|3-[4-羟基-3-[5,6,7,8-四氢-5,5,8,8-四甲基-3-(戊基氧基)-2-萘]苯基]-2-丙酸|CsnPharm

CAS No.: 847239-17-2

UVI 3003 Catalog No. CSN23178

Synonyms: UVI 3003

UVI 3003 is a potent and selective RXR antagonist, used as a tool to test the contribution of RXR to transactivation by a given RXR heterodimer.

规格	价格	促销价格	库存	数量

400-920-2911

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tech@csnpharm.cn

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生物活性

实验方案

技术信息

生物活性

描述Retinoid X receptors occupy a central position in the nuclear receptor superfamily for the heterodimers formed by RXRs with many other family members are involved in the control of a variety of (patho)physiologic processes. UVI 3003 is a potent and selective RXR antagonist, used as a tool to test the contribution of RXR to transactivation by a given RXR heterodimer. UVI 3003 at concentration of 10μM could almost completely reverse depression of proliferation and increased apoptosis by combined RAR and RXR agonists in PLB985 cells in 12 days, but did not significantly affect growth inhibition or apoptosis in NB4 cells exposed to RAR agonists possibly because of the obliteration of the RXR requirement for apoptosis due to PML-RAR fusion protein. UVI 3003 can fully antagonize CD3254, a potent RXR agonist, induced transcription through Gal4-RXR in HeLa cells stably transfected with the reporter recombinant 5xGal4-βGlo-Luc and Gal4-hRXRβ.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2905 mL
- 11.4526 mL
- 22.9051 mL
- 5 mM
- 0.4581 mL
- 2.2905 mL
- 4.5810 mL
- 10 mM
- 0.2291 mL
- 1.1453 mL
- 2.2905 mL

技术信息

CAS号

847239-17-2

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C28H36O4

运输

蓝冰

分子量

436.58

别名

UVI 3003

溶解度

DMSO	65.0 mg/mL (148.9 mM)
Water	insoluble

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