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CAS No.: 1310693-92-5

Tubastatin A HCl/Tubastatin A盐酸盐 Catalog No. CSN13649

Synonyms: Tubastatin A HCl;TSA HCl;Tubastatin A hydrochloride

Tubastatin A HCl is a potent and selective HDAC6 inhibitor with IC50 of 15 nM and is selective(1000-fold more) against all other isozymes except HDAC8(57-fold more).

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生物活性

实验方案

技术信息

生物活性

描述Tubastatin A hydrochloride is a potent and selective HDAC6 inhibitor with IC50 of 15 nM and is selective(1000-fold more) against all other isozymes except HDAC8(57-fold more).
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
134/04	7.5 µM	Function assay	-	impairs myotube formation	22174839
293T	~2 μg/ml	Function assay	-	induces PTEN expression and membrane translocation	26279303
293T	~2 μg/ml	Function assay	-	induces PTEN acetylation at K163	26279303

更多
参考文献

[1] Butler KV, Kalin J, et al. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J Am Chem Soc. 2010 Aug 11;132(31):10842-6.
[2] Butler KV, Kalin J, et al. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J Am Chem Soc. 2010 Aug 11;132(31):10842-6.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6892 mL
- 13.4459 mL
- 26.8918 mL
- 5 mM
- 0.5378 mL
- 2.6892 mL
- 5.3784 mL
- 10 mM
- 0.2689 mL
- 1.3446 mL
- 2.6892 mL

技术信息

CAS号

1310693-92-5

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H22ClN3O2

运输

蓝冰

分子量

371.86

别名

Tubastatin A HCl;TSA HCl;Tubastatin A hydrochloride

溶解度

DMSO	74.0 mg/mL (199.0 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

5%DMSO+40%PEG300+5%Tween80+50%water

5.5 mg/mL

大规格询价

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Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources

134/04	7.5 µM	Function assay	-	impairs myotube formation	22174839
293T	~2 μg/ml	Function assay	-	induces PTEN expression and membrane translocation	26279303
293T	~2 μg/ml	Function assay	-	induces PTEN acetylation at K163	26279303
C2C12	7.5 µM	Function assay	-	impairs myotube formation	22174839
CaSki	~5 μM	Function assay	-	induces the differential α-tubulin acetylation	23698468
CaSki	~5 μM	Function assay	-	inhibits Thapsigargin- or EGF-induced SOCE activation	23698468
CML-T1	10 μM	Function assay	-	enhances cell adhesivity to fibronectin	23022583
HaCaT keratinocytes	10 μM	Function assay	-	blocks arsenite from inducing Nrf2 protein translation	22367689
HEK293T	~3 μM	Function assay	-	up-regulated XBP1s protein level	24909686
HEK293T	~3 μM	Function assay	-	delays XBP1s protein degradation via acetylation-mediated proteasomal degradation	24909686
HL-60	10 μM	Function assay	-	enhances cell adhesivity to fibronectin	23022583
HT3	~5 μM	Function assay	-	induces the differential α-tubulin acetylation	23698468
Huh7	~5 μM	Function assay	-	suppresses proliferation of hepatitis C virus replicon with EC50 = 0.3 μM	25108326
IPC298	~3 μM	Function assay	-	augments expression of MHC class I and melanoma associated antigens	25957812
JURL-MK1	10 μM	Function assay	-	enhances cell adhesivity to fibronectin	23022583
K562	10 μM	Function assay	-	enhances cell adhesivity to fibronectin	23022583
KMCH	~10 μM	Growth inhibitory assay	-	decreases proliferation and anchorage-independent growth	23370327
MCF-7	30 μM	Growth inhibitory assay	-	IC50=15 μM	23798680
MCF-7	30 μM	Function assay	-	increases the microtubule acetylation level.	23798680
MCF-7	30 μM	Function assay	-	stabilizes microtubules against cold-induced depolymerization	23798680
MCF-7	15 μM	Function assay	-	stabilizes microtubules against nocodazole-induced disassembly	23798680
MCF-7	30 μM	Function assay	-	alteres the assembly dynamics of interphase microtubules	23798680
MCF-7	30 μM	Function assay	-	increases the binding of HDAC6 with interphase microtubules	23798680
neuron cultures	2.5 μM	Kinase assay	-	induces α-tubulin hyperacetylation	20614936
neuron cultures	~10 μM	Function assay	-	protects against glutathione depletion-induced oxidative stress	20614936
PC12	~3 μM	Function assay	-	up-regulates anti-oxidative gene expression related to transcription factor XBP1s	24909686
PC12	~3 μM	Growth inhibitory assay	-	reverse H2O2-induced growth inhibition	24909686
RAW 264.7	~10 μM	Function assay	-	attenuates NO production	23541634
SACC-83	~2 μg/ml	Function assay	-	induces PTEN expression and membrane translocation	26279303
SiHa	~5 μM	Function assay	-	induces the differential α-tubulin acetylation	23698468
SiHa	~5 μM	Function assay	-	inhibits Thapsigargin- or EGF-induced SOCE activation	23698468
SKMEL103	~500 nM	Growth inhibitory assay	-	inhibits cell proliferation	25957812
SKMEL21	~500 nM	Growth inhibitory assay	-	inhibits cell proliferation	25957812
SKMEL28	~500 nM	Growth inhibitory assay	-	inhibits cell proliferation	25957812
SKMEL30	~3 μM	Function assay	-	augments expression of MHC class I and melanoma associated antigens	25957812
TCa83	-	Function assay	-	induces PTEN expression and membrane translocation	26279303
THP-1	~10 μM	Function assay	-	inhibits TNF-α and IL-6 secretion	23541634
U-87 MG	~2 μg/ml	Function assay	-	inhibits the migration and invasion	26279303
U-87 MG	~10 μM	Function assay	-	inhibits AKT phosphorylation	26279303
U-87 MG	~10 μM	Growth inhibitory assay	-	inhibits cell growth	26279303
WM1361a	~500 nM	Growth inhibitory assay	-	inhibits cell proliferation	25957812
WM1366	~500 nM	Growth inhibitory assay	-	inhibits cell proliferation	25957812
WM164	~500 nM	Growth inhibitory assay	-	inhibits cell proliferation	25957812
WM164	~6 μM	Function assay	-	induce G1 arrest	25957812
WM164	~3 μM	Function assay	-	augments expression of MHC class I and melanoma associated antigens	25957812
WM35	~500 nM	Growth inhibitory assay	-	inhibits cell proliferation	25957812
WM793	~500 nM	Growth inhibitory assay	-	inhibits cell proliferation	25957812
WM793	~6 μM	Function assay	-	induce G1 arrest	25957812
WM983a	~500 nM	Growth inhibitory assay	-	inhibits cell proliferation	25957812
WM983a	~6 μM	Function assay	-	induce G1 arrest	25957812
WM983a	~3 μM	Function assay	-	augments expression of MHC class I and melanoma associated antigens	25957812

Tubastatin A HCl/Tubastatin A盐酸盐 Catalog No. CSN13649

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