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CAS No.: 1156-19-0

Tolazamide/甲磺氮草脲 Catalog No. CSN12103

Synonyms: U-17835;NSC 70762;Tolinase

Tolazamide is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity.

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描述Tolazamide is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. Tolazamide had two general classes of binding sites (i.e., high and low affinity) for normal and glycated HSA. The higher affinity sites had binding constants of around 4.3-6.0 × 104 M-1 for these interactions at pH 7.4 and 37 °C, while the lower affinity sites had binding strengths of 4.9-9.1 × 103 M-1^[3]. Tolazamide in vitro alters postreceptor insulin action without influencing the receptor, and suggests insulin-stimulated hexose transport as the cellular process responsible for the hypoglycemic effect of sulfonyureas in adipose tissue^[4]. Tolazamide markedly enhances ECM (extracellular matrix) synthesis and accumulation in MCs (mesangial cells) probably by stimulating GLUT1 expression, glucose transport and TGF-beta 1 secretion, irrespective of the ambient glucose concentration. This effect was dose-dependent and minimally inducible by metformin^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02456428	-	-	Completed	-	Canada, Quebec ... more >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Collapse <<
NCT02476760	-	-	Completed	-	Canada, Quebec ... more >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Collapse <<
NCT02475499	-	-	Completed	-	Canada, Quebec ... more >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2113 mL
- 16.0565 mL
- 32.1131 mL
- 5 mM
- 0.6423 mL
- 3.2113 mL
- 6.4226 mL
- 10 mM
- 0.3211 mL
- 1.6057 mL
- 3.2113 mL

技术信息

CAS号

1156-19-0

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H21N3O3S

运输

蓝冰

分子量

311.40

别名

U-17835;NSC 70762;Tolinase;Norglycin;Tolanase;Tolazolamide;甲磺氮草脲

溶解度

DMSO	39.0 mg/mL (125.2 mM)

动物实验配方

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