|十八烷基三甲基溴化铵|CsnPharm

CAS No.: 1120-02-1

Trimethyloctadecylammonium bromide/十八烷基三甲基溴化铵 Catalog No. CSN23015

Synonyms: OctMAB

OctMAB is an inhibitor of dynamin I ( IC50 is 1.9 µM). It shows inhibition of receptor-mediated cell endocytosis.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The endocytic protein dynamin II (dynII) is a 100-kDa GTPase enzyme best known for its participation in cell cycle progression and role in centrosome cohesion and cytokinesis. Octadecyltrimethyl ammonium bromide (OctMAB) is a novel inhibitor of dynII GTPase activity with IC₅₀ value of 4.35 ± 2.42 μM. It also inhibits dynI GTPase activity with IC₅₀ value of 0.92 ± 0.13 μM. HeLa, H460, and SW480 cancer cells were treated with various concentrations of OctMAB for 7 d. Antiproliferative effect of OctMAB in these cells with a 50% reduction in colony formation was confiemed at concentration of ∼0.5 μM indicating OctMAB inhibited cell proliferation and reduce viability in a range of cancer cells. Asynchronously growing HeLa cells were treated for 48 h with OctMAB. Consistent with its effect on cell viability, it increased the sub-G₁ (<2N DNA content) population, indicating apoptosis. G₁ and S phase populations decreased, whereas the population of cells containing 4N DNA content (G₂-M) increased. Therefore, OctMAB disrupted cell cycle progression and caused cytokinesis failure ^[1].
作用机制OctMAB inhibits dynamin GTPase activity by disrupting the PH (pleckstrin homology) domain-phospholipid interaction ^[1].
参考文献

[1] Joshi S. The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Mol Cancer Ther. 2010 Jul;9(7):1995-2006. doi: 10.1158/1535-7163.MCT-10-0161.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5478 mL
- 12.7388 mL
- 25.4777 mL
- 5 mM
- 0.5096 mL
- 2.5478 mL
- 5.0955 mL
- 10 mM
- 0.2548 mL
- 1.2739 mL
- 2.5478 mL

技术信息

CAS号

1120-02-1

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H46BrN

运输

蓝冰

分子量

392.50

别名

OctMAB

溶解度

DMSO	11.0 mg/mL (28.0 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Trimethyloctadecylammonium bromide/十八烷基三甲基溴化铵 Catalog No. CSN23015

靶点选择性

请登录您的专属账户

确认信息