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CAS No.: 116-43-8

Succinylsulfathiazole/琥珀酰磺胺噻唑 Catalog No. CSN11995

Synonyms: Succinylsulphathiazole;NSC 14193;Succinilsolfatiazolo

Succinylsulfathiazole is a competitive inhibitor of DHFR, as it is a sulfonamide.

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技术信息

生物活性

描述Succinylsulfathiazole is a sulfonamide and an ultra long acting drug. Adding succinylsulfathiazole lowered total folate excretion from 13.8 +/- 8.2 to 4.8 +/- 2.9 nmol/d in agreement with its role in inhibiting bacterial folate synthesis.In addition, succinylsulfathiazole lowered liver folate in rats fed control and test diets approximately equally with a mean decrease from 11.6 +/- 2.5 to 7.5 +/- 2.5 nmol/g wet liver, suggesting that the antibiotic also affected rat folate absorption and/or metabolism^[1]. Both male and female offspring exposed peri-conceptionally to SST (succinylsulphathiazole) showed reduced social interactions, reduced exploration of the open arm by 20% in the elevated plus maze test indicating increased anxiety and altered sensorimotor gating, with a 1.5-2-fold decrease in startle inhibition^[2]. Low 5-MTHF without SST significantly increased the number of immature neurones compared to low and high 5-MTHF (5-methyltetrahydrofolate) + SST, indicating that SST interfered with elevations in neurogenesis^[3].
参考文献

[1] Sepehr E, Peace RW, Storey KB, Jee P, Lampi BJ, Brooks SP. Folate derived from cecal bacterial fermentation does not increase liver folate stores in 28-d folate-depleted male Sprague-Dawley rats. J Nutr. 2003;133(5):1347–1354
[2] Degroote S, Hunting DJ, Baccarelli AA, Takser L. Maternal gut and fetal brain connection: Increased anxiety and reduced social interactions in Wistar rat offspring following peri-conceptional antibiotic exposure. Prog Neuropsychopharmacol Biol Psychiatry. 2016;71:76–82
[3] Qiu W, Gobinath AR, Wen Y, Austin J, Galea LAM. Folic acid, but not folate, regulates different stages of neurogenesis in the ventral hippocampus of adult female rats. J Neuroendocrinol. 2019;31(10):e12787

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8138 mL
- 14.0691 mL
- 28.1381 mL
- 5 mM
- 0.5628 mL
- 2.8138 mL
- 5.6276 mL
- 10 mM
- 0.2814 mL
- 1.4069 mL
- 2.8138 mL

技术信息

CAS号

116-43-8

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H13N3O5S2

运输

蓝冰

分子量

355.39

别名

Succinylsulphathiazole;NSC 14193;Succinilsolfatiazolo;Sulfadigesin;Colistatin;Kaoxidine;Sulfasuxidine;琥珀酰磺胺噻唑

溶解度

DMSO	50.0 mg/mL (140.7 mM)
Water	insoluble

动物实验配方

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Succinylsulfathiazole/琥珀酰磺胺噻唑 Catalog No. CSN11995

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