|(1R,2S,13bS,14aS)-2-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1-乙烯基-1,2,7,8,13,13b,14,14a-八氢-5H-吲哚并[2,3-a]吡喃并[3,4-g]喹嗪-5-酮|CsnPharm

CAS No.: 23141-25-5

Strictosamide Catalog No. CSN14159

Strictosamide, a natural product isolated and purified from the herbs of Nauclea latifolia, may have important effects on inflammation and inflammatory pain, shows slightly toxicity to Charles River mouse (LD(50)=723.17 mg/kg), producing CNS depression and kidney toxicity, and has nonsignificant in vitro and in vivo effect on kidney Na(+),K(+)-ATPase activity but produced an in vivo increase of Na(+),K(+)-ATPase activity of brain.

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生物活性

描述Strictosamide, a natural product isolated and purified from the herbs of Nauclea latifolia, may have important effects on inflammation and inflammatory pain, shows slightly toxicity to Charles River mouse (LD(50)=723.17 mg/kg), producing CNS depression and kidney toxicity, and has nonsignificant in vitro and in vivo effect on kidney Na(+),K(+)-ATPase activity but produced an in vivo increase of Na(+),K(+)-ATPase activity of brain.
参考文献

[1] Li Z, Li Z, et al. Synthesis and Biological Evaluation of Strictosamide Derivatives with Improved Antiviral and Antiproliferative Activities. Chem Biol Drug Des. 2015 Oct;86(4):523-30.
[2] Li N, Cao L, et al. In vivo anti-inflammatory and analgesic activities of strictosamide from Nauclea officinalis. Pharm Biol. 2014 Nov;52(11):1445-50.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0059 mL
- 10.0296 mL
- 20.0592 mL
- 5 mM
- 0.4012 mL
- 2.0059 mL
- 4.0118 mL
- 10 mM
- 0.2006 mL
- 1.0030 mL
- 2.0059 mL

技术信息

CAS号	23141-25-5	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C26H30N2O8	运输	蓝冰
分子量	498.53	别名

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