|1,2-二苯基-4-[2-(苯基亚磺酰基)乙基]吡唑烷-3,5-二酮|CsnPharm

CAS No.: 57-96-5

Sulfinpyrazone/(±)-磺吡酮 Catalog No. CSN16856

Synonyms: G-28315;NSC 75925;Anturane

(±)-Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.

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技术信息

生物活性

描述(±)-Sulfinpyrazone is an orally active and potent uricosuric agent for chronic and intermittent gouty arthritis. Sulfinpyrazone has antithrombotic and platelet inhibitory effects. The normal total dose of sulfinpyrazone as an antithrombotic agent is 800 mg daily. The drug has been used continuously for up to 4 years with no serious adverse reactions or laboratory abnormalities. Sulfinpyrazone is not a substitute for conventional anticoagulant agents (e.g. the coumarin derivatives) in the treatment of venous thrombosis, but is an important drug for the treatment of conditions associated with arterial thrombosis and possibly for the prophylaxis of recurrent venous thrombosis^[3]. In rats with kaolin-induced paw oedema this compound is able to restore the markedly prolonged euglobulin clot lysis time in an oral dose of 30 mg/kg, whereas salicylate and dipyridamole are somewhat less active in this respect. Beside these effects, sulfinpyrazone protects rabbits from arachidonate-induced sudden death after a single oral dose of 10 - 30 mg/kg^[4].
参考文献

[1] Raeder EA, Verrier RL, Lown B. Effects of sulfinpyrazone on ventricular vulnerability in the normal and the ischemic heart. Am J Cardiol. 1982 Aug;50(2):271-5.
[2] Rosenberg JC, Sell TL. In vitro evaluation of inhibitors of platelet release and aggregation. Arch Surg. 1975 Aug;110(8):980-3.
[3] Margulies EH, White AM, Sherry S. Sulfinpyrazone: a review of its pharmacological properties and therapeutic use. Drugs. 1980;20(3):179-197
[4] Rüegg M. Antithrombotic effects of sulfinpyrazone in animals: influence on fibrinolysis and sodium arachidonate-induced pulmonary embolism. Pharmacology. 1976;14(6):522-536

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4723 mL
- 12.3615 mL
- 24.7230 mL
- 5 mM
- 0.4945 mL
- 2.4723 mL
- 4.9446 mL
- 10 mM
- 0.2472 mL
- 1.2362 mL
- 2.4723 mL

技术信息

CAS号

57-96-5

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H20N2O3S

运输

蓝冰

分子量

404.48

别名

G-28315;NSC 75925;Anturane;Anturanil;(±)-磺吡酮

溶解度

DMSO	79.0 mg/mL (195.3 mM)
Water	Insoluble
Ethanol	63.0 mg/mL (155.8 mM)

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