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CAS No.: 78628-80-5

Terbinafine HCl/盐酸特比萘芬 Catalog No. CSN12053

Synonyms: TDT 067 hydrochloride;KWD 2019;Terbinafine (hydrochloride)

Terbinafine HCl is a naphthalene-derived allylamine antifungal, working by inhibiting squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes.

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描述Terbinafine hydrochloride (TBH), belonging to the allylamine class, is mainly used for treatment of onychomycosis^[3]. Terbinafine (Hydrochioride) is a new powerful antifungal agent indicated for both oral and topical treatment of mycosessince. It is highly effective in the treatment of determatomycoses^[4]. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida with Ki of 30 nM. In contrast, inhibition of rat liver squalene epoxidase only occurs at higher drug concentrations (Ki = 77 mM), and is competitive with squalene^[5]. Meta-analysis of published studies of toenail onychomycosis showed that a continuous terbinafine regimen is generally significantly superior to a pulsed terbinafine regimen for mycological cure^[6]. Fractional CO2 laser treatment combined with terbinafine cream for 6 months was an effective and safe method for the treatment of onychomycosis^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0498 mL
- 15.2490 mL
- 30.4980 mL
- 5 mM
- 0.6100 mL
- 3.0498 mL
- 6.0996 mL
- 10 mM
- 0.3050 mL
- 1.5249 mL
- 3.0498 mL

技术信息

CAS号

78628-80-5

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H26ClN

运输

蓝冰

分子量

327.89

别名

TDT 067 hydrochloride;KWD 2019;Terbinafine (hydrochloride);BRN-4256376;Terbinafine;Lamisil;Terbinafine HCl;盐酸特比萘芬

溶解度

DMSO	65.0 mg/mL (198.2 mM)
Water	Insoluble
Ethanol	65.0 mg/mL (198.2 mM)

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