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CAS No.: 59-97-2

Tolazoline HCl/盐酸妥拉唑林 Catalog No. CSN18767

Synonyms: Imidaline hydrochloride;NSC35110 hydrochloride;Tolazoline (hydrochloride)

Tolazoline HCl is a competitive non-selective α-adrenergic receptor antagonist, used as a a vasodilator directly acting on blood vessels and also increasing cardiac output.

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技术信息

生物活性

描述Tolazoline hydrochloride(HCl) is an alpha-adrenergic blocker. Administration of tolazoline hydrochloride to patients with cor pulmonale in the terminal stages of cystic fibrosis was associated with an improvement in the results of their lung function tests^[3]. Administration of 8.0 mg/kg tolazoline HCl as an antagonist significantly reduced immobilization times from 148.0 +/- 52.7 to 47.9 +/- 8.9 min. Respiratory rates also increased significantly after tolazoline HCl injection from 19 +/- 7 to 28 +/- 8 breaths/min. Immobilization resulted in an initial hypertension which was normalized after tolazoline HCl administration^[4].
参考文献

[1] Teskin O, Uydeş-Dogan BS, et al. Comparative effects of tolazoline and nitroprusside on human isolated radial artery. Ann Thorac Surg. 2006 Jan;81(1):125-31.
[2] Lei L, Vaghy PL, et al. Activation of L-type calcium channel by tolazoline derivatives: role of isothiocyanate moiety. J Cardiovasc Pharmacol. 1998 May;31(5):721-33.
[3] Feather EA, Russell G. Effect of tolazoline hydrochloride on sputum viscosity in cystic fibrosis. Thorax. 1970 Nov;25(6):732-6. doi: 10.1136/thx.25.6.732. PMID: 5494682; PMCID: PMC472217.
[4] Kreeger TJ, Seal US, Faggella AM. Xylazine hydrochloride-ketamine hydrochloride immobilization of wolves and its antagonism by tolazoline hydrochloride. J Wildl Dis. 1986 Jul;22(3):397-402. doi: 10.7589/0090-3558-22.3.397. PMID: 3735586.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.0845 mL
- 25.4224 mL
- 50.8449 mL
- 5 mM
- 1.0169 mL
- 5.0845 mL
- 10.1690 mL
- 10 mM
- 0.5084 mL
- 2.5422 mL
- 5.0845 mL

技术信息

CAS号

59-97-2

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H13ClN2

运输

蓝冰

分子量

196.68

别名

Imidaline hydrochloride;NSC35110 hydrochloride;Tolazoline (hydrochloride);AI3-52042;Arterodyl;Benzazoline hydrochloride;Benzylimidazoline hydrochloride;Benzylimidazoline HCl;Priscoline hydrochloride;Priscoline HCl;Tolavad;Tolazoline HCl;Tolpal;盐酸妥拉唑林

溶解度

DMSO	300.0 mg/mL (1525.3 mM) warming
Water	60.0 mg/mL (305.1 mM) warming

动物实验配方

0.5% CMC-Na

35 mg/mL

clear

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