生物活性

• 描述Tafamidis is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03431896	-	-	Recruiting	February 15, 2024	United States, Ohio ... more >> Cleveland Clinic Recruiting Cleveland, Ohio, United States, 44195 Collapse <<
  NCT03190577	Familial Amyloid Neuropathy ... more >> Transthyretin Amyloidosis Collapse <<	Not Applicable	Recruiting	January 30, 2021	France ... more >> Chu Angers Not yet recruiting Angers, France, 49000 Contact: julien Chassereau, MD          Sub-Investigator: Vivien PAUTOT, MD          Chru Brest Not yet recruiting Brest, France, 29609 Contact: STEEVE GENESTET, MD          Chd La Roche Sur Yon Active, not recruiting La Roche-sur-Yon, France, 85000 Ch La Rochelle Recruiting La Rochelle, France, 17019 Contact: KARINE BOYER, MD          Ch Le Mans Active, not recruiting Le Mans, France, 72033 Chu Nantes Recruiting Nantes, France Contact: ARMELLE MAGOT          Chu Poitiers Active, not recruiting Poitiers, France, 86021 Ch Quimper Recruiting Quimper, France, 29107 Contact: Maud LEPETIT, MD          Chu Rennes Active, not recruiting Rennes, France, 35033 Ch Saint Brieuc Recruiting Saint-Brieuc, France, 22000 Contact: BENOIT PEGAT, MD          Ch Saint Nazaire Recruiting Saint-Nazaire, France, 44606 Contact: Lucie METZGER, MD          Chru Tours Active, not recruiting Tours, France, 37044 Collapse <<
  NCT03591757	Transthyretin Amyloidosis ... more >> Amyloidosis, Leptomeningeal, Transthyretin-Related Collapse <<	Early Phase 1	Recruiting	March 2019	United States, Massachusetts ... more >> Amyloidosis Center, Boston Medical Center Recruiting Boston, Massachusetts, United States, 02118 Contact: John L Berk, MD    617-638-4494    jberk@bu.edu Collapse <<

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• 参考文献

• [1] Marcoux J, Mangione PP, et al. A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis. EMBO Mol Med. 2015 Oct;7(10):1337-49.

  [2] Bulawa CE, Connelly S, et al. Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9629-34.