|N-(4-(2-(二甲氨基)乙氧基)苄基)-3,4-二甲氧基苯甲酰胺盐酸盐|CsnPharm

CAS No.: 122892-31-3

topride HCl/盐酸依托必利 Catalog No. CSN16680

Synonyms: HSR803;Itopride (hydrochloride);N-((4-(2-(Dimethylamino)ethoxy)phenyl)methyl)-3,4-dimethoxybenzamide monohydrochloride

Itopride HCl is a D2 antagonist and an AChE inhibitor with an IC50 value of 2.04±0.27 μM. It is a prokinetic benzamide derivative unlike domperidone.

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靶点选择性

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实验方案

技术信息

生物活性

描述Itopride hydrochloride (itopride) inhibits acetylcholinesterase (AChE) and antagonizes dopamine D2 receptor, and has been used as a gastroprokinetic agent. In the ileum, itopride accelerated peristaltic velocity at higher dosage (10^-10-10^-6 M) and significantly shortened colonic transit^[3]. Itopride 100 mg t.i.d. is effective on decreasing pathologic reflux in patient with GERD (gastro-esophageal reflux disease)^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00599677	Functional Dyspepsia	Not Applicable	Completed	-	China, Sichuan ... more >> Chengdu University of TCM Chengdu, Sichuan, China, 610075 Collapse <<
NCT01332890	Healthy	Phase 1	Completed	-	Korea, Republic of ... more >> ASAN Medical Center, University of Ulsan Seoul, Korea, Republic of Collapse <<
NCT01513811	Constipation	Phase 2	Completed	-	China, Shanghai ... more >> Shanghai Jiao-Tong University School of Medicine Renji Hospital Shanghai, Shanghai, China, 200001 Collapse <<

更多
参考文献

[1] Scarpellini E, Vos R, et al. The effects of itopride on oesophageal motility and lower oesophageal sphincter function in man. Aliment Pharmacol Ther. 2011 Jan;33(1):99-105.
[2] Iwanaga Y, Kimura T, et al. Characterization of acetylcholinesterase-inhibition by itopride. Jpn J Pharmacol. 1994 Nov;66(3):317-22.
[3] Lim HC, Kim YG, Lim JH, Kim HS, Park H. Effect of itopride hydrochloride on the ileal and colonic motility in guinea pig in vitro. Yonsei Med J. 2008 Jun 30;49(3):472-8.
[4] Kim YS, Kim TH, Choi CS, Shon YW, Kim SW, Seo GS, Nah YH, Choi MG, Choi SC. Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study. World J Gastroenterol. 2005 Jul 21;11(27):4210-4.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5323 mL
- 12.6617 mL
- 25.3234 mL
- 5 mM
- 0.5065 mL
- 2.5323 mL
- 5.0647 mL
- 10 mM
- 0.2532 mL
- 1.2662 mL
- 2.5323 mL

技术信息

CAS号

122892-31-3

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H27ClN2O4

运输

蓝冰

分子量

394.89

别名

HSR803;Itopride (hydrochloride);N-((4-(2-(Dimethylamino)ethoxy)phenyl)methyl)-3,4-dimethoxybenzamide monohydrochloride;盐酸伊托必利

溶解度

DMSO	60.0 mg/mL (151.9 mM) warming
Water	200.0 mg/mL (506.5 mM)

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00599677	Functional Dyspepsia	Not Applicable	Completed	-	China, Sichuan ... more >> Chengdu University of TCM Chengdu, Sichuan, China, 610075 Collapse <<
NCT01332890	Healthy	Phase 1	Completed	-	Korea, Republic of ... more >> ASAN Medical Center, University of Ulsan Seoul, Korea, Republic of Collapse <<
NCT01513811	Constipation	Phase 2	Completed	-	China, Shanghai ... more >> Shanghai Jiao-Tong University School of Medicine Renji Hospital Shanghai, Shanghai, China, 200001 Collapse <<
NCT00112203	Dyspepsia	Phase 3	Completed	-	-
NCT00112177	Dyspepsia	Phase 3	Completed	-	Canada, Quebec ... more >> Monique Giguère, Ph.D. - Programs Director Mont-Saint-Hilaire, Quebec, Canada, J3H 6C4 Collapse <<
NCT00370084	Gastroparesis	Phase 1 Phase 2	Completed	-	Australia, South Australia ... more >> University of Adelaide, Department of Medicine Adelaide, South Australia, Australia, 5000 Collapse <<
NCT00110968	Dyspepsia	Phase 3	Completed	-	-
NCT00112190	Dyspepsia	Phase 3	Completed	-	Canada, Quebec ... more >> AXCAN Pharma Inc. Mont St-Hilaire, Quebec, Canada, J3H 6C4 Collapse <<
NCT00599677	Functional Dyspepsia	Not Applicable	Completed	-	China, Sichuan ... more >> Chengdu University of TCM Chengdu, Sichuan, China, 610075 Collapse <<
NCT01513811	Constipation	Phase 2	Completed	-	China, Shanghai ... more >> Shanghai Jiao-Tong University School of Medicine Renji Hospital Shanghai, Shanghai, China, 200001 Collapse <<
NCT00112190	Dyspepsia	Phase 3	Completed	-	Canada, Quebec ... more >> AXCAN Pharma Inc. Mont St-Hilaire, Quebec, Canada, J3H 6C4 Collapse <<
NCT00370084	Gastroparesis	Phase 1 Phase 2	Completed	-	Australia, South Australia ... more >> University of Adelaide, Department of Medicine Adelaide, South Australia, Australia, 5000 Collapse <<
NCT00112177	Dyspepsia	Phase 3	Completed	-	Canada, Quebec ... more >> Monique Giguère, Ph.D. - Programs Director Mont-Saint-Hilaire, Quebec, Canada, J3H 6C4 Collapse <<
NCT00110968	Dyspepsia	Phase 3	Completed	-	-
NCT01332890	Healthy	Phase 1	Completed	-	Korea, Republic of ... more >> ASAN Medical Center, University of Ulsan Seoul, Korea, Republic of Collapse <<
NCT00112203	Dyspepsia	Phase 3	Completed	-	-

topride HCl/盐酸依托必利 Catalog No. CSN16680

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