CAS No.: 1532533-78-0
Umbralisib HCl/TGR-1202盐酸盐 Catalog No. CSN17911
Synonyms: TGR-1202 hydrochloride;RP5264 hydrochloride;RP-5264 HCl
TGR-1202 HCl is an orally available, next generation PI3Kdelta inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02793583 Diffuse Large B-Cell Lymphoma ... more >> Follicular Lymphoma Marginal Zone Lymphoma Small Lymphocytic Lymphoma Mantle Cell Lymphoma Collapse << Phase 2 Phase 3 Recruiting July 2019 - NCT02006485 Chronic Lymphocytic Leukemia ... more >> Non-Hodgkin's Lymphoma Collapse << Phase 1 Active, not recruiting July 2019 United States, Alabama ... more >> TG Therapeutics Investigational Trial Site Huntsville, Alabama, United States, 35805 United States, Arkansas TG Therapeutics Investigational Trial Site Jonesboro, Arkansas, United States, 72401 United States, California TG Therapeutics Investigational Trial Site Duarte, California, United States, 91010 United States, Georgia TG Therapeutics Investigational Trial Site Atlanta, Georgia, United States, 30322 United States, Nebraska TG Therapeutics Investigational Trial Site Omaha, Nebraska, United States, 68198 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << NCT03269669 Grade 1 Follicular Lymphoma ... more >> Grade 2 Follicular Lymphoma Grade 3a Follicular Lymphoma Recurrent Follicular Lymphoma Refractory Follicular Lymphoma Collapse << Phase 2 Recruiting December 31, 2022 - - 更多
- 参考文献
- [1] Deng C, Lipstein MR, et al. Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies. Blood. 2017 Jan 5;129(1):88-99.
- [2] Locatelli SL, Careddu G, et al. The novel PI3K-δ inhibitor TGR-1202 enhances Brentuximab Vedotin-induced Hodgkin lymphoma cell death via mitotic arrest. Leukemia. 2016 Dec;30(12):2402-2405.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1532533-78-0 | 储存条件 |
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| 分子式 | C31H25ClF3N5O3 | 运输 | 蓝冰 | |
| 分子量 | 608.01 | 别名 | TGR-1202 hydrochloride;RP5264 hydrochloride;RP-5264 HCl;TGR-1202 HCl |
