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CAS No.: 36951-72-1

TMPyP4 tosylate Catalog No. CSN23169

Synonyms: TMP 1363;TMPyP4 (tosylate);TMPyP4 4-methylbenzenesulfonate

TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand, which inhibits the interaction between G-quadruplexes and IGF-1[1]. TMPyP4 tosylate (TMP 1363) is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines[2].

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生物活性

描述The biological functions of G-quadruplexes are closely related to the binding of some proteins. Insulin-like growth factor type I (IGF-1), as a significant modulator of cell growth and development, may serve as a quadruplex-binding protein.TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand, which inhibits the interaction between G-quadruplexes and IGF-1. IGF-1 shows a binding specificity for G-quadruplex structures, especially the G-quadruplex structure with a parallel topology. The quadruplex-specific ligands TMPyP4 and PDS (Pyridostatin) can inhibit the interaction between G-quadruplexes and proteins^[1]. TMPyP4 is a cationic porphyrin that intercalates into and stabilizes G-quadruplexes, which are formed by DNA and RNA sequences composed of blocks of guanine residues^[2]. TMPyP4 induces telomere shortening, and inhibition of the cell growth in HOS and Saos-2 with over 17% apoptosis rates.^[3]. TMPyP4 inhibits telomerase activity (IC50 ≤ 50 µM), blocking the clonogenic growth and migration of cancer cells in culture and in vivo^[4]. TMPyP4 potently suppressed cell viability and induced the apoptosis of SW480 cells in a dose-dependent manner. In addition, the downregulation of Wnt, β-catenin and cyclinD1 expression levels was detected in TMPyP4-treated SW480 cells.^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.7290 mL
- 3.6452 mL
- 7.2904 mL
- 5 mM
- 0.1458 mL
- 0.7290 mL
- 1.4581 mL
- 10 mM
- 0.0729 mL
- 0.3645 mL
- 0.7290 mL

技术信息

CAS号	36951-72-1	储存条件	粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C72H74N8O12S4	运输	蓝冰
分子量	1371.66	别名	TMP 1363;TMPyP4 (tosylate);TMPyP4 4-methylbenzenesulfonate;TMP-1363 tetratosylate

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