|(2S,3S,4S,5R,6R)-6-(((((((2R,3S,4R,5R)-5-(2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)-3,4-二羟基四氢呋喃-2-基)甲氧基)氧化磷酰基)氧基)氧化磷酰基)氧基)-3,4,5-三羟基四氢-2H-吡喃-2-羧酸三钠盐|CsnPharm

CAS No.: 63700-19-6

UDP-glucuronic acid trisodium/尿苷二磷酸葡萄糖醛酸三钠 Catalog No. CSN29454

Synonyms: 尿苷二磷酸葡萄糖醛酸三钠;UDP-葡萄糖醛酸三钠

UDP-glucuronic acid trisodium is a critical precursor for essential glycoconjugates across biological kingdoms, ranging from mammalian glycosaminoglycans and plant cell wall polysaccharides to bacterial capsule glycoglycerolipids.

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技术信息

生物活性

描述UDP-glucuronic acid trisodium is a critical precursor for essential glycoconjugates across biological kingdoms, ranging from mammalian glycosaminoglycans and plant cell wall polysaccharides to bacterial capsule glycoglycerolipids^[1]. UDP-glucuronic acid (UDP-GlcA) is also common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively^[2]. UDP-glucuronic acid pyrophosphorylase from zebrafish has homology to bacterial nucleotidyltransferases and requires UTP as nucleosid diphosphate donor^[3]. Moreover, depletion of the hyaluronic acid precursor UDP-glucuronic acid is sufficient to inhibit several mesenchymal-like properties including cellular invasion and colony formation in vitro, as well as tumor growth and metastasis in vivo. And depletion of UDP-glucuronic acid altered the expression of PPAR-gamma target genes and increased PPAR-gamma DNA-binding activity^[4].
参考文献

[1] Li LX, Rautengarten C, Heazlewood JL, Doering TL. UDP-Glucuronic Acid Transport Is Required for Virulence of Cryptococcus neoformans. mBio. 2018 Jan 30;9(1):e02319-17
[2] Borg AJE, Dennig A, Weber H, Nidetzky B. Mechanistic characterization of UDP-glucuronic acid 4-epimerase. FEBS J. 2021 Feb;288(4):1163-1178
[3] Gangl R, Behmüller R, Tenhaken R. Molecular cloning of a novel glucuronokinase/putative pyrophosphorylase from zebrafish acting in an UDP-glucuronic acid salvage pathway. PLoS One. 2014 Feb 28;9(2):e89690
[4] Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, San Martin R, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 Apr;39(15):3089-3101

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.5474 mL
- 7.7372 mL
- 15.4743 mL
- 5 mM
- 0.3095 mL
- 1.5474 mL
- 3.0949 mL
- 10 mM
- 0.1547 mL
- 0.7737 mL
- 1.5474 mL

技术信息

CAS号	63700-19-6	储存条件	粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C15H19N2Na3O18P2	运输	蓝冰
分子量	646.23	别名	尿苷二磷酸葡萄糖醛酸三钠;UDP-葡萄糖醛酸三钠

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UDP-glucuronic acid trisodium/尿苷二磷酸葡萄糖醛酸三钠 Catalog No. CSN29454

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