|2,3,5,6-四甲基吡嗪|CsnPharm

CAS No.: 1124-11-4

Tetramethylpyrazine/川芎嗪 Catalog No. CSN15720

Synonyms: Chuanxiongzine;Tetramethylpyrazine;2,3,5,6-Tetramethylpyrazine

Tetramethylpyrazine, a natural product isolated and purified from the rhizome of Ligusticum chuanxiong Hort., can protect against CoCl2 -induced neurotoxicity and apoptosis in PC12 cells and in rats.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Tetramethylpyrazine, found in Chinese black vinegar, has many biological activities. In vitro studies, tetramethylpyrazine could modulate the level of intracellular cholesterol in HepG2 cells^[1]. Besides this, it was found that tetramethylpyrazine could protect primary rat cortical neurons against oxygen-glucose deprivation-induced death, through attenuating the down-regulating of member 6 (TRPC6) ^[2]. In vivo studies, tetramethylpyrazine, combined with resveratrol and curcumin, has the ability of significantly improving the paw swelling in acute paw swelling mouse model by inhibiting the expression of some special cytokine, while has low toxicity^[3]. In addition, tetramethylpyrazine could contribute to the amelioration of cisplatin-induced ototoxicity in rats^[4] .
参考文献

[1] Chen J, Tian J, et al. Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells. Food Chem Toxicol. 2017;109(Pt 2):930-940.
[2] Shao Z, Wang L, et al. Tetramethylpyrazine Protects Neurons from Oxygen-Glucose Deprivation-Induced Death. Med Sci Monit. 2017.
[3] Chen L, Liu T, et al. Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo. BMC Complement Altern Med. 2017;17(1):233.
[4] Bayram A, Kaya A, et al. The protective role of tetramethylpyrazine against cisplatin-induced ototoxicity. Int J Pediatr Otorhinolaryngol. 2017.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 7.3427 mL
- 36.7134 mL
- 73.4268 mL
- 5 mM
- 1.4685 mL
- 7.3427 mL
- 14.6854 mL
- 10 mM
- 0.7343 mL
- 3.6713 mL
- 7.3427 mL

技术信息

CAS号

1124-11-4

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C8H12N2

运输

蓝冰

分子量

136.19

别名

Chuanxiongzine;Tetramethylpyrazine;2,3,5,6-Tetramethylpyrazine;Chuanxingzine;NSC 36080;NSC 46451;TMP;川芎嗪;四甲基吡嗪

溶解度

DMSO	27.0 mg/mL (198.2 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Tetramethylpyrazine/川芎嗪 Catalog No. CSN15720

靶点选择性

请登录您的专属账户

确认信息