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CAS No.: 722456-31-7

VAS2870 Catalog No. CSN21151

Synonyms: VAS2870

VAS2870 is a specific and effect NADPH oxidase inhibitor with IC50 value of 10.6 µM against NOX activity in human neutrophil lysates.

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400-920-2911

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述VAS2870 is a novel Nox inhibitor with IC50 vaue of 10.6μM for inhibition of NAD(P)H oxidase activity in a cell-free system with membranes and cytosol from human neutrophils. Pre-incubation with VAS2870 at concentration of 10μM and 20μM for 20min completely abolished PDGF-mediated NAD(P)H oxidase activation and ROS production in VSMC, as well as suppressed PDGF-mediated chemotaxis. VAS2870 at concentration of 5μM reduced oxLDL-stimulated ROS formation by about 70% in primarily cultured HUVEC without significant effect on mRNA expression of NAD(P)H oxidase subunit Nox4. VAS2870 at concentration of 25μM inhibited cell growth and ROS production of FaO rat hepatoma cells, and the much lower expression of cyclin D1, EGFR and TGF-α at the mRNA level as well as decreased phosphorylation of the EGFR, SRC and AKT could be observed post 12-hour treatment prior to serum depletion. Also VAS2870 inhibited both autocrine and serum-mediated cell growth of different human hepatocellular carcinoma (HCC) cell lines, including Hep3B, HepG2, SKHep1 and PLC/PRF5 cells. Pre-treatment with 25μM VAS2870 for 30min prior to TGF-β could enhance TGF-β-induced apoptosis in FaO cells starved for 12h.
动物研究
剂量
Rat: 2 mg/kg^[1] (i.v.) Mice: 10 mg/kg^[2] (i.p.), 25 mg/kg (i.p.)

给药途径
i.v., i.p.

动物研究
剂量	Rat: 2 mg/kg^[1] (i.v.) Mice: 10 mg/kg^[2] (i.p.), 25 mg/kg (i.p.)
给药途径	i.v., i.p.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7748 mL
- 13.8738 mL
- 27.7475 mL
- 5 mM
- 0.5550 mL
- 2.7748 mL
- 5.5495 mL
- 10 mM
- 0.2775 mL
- 1.3874 mL
- 2.7748 mL

技术信息

CAS号

722456-31-7

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H12N6OS

运输

蓝冰

分子量

360.39

别名

VAS2870

溶解度

DMSO	50.0 mg/mL (138.7 mM)

动物实验配方

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