生物活性

• 描述AIDA is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a), having no effect on group II (mGlu2) or group III (mGlu4) receptors expressed individually in baby hamster kidney cells.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02945722	Hemodialysis Patients	Phase 4	Recruiting	November 30, 2020	France ... more >> CH d'Annecy-Genevois Not yet recruiting Annecy, France Principal Investigator: Benoît FRANKO, MD          Ch Annonay Not yet recruiting Annonay, France Principal Investigator: Carole DEPRELE, MD          Ch Cannes Not yet recruiting Cannes, France Principal Investigator: Manuela DODOI, MD          AGDUC Not yet recruiting La Tronche, France Principal Investigator: Nadège MINGAT, MD          CH Emile Roux Not yet recruiting Le Puy-en-Velay, France Principal Investigator: Marc BOUILLER, MD          Sub-Investigator: Viorica BARBU, MD          Aural Not yet recruiting Lyon, France Principal Investigator: Jean-Christophe SZELAG, MD          CH St-Joseph St-Luc Not yet recruiting Lyon, France Principal Investigator: Cécile CHAUVET, MD          CHU Lyon Not yet recruiting Lyon, France Principal Investigator: Laurent JUILLARD, MD          AIDER Santé Not yet recruiting Montpellier, France Principal Investigator: Nathalie RAYNAL, MD          Sub-Investigator: Cécile GUIRAUD, MD          CH Roanne Not yet recruiting Roanne, France Principal Investigator: Aurore SURY, MD          ARTIC42 Recruiting Saint Etienne, France Principal Investigator: Jacques JURINE, MD          Sub-Investigator: Aida AFIANI, MD          Sub-Investigator: Linda AZZOUZ, MD          Sub-Investigator: Aline CHABROUX-SEFFERT, MD          Chu Saint-Etienne Recruiting Saint-etienne, France Principal Investigator: Elisabeth BOTHELO-NEVERS, MD          Sub-Investigator: Amandine GAGNEUX-BRUNON, MD          Sub-Investigator: Fréderic LUCHT, MD          Sub-Investigator: Philippe BERTHELOT, MD          Sub-Investigator: Florence GRATTARD, MD          Sub-Investigator: Paul VERHOEVEN, MD          Sub-Investigator: Anne CARRICAJO, MD          Sub-Investigator: Damien THIBAUDIN, MD          Sub-Investigator: Eric ALAMARTINE, MD          Sub-Investigator: Christophe MARIAT, MD          Sub-Investigator: Hesham MOHEY, MD          NephroCare Not yet recruiting Sainte-foy-les-Lyon, France Principal Investigator: Manolie MEHDI, MD Collapse <<
  NCT00041626	Carcinoma, Squamous Cell	Phase 3	Unknown	-	United States, Arkansas ... more >> University of Arkansas Recruiting Little Rock, Arkansas, United States, 72205 Contact: Karen Duvall    501-526-7129    kaduvall@uams.edu    Principal Investigator: James Suen, MD          United States, Colorado Unversity of Colorado Cancer Center Recruiting Aurora, Colorado, United States, 80045 Contact: Brittney Hines    720-848-0678    Brittany.Hines@uchsc.edu    Principal Investigator: Madeleine Kane, MD          United States, Florida University of Miami Hospital and Sylvester Comprehensive Cancer Center Recruiting Miami, Florida, United States, 33136 Contact: Andrea Gachupin-Garcia    305-243-3379    agachupin@med.miami.edu    Principal Investigator: Jarrad Goodwin, MD          United States, Kentucky Norton Healthcare Pavilion Recruiting Louisville, Kentucky, United States, 40202 Contact: Daniela Neamtu    502-629-4679    daniela.neamtu@nortonhealthcare.org    Principal Investigator: John Hamm, MD          United States, Maryland Center Center of GBMC Recruiting Baltimore, Maryland, United States, 21204 Contact: Lauren Titus    443-849-3285    ltitus@gbmc.org    Principal Investigator: Marshall Levine, MD          United States, South Carolina WJB Dorn VA Medical Center Recruiting Columbia, South Carolina, United States, 29209 Contact: Justin Reynolds    803-776-4000 ext 6074    Justin.Reynolds@va.gov    Principal Investigator: William Hrushesky, MD          United States, Texas Mary Crowley Medical Research Center Recruiting Dallas, Texas, United States, 75201 Contact: Arlen Waclawczyk    214-658-1985    awaclawczyk@mcmrc.com    Principal Investigator: John Nemunaitis, MD          University of Texas, MD Andersen Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Aida Berryman    713-745-1428    atberryman@mdanderson.org    Principal Investigator: Gary Clayman, MD Collapse <<
  NCT02796261	Anaplastic Astrocytoma ... more >> Recurrent Anaplastic Astrocytoma Collapse <<	Phase 3	Recruiting	August 2019	-

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• 参考文献

• [1] Zheng LS, Liu YT, et al. Structure and mechanism of the unique C2 domain of Aida. FEBS J. 2014 Oct;281(20):4622-32.

  [2] Kassin M, De Castro F, et al. Psychometric properties of a culture-adapted Spanish version of AIDA (Assessment of Identity Development in Adolescence) in Mexico. Child Adolesc Psychiatry Ment Health. 2013 Jul 31;7:25.