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CAS No.: 6809-52-5

Teprenone/替普瑞酮 Catalog No. CSN12051

Synonyms: Geranylgeranylacetone;替普瑞酮;替普瑞农

Teprenone is used as an anti-ulcer drug, a cardioprotective agent, a hepatoprotective agent, a nephroprotective agent, a neuroprotective agent and a Hsp70 inducer.

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实验方案

技术信息

生物活性

描述Teprenone is commonly utilized to protect the gastric mucosa in peptic ulcer disease and has been shown to protect the myocardium from ischemia/reperfusion by inducing expression of heat shock proteins.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01397448	Gastric or Duodenal Ulcers Cau... more >>sed by Low-dose Aspirin Collapse <<	Phase 2 Phase 3	Completed	-	-
NCT01397448	-	-	Completed	-	-
NCT01284647	Chronic Erosive Gastritis	Phase 4	Completed	-	China, Beijing ... more >> Tongren Hospital Beijing, Beijing, China China, Guangdong Zhongshan Hospital of Xiamen University Xiamen, Guangdong, China China, Guangxi First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi, China China, Liaoning First Affiliated Hospital of Dalian Medical University Dalian, Liaoning, China China, Shanghai Changhai Hospital Shanghai, Shanghai, China Shanghai Xinhua Hospital Shanghai, Shanghai, China China, Shanxi First Affiliated Hospital of Shanxi Medical University Taiyuan, Shanxi, China China, Tianjin General Hospital of Tianjin Medical University Tianjin, Tianjin, China Collapse <<

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参考文献

[1] He D, Song X, et al. Geranylgeranylacetone protects against cerebral ischemia and reperfusion injury: HSP90 and eNOS phosphorylation involved. Brain Res. 2015 Mar 2;1599:150-7.
[2] Katsuno M, Sang C, et al. Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease. Proc Natl Acad Sci U S A. 2005;102(46):16801-6

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0253 mL
- 15.1263 mL
- 30.2526 mL
- 5 mM
- 0.6051 mL
- 3.0253 mL
- 6.0505 mL
- 10 mM
- 0.3025 mL
- 1.5126 mL
- 3.0253 mL

技术信息

CAS号

6809-52-5

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H38O

运输

蓝冰

分子量

330.55

别名

Geranylgeranylacetone;替普瑞酮;替普瑞农

溶解度

DMSO	66.0 mg/mL (199.7 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01397448	Gastric or Duodenal Ulcers Cau... more >>sed by Low-dose Aspirin Collapse <<	Phase 2 Phase 3	Completed	-	-
NCT01397448	-	-	Completed	-	-
NCT01284647	Chronic Erosive Gastritis	Phase 4	Completed	-	China, Beijing ... more >> Tongren Hospital Beijing, Beijing, China China, Guangdong Zhongshan Hospital of Xiamen University Xiamen, Guangdong, China China, Guangxi First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi, China China, Liaoning First Affiliated Hospital of Dalian Medical University Dalian, Liaoning, China China, Shanghai Changhai Hospital Shanghai, Shanghai, China Shanghai Xinhua Hospital Shanghai, Shanghai, China China, Shanxi First Affiliated Hospital of Shanxi Medical University Taiyuan, Shanxi, China China, Tianjin General Hospital of Tianjin Medical University Tianjin, Tianjin, China Collapse <<
NCT01547559	Non-steroidal Anti-inflammator... more >>y Drug Adverse Reaction Collapse <<	Not Applicable	Unknown	-	China, Guangdong ... more >> the first Affiliated Hospital of Sun Yat-Sen university Guang zhou, Guangdong, China, 510008 the first Affiliated Hospital of Sun Yat-Sen university Guang zhou, Guangdong, China, 510080 Collapse <<
NCT01190657	Acute Gastritis ... more >> Gastric Ulcer Collapse <<	Phase 4	Completed	-	China ... more >> Chinese People's Liberation Army General Hospital of Beijing Military Beijing, China Chongqing First People's Hospital Chongqing, China The Second Affiliated Hospital of Chongqing Medical University Chongqing, China Wuhan Union Hospital Hubei, China Changsha Central Hospital Hunan, China Hunan Provincial People's Hospital Hunan, China Nanjing First Hospital Jiangsu, China Nanjing General Hospital of Nanjing Military Command Jiangsu, China The Second Affiliated Hospital of Nanjing Medical University Jiangsu, China The Second Affiliated Hospital of Suzhou University Jiangsu, China Wuxi #2 People's Hospital Jiangsu, China Jilin University First Hospital Jilin, China Shengjing Hospital of China Medical University Liaoning, China Shanghai Changzheng Hospital Shanghai, China Shanghai First People's Hospital Shanghai, China Shanghai Renji Hospital Shanghai, China Shanghai Ruijin Hospital Shanghai, China Shanghai Sixth People's Hospital Shanghai, China Shanghai Tenth People's Hospital Shanghai, China Shanxi Provincial People's Hospital Shanxi, China The Second Affiliated Hospital of the Medical College of Xi'an Jiaotong University Shanxi, China Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Sichuan, China The Affiliated Hospital of Luzhou Medical College Sichuan, China Tongji Hospital Sichuan, China Hangzhou Red Cross Hospital Zhejiang, China The First Affiliated Hospital of Zhejiang University Zhejiang, China Collapse <<

Teprenone/替普瑞酮 Catalog No. CSN12051

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