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CAS No.: 6807-83-6

Trifolirhizin/三叶豆紫檀苷 Catalog No. CSN19947

Synonyms: (–)-Maackiain-3-O-glucoside;Sophojaponicin B1;(−)-Maackiain 3-O-glucoside

Trifolirhizin is purified from the roots of sophora flavescens L. that possesses potential anti-inflammatory and anti-cancer activities.

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技术信息

生物活性

描述Trifolirhizin, a pterocarpan flavonoid, was isolated from the roots of Sophora flavescens. Trifolirhizin not only dose-dependently inhibited LPS-induced expression of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) but also inhibited lipopolysaccharide (LPS)-induced expression of cyclooxygenase-2 (COX-2). In addition, trifolirhizin showed in vitro inhibitory effects on the growth of human A2780 ovarian and H23 lung cancer cells^[2]. Trifolirhizin caused a significantly decreased proliferation of MKN45 cells in a time- and dose-dependent manner, with IC50 values of 33.27±2.06 µg/mL at 48 h^[3]. Moreover, trifolirhizin is an active constituent that inhibits acetylcholine mediated ASM (airway smooth muscle) contraction or directly relaxes pre-contracted ASM independent of β2-adrenoceptors^[4].
参考文献

[1] Yang N, Liang B, et al. The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contraction. Phytochemistry. 2013 Nov;95:259-67.
[2] Zhou H, Lutterodt H, Cheng Z, Yu LL. Anti-Inflammatory and antiproliferative activities of trifolirhizin, a flavonoid from Sophora flavescens roots. J Agric Food Chem. 2009;57(11):4580-4585
[3] Lu X, Ma J, Qiu H, Yang L, Cao L, Shen J. Anti-proliferation effects of trifolirhizin on MKN45 cells and possible mechanism. Oncol Rep. 2016;36(5):2785-2792
[4] Yang N, Liang B, Srivastava K, et al. The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contraction. Phytochemistry. 2013;95:259-267

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2401 mL
- 11.2006 mL
- 22.4012 mL
- 5 mM
- 0.4480 mL
- 2.2401 mL
- 4.4802 mL
- 10 mM
- 0.2240 mL
- 1.1201 mL
- 2.2401 mL

技术信息

CAS号

6807-83-6

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H22O10

运输

蓝冰

分子量

446.40

别名

(–)-Maackiain-3-O-glucoside;Sophojaponicin B1;(−)-Maackiain 3-O-glucoside;三叶豆紫檀苷

溶解度

DMSO	89.0 mg/mL (199.4 mM)

动物实验配方

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Trifolirhizin/三叶豆紫檀苷 Catalog No. CSN19947

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