|N-[(7R,8S)-2-羧基-7,8-二氢-8-羟基-4-[(1S)-1-羟乙基]-7-喹啉基]-L-异亮烷基-L-丙氨酰基-2,3-二氢苯丙氨酰基-L-丙氨酰基-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-氨基-21-[(1S,2R)-1,2-二羟基-1-甲基丙基]-14-亚乙基-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-十六氢-11,28-双[(1R)-1-羟乙基] -9,12,19,26-四氧代-17H,26H-8,5:18,15:25,22:32,29-四腈-5H,15H-吡啶基[3,2-m][1,11,17,24,4,7,20,27]四硫杂四氮杂三环己二胺-2-基]-4-噻唑羰基-2,3-二氢丙氨酸-2,3-二氢-丙氨酸酰胺, (1→528) 内酯|CsnPharm

CAS No.: 1393-48-2

Thiostrepton/硫链丝菌素 Catalog No. CSN12080

Synonyms: Alaninamide;Bryamycin;Thiactin

Thiostrepton is a natural cyclic oligopeptide antibiotic, is a natural product of the ribosomally synthesized and post-translationally modified peptide (RiPP) class.

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技术信息

生物活性

描述Thiostrepton is a natural antibiotic produced by bacteria of Streptomyces genus. Thiostrepton (and MG-132 proteasome inhibitor) trigger upregulation of heat shock proteins HspA1A, Hsp70, Hsp90α, or Hsp105 in various human cancer cells^[2]. Thiostrepton significantly inhibited the growth of M. abscessus wild-type strains, subspecies, clinical isolates, and drug-resistant mutants in vitro and in macrophages. In addition, treatment of macrophages with thiostrepton significantly decreased proinflammatory cytokine production in a dose-dependent manner, suggesting an inhibitory effect of thiostrepton on inflammation induced during M. abscessus infection^[3]. In non-small-cell lung cancer (NSCLC) cells, thiostrepton inhibited CSC (Cancer stem cells) growth in vitro and reduced protein expression of cancer stemness markers, including CD133, Nanog and Oct4A. In addition, metastasis-associated Src tyrosine kinase signalling, cell migration and epithelial-to-mesenchymal transition (EMT) were all inhibited by thiostrepton. Thiostrepton combined with gemcitabine synergistically suppressed NSCLC cell growth and induced apoptosis^[4]. TS (thiostrepton) inhibited the growth of a panel of 96 multidrug-resistant (MDR) P. aeruginosa clinical isolates at low-micromolar concentrations. TS also had activity against Acinetobacter baumannii clinical isolates^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.6006 mL
- 3.0032 mL
- 6.0064 mL
- 5 mM
- 0.1201 mL
- 0.6006 mL
- 1.2013 mL
- 10 mM
- 0.0601 mL
- 0.3003 mL
- 0.6006 mL

技术信息

CAS号

1393-48-2

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C72H85N19O18S5

运输

蓝冰

分子量

1664.89

别名

Alaninamide;Bryamycin;Thiactin;NSC 81722;Thiostreptin A;NSC-170365;硫链丝菌素

溶解度

DMSO	98.0 mg/mL (58.9 mM)
Water	Insoluble

动物实验配方

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