CAS No.: 719277-26-6
TG003 Catalog No. CSN16121
TG003 is a potent inhibitor of Clk1/Sty and Clk4 with IC50 of 15-20 nM, less potency on Clk2 (IC50= 200 nM).
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- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00596258 Cervical Intraepithelial Neopl... more >>asia Uterine Cervical Dysplasia Collapse << Phase 2 Completed - United States, Arizona ... more >> Visions Clinical Research-Tucson Tucson, Arizona, United States, 85712 United States, California Robin Black OGNP Costa Mesa, California, United States, 92629 United States, Florida Visions Clinical Research Boynton Beach, Florida, United States, 33437 United States, New York Montefiore Medical Center-Weiler Division Dept of OB/GYN & Women's Health Bronx, New York, United States, 10461 NYU School of Medicine New York, New York, United States, 10016 Collapse << NCT02075138 - - Completed - United States, District of Col... more >>umbia Washington, District of Columbia, United States United States, Illinois Normal, Illinois, United States United States, Ohio Sylvania, Ohio, United States United States, Oregon Medford, Oregon, United States United States, Washington Spokane, Washington, United States Argentina Buenos Aires City, Buenos Aires, Argentina Chile Temuco, Araucanía, Chile Collapse << - 参考文献
- [1] Brown GT, McIntyre TM. Lipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1β-rich microparticles. J Immunol. 2011 May 1;186(9):5489-96.
- [2] Muraki M, Ohkawara B, et al. Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem. 2004 Jun 4;279(23):24246-54
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技术信息
| CAS号 | 719277-26-6 | 储存条件 |
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| 分子式 | C13H15NO2S | 运输 | 蓝冰 | |
| 分子量 | 249.33 | 别名 |
