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CAS No.: 426219-18-3

Tak-700 Catalog No. CSN12728

Synonyms: Orteronel;Orteronel racemic mixture

TAK-700 is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits > 1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4).

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400-920-2911

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述TAK-700 is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits > 1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4).
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01193244	Prostate Cancer	Phase 3	Completed	-	-
NCT01193257	Prostate Cancer	Phase 3	Completed	-	-
NCT02054793	Prostate Cancer ... more >> Castration-resistant Prostate Cancer Collapse <<	Phase 1 Phase 2	Withdrawn(This study was never... more >> able to open due to lack of funding from the pharmaceutical company.) Collapse <<	July 2016	United States, District of Col... more >>umbia Sibley Memorial Hospital Washington, District of Columbia, United States, 20016 United States, Maryland Johns Hopkins University Baltimore, Maryland, United States, 21231 United States, Michigan Karmanos Cancer Institute Detroit, Michigan, United States Collapse <<

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参考文献

[1] Yamaoka M, Hara T, et al. Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys. J Steroid Biochem Mol Biol. 2012 Apr;129(3-5):115-28.
[2] Kaku T, Hitaka T, et al. Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer. Bioorg Med Chem. 2011 Nov 1;19(21):6383-99.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2537 mL
- 16.2683 mL
- 32.5366 mL
- 5 mM
- 0.6507 mL
- 3.2537 mL
- 6.5073 mL
- 10 mM
- 0.3254 mL
- 1.6268 mL
- 3.2537 mL

技术信息

CAS号	426219-18-3	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C18H17N3O2	运输	蓝冰
分子量	307.35	别名	Orteronel;Orteronel racemic mixture

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01193244	Prostate Cancer	Phase 3	Completed	-	-
NCT01193257	Prostate Cancer	Phase 3	Completed	-	-
NCT02054793	Prostate Cancer ... more >> Castration-resistant Prostate Cancer Collapse <<	Phase 1 Phase 2	Withdrawn(This study was never... more >> able to open due to lack of funding from the pharmaceutical company.) Collapse <<	July 2016	United States, District of Col... more >>umbia Sibley Memorial Hospital Washington, District of Columbia, United States, 20016 United States, Maryland Johns Hopkins University Baltimore, Maryland, United States, 21231 United States, Michigan Karmanos Cancer Institute Detroit, Michigan, United States Collapse <<
NCT01546987	Prostate Cancer	Phase 3	Active, not recruiting	June 2024	-
NCT01666314	Prostate Cancer	Phase 1 Phase 2	Completed	-	United States, Nebraska ... more >> Urology Cancer Center, PC Omaha, Nebraska, United States, 68130 Collapse <<
NCT01707966	Prostate Cancer	Phase 3	Completed	-	Switzerland ... more >> Kantonspital Aarau Aarau, Switzerland, CH-5001 Universitaetsspital Basel Basel, Switzerland, 4031 Istituto Oncologico della Svizzera Italiana - Ospedale Regionale Bellinzona e Valli Bellinzona, Switzerland, 6500 Inselspital Bern Bern, Switzerland, CH-3010 Kantonsspital Graubuenden Chur, Switzerland, 7000 Kantonsspital Freiburg Freiburg, Switzerland, 1708 Hôpitaux Universitaires de Genève HUG Geneva 14, Switzerland, 1211 Centre Hospitalier Universitaire Vaudois CHUV Lausanne, Switzerland, CH-1011 Kantonsspital Luzern Luzern, Switzerland, 6000 Kantonsspital Muensterlingen Muensterlingen, Switzerland, 8596 Spital Männedorf Männedorf, Switzerland, 8708 Kantonsspital St. Gallen St. Gallen, Switzerland, 9007 SpitalSTS AG Simmental-Thun-Saanenland Thun, Switzerland, 3600 Kantonsspital Winterthur Winterthur, Switzerland, 8401 UniversitaetsSpital Zuerich Zurich, Switzerland, 8091 Collapse <<
NCT01193244	-	-	Completed	-	-
NCT01666314	-	-	Completed	-	-
NCT02101684	Metastatic or Advanced Non-res... more >>ectable Granulosa Cell Ovarian Tumors Collapse <<	Phase 2	Terminated(Slow recruitment ra... more >>te) Collapse <<	-	Spain ... more >> Hospital Son Llatzer Palma de Mallorca, Islas Baleares, Spain, 07198 Complexo Hospitalario Universitario de Santiago Santiago de Compostela, La Coruña, Spain, 15706 Hospital Universitario Fundación Alcorcón Alcorcón, Madrid, Spain, 28922 Complejo Hospitalario de Navarra Pamplona, Navarra, Spain, 31008 Hospital Del Mar Barcelona, Spain, 08003 Complejo Hospitalario Regional Reina Sofía Córdoba, Spain, 14004 Hospital Universitario La Paz Madrid, Spain, 28046 Hospital Universitario Madrid Sanchinarro Madrid, Spain, 28050 Hospital Universitari I Politècnic La Fe Valencia, Spain, 46026 Collapse <<
NCT01866423	Adenocarcinoma of the Prostate... more >> Hormone-resistant Prostate Cancer Recurrent Prostate Cancer Stage IV Prostate Cancer Collapse <<	Phase 2	Terminated(Not progressing tow... more >>ard scientific goals) Collapse <<	-	United States, California ... more >> USC Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 Collapse <<
NCT02053311	Prostate Cancer	Phase 3	Withdrawn(Due to former trials... more >>, drug has not demonstrated a clinical profile sufficient to move forward in mCRPC) Collapse <<	August 19, 2034	Switzerland ... more >> Kantonsspital Baden Baden, Switzerland, CH-5404 Istituto Oncologico della Svizzera Italiana - Ospedale Regionale Bellinzona e Valli Bellinzona, Switzerland, 6500 Kantonsspital Graubuenden Chur, Switzerland, CH-7000 Kantonsspital Luzern Luzerne, Switzerland, CH-6000 Kantonsspital Muensterlingen Münsterlingen, Switzerland, 8596 Kantonsspital - St. Gallen St. Gallen, Switzerland, CH-9007 SpitalSTS AG Simmental-Thun-Saanenland Thun, Switzerland, 3600 Collapse <<
NCT01990209	Metastatic Breast Cancer	Phase 2	Recruiting	February 1, 2020	United States, Connecticut ... more >> Yale School of Medicine Recruiting New Haven, Connecticut, United States, 06520 United States, Florida Florida Hospital Cancer Institute Recruiting Orlando, Florida, United States, 32804 Woodlands Medical Specialists Withdrawn Pensacola, Florida, United States, 32503 Space Coast Cancer Center Withdrawn Titusville, Florida, United States, 32796 United States, Georgia Northeast Georgia Medical Center Recruiting Gainesville, Georgia, United States, 30501 United States, Indiana Hope Cancer Center Recruiting Terre Haute, Indiana, United States, 47802 United States, Kentucky Baptist Hospital East Recruiting Louisville, Kentucky, United States, 40207 United States, Maryland Center for Cancer and Blood Disorders Recruiting Bethesda, Maryland, United States, 20817 United States, Michigan Cancer Research Consortium of West Michigan Recruiting Grand Rapids, Michigan, United States, 49503 United States, Oklahoma Cancer Centers of SW Oklahoma Recruiting Lawton, Oklahoma, United States, 73505 United States, Tennessee Tennessee Oncology PLLC Recruiting Chattanooga, Tennessee, United States, 37404 Tennessee Oncology PLLC Recruiting Nashville, Tennessee, United States, 37203 United States, Texas Center for Cancer and Blood Disorders Recruiting Fort Worth, Texas, United States, 76104 Collapse <<
NCT01866423	-	-	Terminated(Not progressing tow... more >>ard scientific goals) Collapse <<	-	-
NCT01549951	Prostate Cancer	Phase 2	Completed	-	United States, Arizona ... more >> Pinnacle Oncology Scottsdale, Arizona, United States, 85258 Collapse <<
NCT01084655	Prostate Cancer	Phase 1 Phase 2	Completed	-	United States, Alaska ... more >> Alaska Clinical Research Center, LLC Anchorage, Alaska, United States, 99508 Collapse <<
NCT01658527	Prostate Cancer	Phase 2	Withdrawn(Pharmaceutical compa... more >>ny has terminated orteronel (TAK-700) development for Prostate Cancer) Collapse <<	January 2017	Belgium ... more >> Onze Lieve Vrouw Ziekenhuis Aals, Belgium Cliniques Universitaires Saint-Luc Brussels, Belgium AZ Groeninge Kortrijk - Campus Vercruysselaan Kortrijck, Belgium CHU Dinant Godinne - UCL Namur Yvoir, Belgium Collapse <<
NCT01549951	-	-	Completed	-	-
NCT01046916	Prostate Cancer	Phase 2	Completed	-	United States, Michigan ... more >> University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 United States, Oregon Oregon Health and Sciences University Portland, Oregon, United States, 97239 United States, Wisconsin University of Wisconsin Hospitals and Clinics Madison, Wisconsin, United States, 53705 Collapse <<
NCT01816048	Prostatic Neoplasms ... more >> Prostate Cancer Collapse <<	Phase 2	Terminated(Study supporter (Ta... more >>keda) ended study drug for prostate cancer; enrollment ended prematurely.) Collapse <<	-	United States, Wisconsin ... more >> University of Wisconsin Carbone Cancer Center Madison, Wisconsin, United States, 53792 Collapse <<
NCT01809691	Prostate Cancer	Phase 3	Active, not recruiting	October 2027	-
NCT03211052	Prostate Cancer	Phase 2	Terminated(IMP no longer avail... more >>able) Collapse <<	-	United Kingdom ... more >> St Bartholomew's Hospital London, United Kingdom Collapse <<
NCT01816048	-	-	Terminated(Study supporter (Ta... more >>keda) ended study drug for prostate cancer; enrollment ended prematurely.) Collapse <<	-	-
NCT00569153	Prostatic Neoplasms	Phase 1 Phase 2	Completed	-	United States, California ... more >> USC Westside Prostate Cancer Center Beverly Hills, California, United States University of Southern California Los Angeles, California, United States, 90048 The Angeles Clinic and Research Institute Los Angeles, California, United States USC Norris Comprehensive Cancer Center Los Angeles, California, United States United States, Florida South Florida Medical Research Aventura, Florida, United States Florida Cancer Specialists Fort Myers, Florida, United States United States, Illinois Northwestern University Medical Center Chicago, Illinois, United States, 60611 University of Chicago Chicago, Illinois, United States, 60637 University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States University of Chicago Pharmacy Chicago, Illinois, United States Evanston Hospital Evanston, Illinois, United States Kellogg Pharmacy - Evanston Hospital Evanston, Illinois, United States NorthShore University HealthSystem Evanston, Illinois, United States Kellogg Cancer Care Center Glenview, Illinois, United States United States, New York Hematology/Oncology Associates of Central New York East Syracuse, New York, United States United States, Ohio Gabrail Cancer Center Canton, Ohio, United States Cleveland Clinic Cleveland, Ohio, United States, 44195 Taussig Cancer Institute Cleveland, Ohio, United States United States, Tennessee Tennessee Oncology Nashville, Tennessee, United States Collapse <<
NCT01808040	Post Menopausal, Hormone Recep... more >>tor Positive Breast Cancer Collapse <<	Phase 1	Completed	-	United States, Wisconsin ... more >> University of Wisconsin Madison, Wisconsin, United States, 53792 Collapse <<

Tak-700 Catalog No. CSN12728

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