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CAS No.: 67684-64-4

trans-ACPD Catalog No. CSN16574

Synonyms: Trans-(±)-ACP;(±)-trans-ACP

trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons.

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技术信息

生物活性

描述Trans-ACPD is a selective agonist of the metabotropic glutamate receptor. Brief pulses of t-ACPD (< or = 100 mM, 1-5 s) consistently produced a large (200-600 nM) increase in dendritic Ca²⁺ that was sometimes followed by a somatic increase. Brief pulses of t-ACPD (10 mM) produced a small inward current that was associated with an increase in membrane conductance. The t-ACPD induced inward current was attenuated by substitution of external Na⁺ with Li⁺ or choline, or by application of the membrane-permeable Ca²⁺ chelator, bis-(2-aminophenoxy)-N,N,N',N'- tetraacetic acid (BAPTA)/AM^[3]. The concentrations of trans-ACPD required to evoke half-maximal stimulation (EC50 value) is 51 μM^[4]. L-AMPA responses were suppressed by trans-ACPD for various durations, with the longest duration about 60 min^[5]. One of the effects of trans-ACPD is stimulation of cAMP accumulation. trans-AC-PD was able to induce significant stimulation of cAMP accumulation in rat cerebral cortical slices, with ED50 of 47.8 mM^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.7748 mL
- 28.8739 mL
- 57.7479 mL
- 5 mM
- 1.1550 mL
- 5.7748 mL
- 11.5496 mL
- 10 mM
- 0.5775 mL
- 2.8874 mL
- 5.7748 mL

技术信息

CAS号

67684-64-4

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C7H11NO4

运输

蓝冰

分子量

173.17

别名

Trans-(±)-ACP;(±)-trans-ACP

溶解度

DMSO	50.0 mg/mL (288.7 mM) warming
Water	3.0 mg/mL (17.3 mM) warming

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trans-ACPD Catalog No. CSN16574

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