CAS No.: 1374598-80-7
TAK-875半水合物 Catalog No. CSN15825
TAK-875 is a selective GPR40 agonist with EC50 of 14 nM in human GPR40 expressing CHO cell line, 400-fold more potent than oleic acid.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 细胞研究
- Cell Data
- 参考文献
- [1] Kaku K, Enya K, et al. Efficacy and safety of fasiglifam (TAK-875), a G protein-coupled receptor 40 agonist, in Japanese patients with type 2 diabetes inadequately controlled by diet and exercise: a randomized, double-blind, placebo-controlled, phase III trial. Diabetes Obes Metab. 2015 Jul;17(7):675-81.
- [2] Tsujihata Y, Ito R, et al. TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats. J Pharmacol Exp Ther. 2011 Oct;339(1):228-37.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1374598-80-7 | 储存条件 |
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| 分子式 | C58H66O15S2 | 运输 | 蓝冰 | |
| 分子量 | 1067.27 | 别名 |
