CAS No.: 1221186-53-3
TEPP-46 Catalog No. CSN13660
Synonyms: ML-265;CID-44246499;NCGC-00186528
TEPP-46 is a potent and selective activator of recombinant pyruvate kinase M2 (PKM2) with half-maximum activating concentration (AC50 value) of 92 nM, and has little or no effect on PKM1, PKL and PKR.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Palsson-McDermott EM, Curtis AM, et al. Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015 Jan 6;21(1):65-80.
- [2] Anastasiou D, Yu Y, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol. 2012 Oct;8(10):839-47. Erratum in: Nat Chem Biol. 2012 Dec;8(12):1008.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1221186-53-3 | 储存条件 |
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| 分子式 | C17H16N4O2S2 | 运输 | 蓝冰 | |
| 分子量 | 372.46 | 别名 | ML-265;CID-44246499;NCGC-00186528 |
