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CAS No.: 867164-40-7

TRC051384 Catalog No. CSN20345

Synonyms: TRC051384

TRC051384 is a inducer of Hsp70.

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生物活性

实验方案

技术信息

生物活性

描述TRC051384 is a potent inducer of HSP70 which can induce HSP70B mRNA expression. Dose-dependent increase of HSP70B can be observed on mRNA level in both HeLa and mixed neuronal cells exposure to 6.25μM and 12.5μM TRC051384 for 4h. Consistent with this, TRC051384 at 25μM can increase the transcriptional activity of HSF-1, the protein HSP70 as the chaperone responsible for, in luciferase assay reporter systems in HeLa cells, as well as lead to a significant recovery from a heat shock. Administration of TRC051384 intraperitoneally significantly reduced stroke associated neuronal injury and disability in a rat model of transient ischemic stroke. Meanwhile the enhanced expression of HSP70 can be observed in the affected region of rats dosed with TRC051384. Administration with 9mg/kg TRC051384 could delayed thrombus formation in mice.
参考文献

[1] Allende M, Molina E, et al. Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk. Cardiovasc Res. 2016 Jun 1;110(3):309-18.
[2] Mohanan A, Deshpande S, et al. Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. Neuropharmacology. 2011 May;60(6):991-9.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1480 mL
- 10.7401 mL
- 21.4802 mL
- 5 mM
- 0.4296 mL
- 2.1480 mL
- 4.2960 mL
- 10 mM
- 0.2148 mL
- 1.0740 mL
- 2.1480 mL

技术信息

CAS号

867164-40-7

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C25H31N5O4

运输

蓝冰

分子量

465.54

别名

TRC051384

溶解度

DMSO	77.0 mg/mL (165.4 mM)
Water	insoluble

动物实验配方

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