|(4R,5S,6S)-(新戊酰氧基)甲基 3-((1-(4,5-二氢噻唑-2-基)氮杂环丁基-3-基)硫基)-6-((R)-1-羟乙基)-4-甲基-7-氧代-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸酯|CsnPharm

CAS No.: 161715-24-8

Tebipenem pivoxil/泰比培南酯 Catalog No. CSN12676

Synonyms: L084;ME-1211;Tebipenem Pivoxil

Tebipenem Pivoxil is a pivaloyloxymethyl ester prodrug of tebipenem with improved bioavailability, which works as a broad-spectrum antibiotic.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述It is well known that carbapenem antibiotics have broad-spectrum activities and strong bactericidal actions against members of the family Enterobacteriaceae, Pseudomonas aeruginosa, and gram-positive cocci except methicillin-resistant Staphylococcus aureus and metallo-β-lactamase-producing pathogens. Tebipenem pivoxil (TBPM-PI) is a new oral carbapenem antibiotic. TBPM-PI was very active against the S. pneumoniae isolates, with MICs of 0.002 to 0.031 μg/ml for the gPISP isolates and 0.016 to 0.125 μg/ml for the gPRSP isolates. The MICs of TBPM-PI ranged from ≤0.001 to 0.004 μg/ml for all PSSP and gPISP (2x) isolates. S. pneumoniae isolates ME19 (serotype 19F) cell wall synthesis stopped in the pneumococcal cells exposed to TBPM-PI at 0.063 μg/ml (the MIC) and 0.125 μg/ml (two times the MIC) for 2 h, and the protrusions were pulled in the direction of the long axis with the swelling of the cell^[3]. In mouse, rat, dog and monkey, TBPM-PI were absorbed quickly, and the bioavailability was 71.4, 59.1, 34.8 and 44.9%, respectively. After single oral administration of 10 mg/kg ¹⁴C-TBPM-PI to rat, 36.9-42.7% and 58.3-62.2% of radioactivity was excreted to urine and feces, respectively, by 120 hours after administration^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03395249	Healthy Volunteers	Phase 1	Completed	-	Australia, New South Wales ... more >> Scientia Clinical Research Ltd Randwick, New South Wales, Australia, 2031 Collapse <<

参考文献

[1] Kato K, Shirasaka Y, et al. Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport. Mol Pharm. 2010 Oct 4;7(5):1747-56.
[2] Kijima K, Morita J, et al. [Pharmacokinetics of tebipenem pivoxil, a novel oral carbapenem antibiotic, in experimental animals] . Jpn J Antibiot. 2009 Jun;62(3):214-40. Japanese.
[3] Kobayashi R, Konomi M, Hasegawa K, Morozumi M, Sunakawa K, Ubukata K. In vitro activity of tebipenem, a new oral carbapenem antibiotic, against penicillin-nonsusceptible Streptococcus pneumoniae. Antimicrob Agents Chemother. 2005;49(3):889‐894
[4] Kijima K, Morita J, Suzuki K, et al. Jpn J Antibiot. 2009;62(3):214‐240

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0095 mL
- 10.0477 mL
- 20.0953 mL
- 5 mM
- 0.4019 mL
- 2.0095 mL
- 4.0191 mL
- 10 mM
- 0.2010 mL
- 1.0048 mL
- 2.0095 mL

技术信息

CAS号

161715-24-8

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H31N3O6S2

运输

蓝冰

分子量

497.63

别名

L084;ME-1211;Tebipenem Pivoxil;TBPM-PI;SPR-994;TBM-PI;泰比培南酯

溶解度

DMSO	99.0 mg/mL (198.9 mM)
Water	Insoluble
Ethanol	85.0 mg/mL (170.8 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Tebipenem pivoxil/泰比培南酯 Catalog No. CSN12676

靶点选择性

请登录您的专属账户

确认信息