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CAS No.: 4136-37-2

Stachydrine HCl/盐酸水苏碱 Catalog No. CSN11976

Synonyms: 盐酸水苏碱

Stachydrine HCl is a naturally occuring anti-metastatic agent in vitro which is isolated from seed husk and the pulp of the fruit of C. Leonurus.

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技术信息

生物活性

描述Stachydrine hydrochloride, a well-known bioactive ingredients extracted from Herba Leonuri. Stachydrine can inhibit the NF-κB signal pathway with anti-hypertrophic activities. In vitro, IC₅₀ of Stachydrine hydrochloride for MCF-7 and T47D is about 500 µM. High concentrations (500 µM and 1000 µM) of Stachydrine significantly increased the frequency of both studied cell lines at the G1 phase of cell cycle^[3]. In vivo, Stachydrine hydrochloride can significantly reduce the death rate of mice, improve the pathological changes in the hippocampus, inhibit inflammatory reactions after ischemia^[4].
参考文献

[1] Wang M, Shu ZJ, et al. Stachydrine hydrochloride inhibits proliferation and induces apoptosis of breast cancer cells via inhibition of Akt and ERK pathways. Am J Transl Res. 2017 Apr 15;9(4):1834-1844.
[2] Li X, Wang B, et al. The Th1/Th2/Th17/Treg paradigm induced by stachydrine hydrochloride reduces uterine bleeding in RU486-induced abortion mice. J Ethnopharmacol. 2013 Jan 9;145(1):241-53.
[3] Wang M, Shu ZJ, Wang Y, Peng W. Stachydrine hydrochloride inhibits proliferation and induces apoptosis of breast cancer cells via inhibition of Akt and ERK pathways. Am J Transl Res. 2017 Apr 15;9(4):1834-1844. PMID: 28469788; PMCID: PMC5411931.
[4] Miao M, Wang T, Lou X, MingBai, Xi P, Liu B, Chang B. The influence of stachydrine hydrochloride on the reperfusion model of mice with repetitive cerebral ischemia. Saudi J Biol Sci. 2017 Mar;24(3):658-663. doi: 10.1016/j.sjbs.2017.01.039. Epub 2017 Jan 23. PMID: 28386193; PMCID: PMC5372397.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.5665 mL
- 27.8327 mL
- 55.6655 mL
- 5 mM
- 1.1133 mL
- 5.5665 mL
- 11.1331 mL
- 10 mM
- 0.5567 mL
- 2.7833 mL
- 5.5665 mL

技术信息

CAS号

4136-37-2

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C7H14ClNO2

运输

蓝冰

分子量

179.64

别名

盐酸水苏碱

溶解度

DMSO	146.0 mg/mL (812.7 mM)

动物实验配方

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Stachydrine HCl/盐酸水苏碱 Catalog No. CSN11976

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