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CAS No.: 65899-73-2

Tioconazole/噻康唑 Catalog No. CSN16446

Synonyms: UK-20349;Vagistat 1;UK-20,349

Tioconazole is an imidazole antifungal used to treat infections caused by a fungus or yeast, working by disrupting cell wall synthesis through inhibiting the biosynthesis of ergosterol or other sterols.

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技术信息

生物活性

描述Tioconazole, a substituted imidazole antimicrobial agent, have a broad spectrum of activity in vitro against dermatophytes and yeasts, as well as against some chlamydia, trichomonads and Gram-positive bacteria. Tioconazole is an effective and well tolerated treatment for vaginal candidiasis and superficial fungal infections of the skin^[3]. In vitro assays demonstrated that clinical yeasts were significantly more inhibited by tioconazole (MIC50, < or = 0.5 microgram/ml) than by fluconazole (MIC50, 8 micrograms/ml). Tioconazole also exhibited high potency against most molds (Alterneria spp. and Acremonium spp.). Vaginal fluid levels of tioconazole (mean, 91.4 micrograms/ml) persisted above the MIC90 levels (1-64 micrograms/ml) for most fungal and bacterial pathogens for 72 h in 19 evaluable female human subjects receiving 300 mg tioconazole in an intravaginal ointment^[4]. Tioconazole was found to inhibit activities of ATG4A and ATG4B (autophagy-related) with an IC50 of 1.3 µM and 1.8 µM, respectively. Moreover, tioconazole diminished tumor cell viability and sensitized cancer cells to autophagy-inducing conditions, including starvation and treatment with chemotherapeutic agents^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5792 mL
- 12.8962 mL
- 25.7924 mL
- 5 mM
- 0.5158 mL
- 2.5792 mL
- 5.1585 mL
- 10 mM
- 0.2579 mL
- 1.2896 mL
- 2.5792 mL

技术信息

CAS号

65899-73-2

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H13Cl3N2OS

运输

蓝冰

分子量

387.71

别名

UK-20349;Vagistat 1;UK-20,349;Gyno-Trosyd;Monistat 1-Day;Mykontral;Trosderm;Trosid;Trosyd;Trosyl;Vagistat;噻康唑

溶解度

DMSO	105.0 mg/mL (270.8 mM)
Water	insoluble

动物实验配方

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