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CAS No.: 475108-18-0
Synonyms: AV-951;KRN951;替沃扎尼
Tivozanib is an inhibitor of VEGFR1, VEGFR2 and VEGFR3 with IC50s of 30 nM, 6.5 nM, 15 nM, respectively. It can also inhibit PDGFR and c-Kit.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT03419572 | - | - | Recruiting | January 5, 2021 | - |
NCT00970411 | Solid Tumors | Phase 1 | Completed | - | Japan ... more >> Shizuoka, Japan Collapse << |
NCT01058655 | Gastrointestinal Cancer | Phase 1 Phase 2 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Collapse << |
实验方案
技术信息
CAS号 | 475108-18-0 | 储存条件 |
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分子式 | C22H19ClN4O5 | 运输 | 蓝冰 | |||||||||
分子量 | 454.86 | 别名 | AV-951;KRN951;替沃扎尼 | |||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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MCF7 cells | - | Proliferation assay | - | Antiproliferative activity against human MCF7 cells, IC50=0.38 μM | 24583357 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT03419572 | - | - | Recruiting | January 5, 2021 | - |
NCT00970411 | Solid Tumors | Phase 1 | Completed | - | Japan ... more >> Shizuoka, Japan Collapse << |
NCT01058655 | Gastrointestinal Cancer | Phase 1 Phase 2 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Collapse << |
NCT01631097 | Hepatic Impairment | Phase 1 | Completed | - | United States, Florida ... more >> Miami, Florida, United States Orlando, Florida, United States Collapse << |
NCT01058655 | - | - | Completed | - | - |
NCT01478594 | Colorectal Cancer | Phase 2 | Completed | - | - |
NCT01030783 | Advanced Renal Cell Carcinoma | Phase 3 | Completed | - | - |
NCT01076010 | Advanced Renal Cell Carcinoma | Phase 3 | Completed | - | - |
NCT01835223 | Advanced Adult Hepatocellular ... more >>Carcinoma Non-Resectable Hepatocellular Carcinoma Collapse << | Phase 1 Phase 2 | Active, not recruiting | December 1, 2019 | United States, New York ... more >> Roswell Park Cancer Institute Buffalo, New York, United States, 14263 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 Collapse << |
NCT01478594 | - | - | Completed | - | - |
NCT01745367 | Triple Negative Breast Cancer | Phase 2 | Terminated(low enrollment) | - | - |
NCT00502307 | Carcinoma, Renal Cell | Phase 2 | Completed | - | India ... more >> Vellore, Tamil Nadu, India, 632004 Kolkata, India Mumbai, India New Delhi, India Pune, India Russian Federation Astrakhan, Russian Federation Ioshkar-Ola, Russian Federation Kazan, Russian Federation Moscow, Russian Federation, 125284 Moscow, Russian Federation, 129128 Moscow, Russian Federation Novgorod, Russian Federation Obninsk, Russian Federation Pyatigorsk, Russian Federation Rostove-on-Don, Russian Federation Sochi, Russian Federation St. Petersburg, Russian Federation Tomsk, Russian Federation Ufa, Russian Federation Ukraine Cherkassy, Ukraine Dnepropetrovsk, Ukraine Donetsk, Ukraine Kharkov, Ukraine Lviv, Ukraine Uzhgorod, Ukraine Zaporizzhya, Ukraine Collapse << |
NCT01885949 | Prostate Cancer | Phase 2 | Active, not recruiting | June 2019 | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Collapse << |
NCT01782313 | Recurrent Adult Soft Tissue Sa... more >>rcoma Stage III Adult Soft Tissue Sarcoma Stage IV Adult Soft Tissue Sarcoma Collapse << | Phase 2 | Completed | - | United States, Illinois ... more >> Northwestern University Chicago, Illinois, United States, 60611 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52246 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Missouri Washington University Saint Louis, Missouri, United States, 63110 United States, Wisconsin University of Wisconsin Madison, Wisconsin, United States, 53792 Collapse << |
NCT01210846 | Advanced Solid Tumors | Phase 1 | Completed | - | United States, Arizona ... more >> TGEN Clinical Research Service at Scottsdale Healthcare Scottsdale, Arizona, United States United States, Florida Florida Cancer Specialists Ft. Myers, Florida, United States United States, Indiana Horizon Oncology Research, Inc. Lafayette, Indiana, United States United States, Louisiana Jayne Gurtler MD, Laura Brinz MD, Angelo Russo MD and Janet Burroff MD APMC Metairie, Louisiana, United States United States, Maryland Associates in Oncology/Hematology Rockville, Maryland, United States United States, Oklahoma Oklahoma University Cancer Institute (OUCI) Oklahoma City, Oklahoma, United States United States, Tennessee Tennessee Onocology Nashville, Tennessee, United States United States, Washington Multicare Research Institute/Tacoma General Hospital Tacoma, Washington, United States Collapse << |
NCT01782313 | - | - | Completed | - | - |
NCT00660153 | Colorectal Cancer ... more >> Gastrointestinal Cancer Collapse << | Phase 1 | Completed | - | Netherlands ... more >> University Medical Center Groningen; Internal Medicine, Department of Medical Oncology Groningen, Netherlands Erasmus Medical Center; Department of Medical Oncology Rotterdam, Netherlands Collapse << |
NCT01673386 | Metastatic Renal Cell Carcinom... more >>a Collapse << | Phase 2 | Completed | - | - |
NCT02627963 | Carcinoma, Renal Cell | Phase 3 | Active, not recruiting | December 2019 | - |
NCT01728181 | Non-small Cell Lung Cancer ... more >> Stage IV Disease EGFR Unknown or Wild-type Collapse << | Phase 1 Phase 2 | Withdrawn(Stopped before appro... more >>val due to ineffective drug) Collapse << | March 2016 | - |
NCT01369433 | Solid Tumors | Not Applicable | Completed | - | - |
NCT00563147 | Renal Cell Carcinoma | Phase 1 | Completed | - | United States, California ... more >> UCLA Jonsson Comprehensive Cancer Center Los Angeles, California, United States, 90095 Stanford University Stanford, California, United States, 94305 United States, Florida H. Lee Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, Nebraska Nebraska Methodist Hospital Omaha, Nebraska, United States, 68114 United States, Texas The Methodist Hospital Research Institute Houston, Texas, United States, 77030 Collapse << |
NCT01297244 | Renal Cell Carcinoma | Phase 2 | Completed | - | - |
NCT00717340 | Metastatic Breast Cancer | Phase 1 | Completed | - | United States, Massachusetts ... more >> Dana Farber Cancer Institute, Inc. Boston, Massachusetts, United States, 02115 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Germany Universitaetsklinikum Essen Essen, Germany, D-45147 Collapse << |
NCT00826878 | Carcinoma, Non-Small-Cell Lung | Phase 1 | Completed | - | United States, District of Col... more >>umbia Georgetown University Washington, District of Columbia, United States, 20007 United States, Kansas Kansas University Medical Center Kansas City, Kansas, United States, 66160 United States, New York Memorial Sloan-Kettering New York, New York, United States, 10021 Collapse << |
NCT01846871 | Glioblastoma | Phase 2 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Collapse << |
NCT01306630 | Advanced Solid Tumors ... more >> Locally Advanced or Metastatic Breast or Colorectal Cancer Collapse << | Phase 1 | Completed | - | United States, Arizona ... more >> Scottsdale, Arizona, United States, 85258 United States, Florida Fort Myers, Florida, United States, 33908 United States, Tennessee Nashville, Tennessee, United States, 37203 Collapse << |
NCT01769885 | Stage II Renal Cell Cancer ... more >> Stage III Renal Cell Cancer Collapse << | Not Applicable | Withdrawn | - | - |
NCT01363778 | Healthy | Phase 1 | Completed | - | United States, Wisconsin ... more >> Covance Clinical Research Unit, Inc. Madison, Wisconsin, United States, 53704 Collapse << |
NCT01972516 | Ovarian Cancer ... more >> Fallopian Tube Cancer Primary Peritoneal Carcinoma Collapse << | Phase 2 | Terminated(due to slow accrual... more >>) Collapse << | - | United States, Massachusetts ... more >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 Collapse << |
NCT01972516 | - | - | Terminated(due to slow accrual... more >>) Collapse << | - | - |
NCT01853644 | Recurrent Epithelial Ovarian C... more >>ancer Recurrent Fallopian Tube Cancer Recurrent Primary Peritoneal Cancer Collapse << | Phase 2 | Active, not recruiting | October 2019 | United States, Illinois ... more >> Northwestern University Chicago, Illinois, United States, 60611 CDH-Delnor Health System - Northwestern Medicine Cancer Center Warrenville, Illinois, United States, 60555 Collapse << |
NCT01363804 | Healthy | Phase 1 | Completed | - | United States, Florida ... more >> Covance Clinical Research Unit, Inc. Daytona Beach, Florida, United States, 32117 Collapse << |
NCT01834183 | Renal Cell Carcinoma | Phase 2 | Withdrawn(Sponsor Aveo has wit... more >>hdrawn support for this trial.) Collapse << | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Brigham and Women's Hospital Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 Collapse << |
NCT01807156 | - | - | Terminated(Primary endpoint no... more >>t met) Collapse << | - | - |
NCT01316848 | Food Effect of Tivozanib in He... more >>alth Subjects Collapse << | Phase 1 | Completed | - | United States, Texas ... more >> Covance Clinical Research Unit, Inc. Dallas, Texas, United States Collapse << |
NCT01807156 | Hepatocellular Cancer | Phase 2 | Terminated(Primary endpoint no... more >>t met) Collapse << | - | United States, Georgia ... more >> Emory University, Winship Cancer Institute Atlanta, Georgia, United States, 30322 Collapse << |
NCT03136627 | Carcinoma, Renal Cell | Phase 1 Phase 2 | Active, not recruiting | December 2018 | France ... more >> Bordeaux Hospital University Center (CHU) Bordeaux, France Center Léon Bérard Lyon, France Institut Paoli-Calmettes Marseille, France Centre Paul Strauss Strasbourg, France, 67065 Institut Gustave Roussy Villejuif, France, 94805 Collapse << |
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