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CAS No.: 869572-92-9

Tecovirimat Catalog No. CSN18507

Synonyms: Arestvyr;SIGA-246;ST-246

Tecovirimat is a potent, selective and orally bioavailable antipoxvirus compound active against multiple orthopoxviruses, including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), and variola viruses, with EC50 value of 0.01μM for Vaccinia virus in CPE assays.

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技术信息

生物活性

描述Tecovirimat is a potent, selective and orally bioavailable antipoxvirus compound active against multiple orthopoxviruses, including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), and variola viruses, with EC50 value of 0.01μM for Vaccinia virus in CPE assays. It inhibited plaque formation, virus-induced CPE and extracellular virus production at 5μM. Treatment with oral administration of Tecovirimat, at dose of 50 mg/kg twice a day for 14 days, protected BALB/c mice from lethal infection by vaccinia virus strain IHD-J, A/NCr mice from lethal infection by ectromelia virus^[4]. Tecovirimat is FDA-approved for the treatment of human smallpox disease caused by Variola virus in adults and children^[5].
作用机制Tecovirimat blocks interaction of p37 with Rab9 and TIP47. Thus, ST-246 prevents wrapping complex formation by inhibiting interaction of p37 with components of LE-transport vesicle biogenesis^[3].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00728689	Orthopoxviral Disease ... more >> Smallpox Monkey Pox Collapse <<	Phase 1	Completed	-	United States, Florida ... more >> Orlando Clinical Research Center Orlando, Florida, United States, 32809 Collapse <<
NCT00728689	-	-	Completed	-	-
NCT00907803	-	-	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6572 mL
- 13.2862 mL
- 26.5725 mL
- 5 mM
- 0.5314 mL
- 2.6572 mL
- 5.3145 mL
- 10 mM
- 0.2657 mL
- 1.3286 mL
- 2.6572 mL

技术信息

CAS号	869572-92-9	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C19H15F3N2O3	运输	蓝冰
分子量	376.33	别名	Arestvyr;SIGA-246;ST-246;TPOXX

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00728689	Orthopoxviral Disease ... more >> Smallpox Monkey Pox Collapse <<	Phase 1	Completed	-	United States, Florida ... more >> Orlando Clinical Research Center Orlando, Florida, United States, 32809 Collapse <<
NCT00728689	-	-	Completed	-	-
NCT00907803	-	-	Completed	-	-
NCT00431951	Healthy	Phase 1	Completed	-	United States, Florida ... more >> Orlando Clinical Research Orlando, Florida, United States, 32809 Collapse <<
NCT02080767	-	-	-	-	-
NCT00431951	-	-	Completed	-	-
NCT00907803	Orthopoxviral Disease	Phase 2	Completed	-	United States, California ... more >> Apex Research Institute Santa Ana, California, United States, 92705 United States, Florida Orlando Clinical Research Center Orlando, Florida, United States, 32809 United States, Hawaii Hawaii Clinical Research Center Honolulu, Hawaii, United States, 96813 Collapse <<
NCT02474589	Smallpox	Phase 3	Completed	-	United States, Alabama ... more >> Coastal Clinical Research, Inc. Mobile, Alabama, United States, 36608 United States, California Paradigm Research Redding, California, United States, 96001 Paradigm Research San Diego, California, United States, 92117 United States, Kansas Johnson County Clinical Trials Lenexa, Kansas, United States, 66219 Heartland Research Associates, LLC Newton, Kansas, United States, 67114 United States, Missouri Center for Pharmaceutical Research Kansas City, Missouri, United States, 64114 Sundance Clinical Research LLC Saint Louis, Missouri, United States, 63141 United States, Nebraska Meridien Clinical Research Omaha, Nebraska, United States, 68134 United States, South Carolina Medical Research South Charleston, South Carolina, United States, 29407 United States, Texas Benchmark Research Austin, Texas, United States, 78705 Benchmark Research Fort Worth, Texas, United States, 76135 Collapse <<
NCT02474589	-	-	Completed	-	-

Tecovirimat Catalog No. CSN18507

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