|Tat-NR2B9c游离态|CsnPharm

CAS No.: 500992-11-0

Tat-NR2B9c Catalog No. CSN19139

Synonyms: Tat-NR2Bct;NA-1

Tat-NR2B9c is a PSD95 inhibitor with EC50 of 7 nM, also inhibit p38.

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400-920-2911

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实验方案

技术信息

生物活性

描述Postsynaptic density protein-95 (PSD-95)/Discs-large/ZO-1 (PDZ) domains play an essential role in the regulation of intracellular signaling involved in neuronal disease and cancer. Tat-NR2B9c is a 20-mer peptide consisting of nine C-terminal amino acids of the NMDA NR2B subunit. It inhibits PSD-95 domain 1 and PSD-95 domain 2 with EC50 values of 670 nM and 6.7 nM, respectively. The IC50 values for Tat-NR2B9c inhibiting the interactions between NMDAR2A, NMDAR2B, NMDAR2C and PSD-95 are 0.5, 8, and 0.75μm, respectively. Tat-NR2B9c also inhibits the interaction between neuronal nitric oxide synthase and PSD-95 with an IC50 value of 0.2μm^[3]. In NMDA-treated neuronal cultures, Tat-NR2B9c at 0.5µM suppressed NMDA-induced superoxide production by 75%. The NMDA-type glutamate receptor-triggered NOX2 activation and DNA damage were also prevented by Tat-NR2B9c at 0.5µM^[4]. In mice subjected to temporary middle cerebral artery occlusion (tMCAO) for 30 and 60 min, treatment with 10nmol/g Tat-NR2B9c significantly decreased infarct volumes by 24.5% and 26.0%, respectively^[5].
动物研究
剂量
Rat: 1.12 mg/kg^[3] (i.v.)

给药途径
i.v.
临床研究
NCT号适应症或疾病临床期招募状态预计完成时间地点
NCT02930018 Stroke, Acute Phase 3 Recruiting April 2020 -
参考文献

动物研究
剂量	Rat: 1.12 mg/kg^[3] (i.v.)
给药途径	i.v.

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02930018	Stroke, Acute	Phase 3	Recruiting	April 2020	-

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.3970 mL
- 1.9850 mL
- 3.9700 mL
- 5 mM
- 0.0794 mL
- 0.3970 mL
- 0.7940 mL
- 10 mM
- 0.0397 mL
- 0.1985 mL
- 0.3970 mL

技术信息

CAS号

500992-11-0

储存条件

粉末: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C105H188N42O30

运输

蓝冰

分子量

2518.88

别名

Tat-NR2Bct;NA-1

溶解度

DMSO	180.0 mg/mL (71.5 mM)
Water	80.0 mg/mL (31.8 mM)

动物实验配方

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