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CAS No.: 13647-35-3

Trilostane/曲洛司坦 Catalog No. CSN12146

Synonyms: Win 24540;Modrastane;Modrefen

Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase for Cushing's syndrome.

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技术信息

生物活性

描述Trilostane is a recognized treatment for canine pituitary-dependent hyperadrenocorticism (PDH); The median survival time for animals treated with trilostane was 353 days (95% confidence interval [CI] 95-528 days)^[3]. During trilostane therapy, urinary catecholamines and their metabolites did not decrease significantly. However, dogs with low post-ACTH cortisol concentrations during trilostane therapy had less increased epinephrine, norepinephrine and normetanephrine, creatinine ratios compared to healthy dogs^[4]. In a substantial number of dogs treated with trilostane, the two prepill cortisol concentrations differed. Part of this difference might be ascribable to stressful events during test performance^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01615211	Medical Abortion, Complete or ... more >>Unspecified, Without Complication Collapse <<	Phase 2	Terminated(No access to study ... more >>drug Trilostan. Company closed down) Collapse <<	-	Sweden ... more >> Karolinska University Hospital Stockholm, Sweden, 17177 Collapse <<
NCT00181597	Prostate Cancer ... more >> Prostate Adenocarcinoma Collapse <<	Phase 2	Completed	-	United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0355 mL
- 15.1776 mL
- 30.3552 mL
- 5 mM
- 0.6071 mL
- 3.0355 mL
- 6.0710 mL
- 10 mM
- 0.3036 mL
- 1.5178 mL
- 3.0355 mL

技术信息

CAS号

13647-35-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H27NO3

运输

蓝冰

分子量

329.43

别名

Win 24540;Modrastane;Modrefen;Desopan;Vetoryl;WIN 24,540;DB01108;D-01180;Modrastane. Desopan;Modrenal;曲洛司坦

溶解度

DMSO	100.0 mg/mL (303.6 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	2 mg/mL	clear
PO	0.5% CMC-Na	42 mg/mL	suspension

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