|4-((4-(2-((4-氨基-2,3,5,6-四甲基苯基)氨基)-N-甲基乙酰胺)哌啶-1-基)甲基)苯甲酰胺|CsnPharm

CAS No.: 704869-38-5

SUN11602 Catalog No. CSN22070

Synonyms: SUN11602

SUN11602 is a mimic of basic fibroblast growth factor (bFGF) which can prevent glutamate-induced neuronal death and increase the levels of CALB1 gene expression in cerebrocortical neurons.

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400-920-2911

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技术信息

生物活性

描述Physiological actions of SUN11602 mimic several phenomena of the neuroprotection that is induced by bFGF. SUN11602 plays a pivotal role in allowing primary cultured neurons to survive in adverse environments of glutamate toxicity and activating intracellular key molecules that are involved in the neuroprotective mechanisms. These actions are quite similar to those of bFGF. Such neuroprotective mechanisms are specific and distinctive to SUN11602 and bFGF and differs clearly from those of the other growth factors that are investigated. But unlike bFGF, SUN11602 can either directly or indirectly trigger the phosphorylation of the cytosolic domain of the FGFR without binding to the extracellular domain of the FGFR-1. SUN11602 demonstrates no cell proliferative activity of somatic cells, unlike bFGF. SUN11602 significantly affects neuronal survival in adverse conditions through a FGFR1-mitogen-activated protein kinase/extracellular signal-regulated kinase-1/2 kinase (FGFR-1–MEK/ERK) signaling pathway.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2143 mL
- 11.0716 mL
- 22.1433 mL
- 5 mM
- 0.4429 mL
- 2.2143 mL
- 4.4287 mL
- 10 mM
- 0.2214 mL
- 1.1072 mL
- 2.2143 mL

技术信息

CAS号

704869-38-5

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H37N5O2

运输

蓝冰

分子量

451.60

别名

SUN11602

溶解度

DMSO	165.0 mg/mL (365.4 mM)
Water	insoluble

动物实验配方

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