is stable in plasma and liver microsomes and that demonstrates high efficacy when supplied alone or in combination therapy.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Ferroptosis is a newly discovered type of cell death triggered by intracellular phospholipid peroxidation that is morphologically, biologically and genetically distinct from other types of cell death. Ferroptosis is classified as regulated necrosis and is more immunogenic than apoptosis^[1]. SRS16-86 is a novel third-generation ferrostatin, is an inhibitor of ferroptosis. SRS16-86 is more stable to metabolism and plasma than Ferrostatin-1 in vivo. SRS16-86 can be used for renal ischemia-reperfusion injury (IRI) and spinal cord injury (SCI) research^[2]. In a rat model of spinal cord injury, SRS16-86 (15 mg/kg) increases the levels of glutathione peroxidase 4 (GPX4), system xc- cystine/glutamate transporter (xCT), and glutathione (GSH) and decreases levels of IL-1β, TNF-α, ICAM-1, and the lipid peroxidation marker 4-hydroxy nonenal (4HNE) in injured spinal cord epicenters. It also increases tissue sparing and improves locomotor recovery in the same model^[3].
参考文献

[1] Yitian Sun,et al. The emerging role of ferroptosis in inflammation. Biomed Pharmacother. 2020. 127, 110108.
[2] Linkermann, A., Skouta, R. et al. Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci U S A. 2014. 111(47), 16836-41.
[3] Zhang, Y., Sun, C., Zhao, C., et al. Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury. Brain Res. 2019. 1706, 48-57.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3118 mL
- 11.5591 mL
- 23.1183 mL
- 5 mM
- 0.4624 mL
- 2.3118 mL
- 4.6237 mL
- 10 mM
- 0.2312 mL
- 1.1559 mL
- 2.3118 mL

技术信息

CAS号	1793052-96-6	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C26H32N4O2	运输	蓝冰
分子量	432.56	别名

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