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CAS No.: 1429881-91-3
Synonyms: UNC2025
UNC2025 is an inhibitor of Mer and Flt3 with IC50 of 0.8 nM and 0.74 nM, respectively.
生物活性
靶点 | FLT3 IC50:0.74nM | Mer IC50:0.8nM |
实验方案
技术信息
CAS号 | 1429881-91-3 | 储存条件 |
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分子式 | C28H40N6O | 运输 | 蓝冰 | |||||||
分子量 | 476.66 | 别名 | UNC2025 | |||||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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32D cells | - | Function assay | 1 h | Inhibition of EGFR extracellular/transmembrane domain-tagged Mer intracellular domain (unknown origin) expressed in 32D cells assessed as inhibition EGF-stimulated of phosphorylation pretreated for 1 hr prior to EGF stimulation by Western blot analysis, IC50=2.7 nM | 25068800 |
697 cells | - | Function assay | 1 h | Inhibition of Mer phosphorylation in human 697 cells preincubated for 1 hr by densitometry, IC50=2.7 nM | 25068800 |
A549 cells | 50-300 nM | Function assay | - | Inhibition of Mer-mediated colony formation in human A549 cells at 50 to 300 nM measured after 2 weeks by soft agar colony formation assay | 25068800 |
Molm-14 cells | - | Function assay | 1 h | Inhibition of Flt3 phosphorylation in human Molm-14 cells preincubated for 1 hr by densitometry, IC50=0.014 μM | 25068800 |
靶点 | Description | IC50 |
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FLT3 | IC50:0.74nM | |
Mer | IC50:0.8nM |
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