|(E)-4-(2-(5,5,8,8-四甲基-5,6,7,8-四氢萘-2-基)丙-1-烯-1-基)苯甲酸|CsnPharm

CAS No.: 71441-28-6

TTNPB (Arotinoid Acid)/维甲酸 Catalog No. CSN16014

Synonyms: Ro 13-7410;Arotinoid acid;AGN191183

TTNPB is an agonist of RAR and can inhibit binding of [3H]tRA with RARα (IC50 = 5.1 nM), RARβ (IC50 = 4.5 nM), and RARγ (IC50 = 9.3 nM).

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述TTNPB is a potent retinoic acid analog working as a selective agonist of RARs, with Ki values of 0.21, 0.43, and 0.22 nM for RARα, RARβ and RARγ, respectively. TTNPB is one of the most biologically active all-trans-retinoic acid (atRA) analogues but with highly teratogenic. It also works as an activator of UCP2 activity. TTNPB combined with other compound could enhance reprogramming efficiency in chemically induced pluripotent stem cells.
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
CV-1 cells	-	Function assay	-	Binding affinity against retinoic Acid gamma receptors co-transfected into CV-1 cells, EC50=0.002 Μm	8308867
HEK293 cells	-	Function assay	-	Agonist activity at human RARalpha expressed in HEK293 cells by luciferase reporter gene assay, EC50=0.18 nM	25305688
HeLa cells	-	Function assay	-	Agonist activity at human RARalpha expressed in human HeLa cells assessed as relative luminescence units at >=10 uM by luciferase assay relative to control	18951029

更多
动物研究
剂量
Mice: 0.01 mg/kg - 0.8 mg/kg^[3] (p.o.); 1 mg/kg, 10 mg/kg^[4] (i.p.)

给药途径
p.o., i.p.
参考文献

动物研究
剂量	Mice: 0.01 mg/kg - 0.8 mg/kg^[3] (p.o.); 1 mg/kg, 10 mg/kg^[4] (i.p.)
给药途径	p.o., i.p.

[1] Pignatello MA, Kauffman FC, et al. Multiple factors contribute to the toxicity of the aromatic retinoid TTNPB (Ro 13-7410): interactions with the retinoic acid receptors. Toxicol Appl Pharmacol. 1999 Sep 1;159(2):109-16.
[2] Pignatello MA, Kauffman FC, et al. Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410): binding affinities and disposition. Toxicol Appl Pharmacol. 1997 Feb;142(2):319-27.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8696 mL
- 14.3481 mL
- 28.6962 mL
- 5 mM
- 0.5739 mL
- 2.8696 mL
- 5.7392 mL
- 10 mM
- 0.2870 mL
- 1.4348 mL
- 2.8696 mL

技术信息

CAS号

71441-28-6

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H28O2

运输

蓝冰

分子量

348.48

别名

Ro 13-7410;Arotinoid acid;AGN191183

溶解度

DMSO	15.0 mg/mL (43.0 mM) warming
Water	Insoluble
Ethanol	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

TTNPB (Arotinoid Acid)/维甲酸 Catalog No. CSN16014

靶点选择性

请登录您的专属账户

确认信息