|(2S)-1-((2S,5S)-2-(9-(2-((2S,4S)-1-((2R)-2-((甲氧基羰基)氨基)-2-苯基乙酰基)-4-(甲氧基甲基)吡咯烷-2-基)-1H-咪唑-5-基)-1,11-二氢异苯并吡喃并[4',3':6,7]萘并[1,2-d]咪唑-2-基)-5-甲基吡咯烷-1-基)-3-甲基-1-氧代丁-2-基)氨基甲酸甲酯|CsnPharm

CAS No.: 1377049-84-7

Velpatasvir/维帕他韦 Catalog No. CSN17357

Synonyms: GS-5816;维帕他韦

Velpatasvir is an inhibitor of hepatitis C virus nonstructural protein 5A (NS5A) (genotype 1 (GT1) to GT6 replicons).

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Chronic hepatitis C virus (HCV) infection afflicts an estimated 71 million individuals worldwide and leads to significant morbidity and mortality, including liver cirrhosis and hepatocellular carcinoma. HCV is comprised of six main genotypes and 86 known subtypes. Further, within these subtypes there are multiple resistance associated substitutions (RAS, plural RASs) in the HCV genome measurable at baseline or appearing during or after treatment^[4]. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons^[5]. The replicon EC50 values (effective concentration to inhibit viral replication by 50%) for velpatasvir, GT(EC50 value): 1a (14 pM); 1b (16 pM); 2a JFH1 (8 pM); 2a J6 (16 pM); 2b (6 pM); 3a (4 pM); 4a (9 pM); 5a (54 pM); 6a (6 pM); 6e (130 pM)^[4]. In human liver microsomes, velpatasvir shows no measureable disappearance of parent during a 60 min incubation, leading to a Pred CL < 0.16 L/h/kg. In cryopreserved human he-patocytes ³H-velpatasvir undergoes minimal metabolism and the Pred CL is exceedingly low at 0.06 L/h/kg (4.7% hepatic extraction, Eh%)^[4]. The percent free drug in plasma measured by dialysis is similar across species ranging from 0.2 to 0.4% free for rat, dog and cyno; human is within this range at 0.3% free. The steady-state volume of distribution (V_ss) is similar across the preclinical species and is larger than total body water ranging from 1.4 to 1.6 L/kg. The half-lives of velpatasvir are 2.3, 5.2 and 5.0h in rat, dog and cyno respectively^[4].

动物研究

剂量

Mice: 30 mg/kg - 1000 mg/kg^[3] (p.o.) Rat: 10 mg/kg - 600 mg/kg^[3] (p.o.)

给药途径

p.o.

动物药代数据

Animal	Mice^[3]	Rats^[3]	Dogs^[3]
Dose	100 mg/kg	1.0 mg/kg (i.v.) 2.0 mg/kg (p.o.)	0.25 mg/kg (i.v.) 0.5 mg/kg (p.o.)
Administration	p.o.	i.v. p.o.	i.v. p.o.
F		27.7 ± 18.7 h (p.o.)	25.0 ± 12.9 h (p.o.)
MRT		1.72 ± 0.18 h (i.v.)	5.70 ± 0.70 h (i.v.)
T_1/2		2.36 ± 0.26 h (i.v.) 2.33 ± 0.38 h (p.o.)	5.51 ± 0.46 h (i.v.) 9.1 ± 5.1 h (p.o.)
T_max		0.48 ± 0.0 h (i.v.) 1.0 ± 0.0 h (p.o.)	0.48 ± 0.0 h (i.v.) 1.3 ± 0.6 h (p.o.)
AUC_0→∞		1320 ± 240 h (i.v.) 709 ± 478 h (p.o.)	1010 ± 187 h (i.v.) 585 ± 343 h (p.o.)
AUC_0→24h	107 μ·h/ml
AUC_0→last		1320 ± 239 h (i.v.) 670 ± 435 h (p.o.)	931 ± 217 nM·h (i.v.) 490 ± 252 nM·h (p.o.)
C_max	8.57 μg/ml	1210 ± 433 h (i.v.) 116 ± 53 h (p.o.)	448 ± 157 nM (i.v.) 71.3 ± 27.2 nM (p.o.)
CL		0.94 ± 0.19 L/h/kg (i.v.)	0.25 ± 0.04 L/h/kg (i.v.)
Vss		1.61 ± 0.31 L/kg (i.v.)	1.46 ± 0.43 L/kg (i.v.)

临床研究
NCT号适应症或疾病临床期招募状态预计完成时间地点
NCT01457768 - - Completed - -
NCT03423641 - - Completed - -
NCT01858766 - - Completed - -
更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.1325 mL
- 5.6625 mL
- 11.3250 mL
- 5 mM
- 0.2265 mL
- 1.1325 mL
- 2.2650 mL
- 10 mM
- 0.1133 mL
- 0.5663 mL
- 1.1325 mL

技术信息

CAS号

1377049-84-7

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C49H54N8O8

运输

蓝冰

分子量

883.00

别名

GS-5816;维帕他韦

溶解度

DMSO	130.0 mg/mL (147.2 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+30% PEG300+water	5 mg/mL	clear
PO	0.5% CMC-Na	31 mg/mL	suspension

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01457768	-	-	Completed	-	-
NCT03423641	-	-	Completed	-	-
NCT01858766	-	-	Completed	-	-
NCT02333292	-	-	Recruiting	December 2020	Spain ... more >> Valme University Hospital Recruiting Seville, Andalusia, Spain, 41014 Contact: Karin I Neukam, Dr 0034955015871 karin.neukam@gmail.com Contact: Juan A Pineda, Dr 0034955015684 japineda@telefonica.net Collapse <<
NCT03625687	Respiratory Failure ... more >> Hepatitis C Collapse <<	Phase 4	Not yet recruiting	April 30, 2021	United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Collapse <<
NCT03208127	End Stage Liver Disease ... more >> Hepatitis C Collapse <<	Phase 4	Recruiting	September 1, 2020	United States, Massachusetts ... more >> Masschusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Jenna L Gustafson, MS 617-724-3836 jlgustafson@partners.org Contact: Raymond T Chung, MS rchung@partners.org Sub-Investigator: Emily Bethea, MD Collapse <<
NCT02824640	Hepatitis C M... more >>edication Adherence Collapse <<	Not Applicable	Recruiting	October 31, 2021	United States, New York ... more >> Alain Litwin Recruiting Bronx, New York, United States, 10467 Contact: Alain Litwin, MD, MPH, MSc 864-455-6658 alitwin@ghs.org Contact: Linda Agyemang, MPH 6467719536 lagyeman@montefiore.org Collapse <<
NCT01457755	-	-	Completed	-	-
NCT02057003	-	-	Recruiting	December 2020	Spain ... more >> Valme University Hospital Recruiting Seville, Spain, 41014 Contact: Karin Neukam, PhD 0034955015799 karin.neukam@gmail.com Contact: Juan A Pineda, MD 0034955015684 japineda@telefonica.net Collapse <<
NCT02202980	Chronic Hepatitis C	Phase 2	Completed	-	New Zealand ... more >> Auckland, New Zealand Christchurch, New Zealand Collapse <<
NCT01826981	Chronic Hepatitis C	Phase 2	Completed	-	New Zealand ... more >> Auckland Clinical Studies Ltd. Auckland, New Zealand Christchurch Clinical Studies Trust Christchurch, New Zealand Collapse <<
NCT03164902	Hepatitis C, Chronic ... more >> Nonadherence, Patient Collapse <<	Not Applicable	Active, not recruiting	April 30, 2019	United States, Alabama ... more >> University of Alabama Birmingham, Alabama, United States, 35294 United States, California Zuckerberg San Francisco General Hospital San Francisco, California, United States, 94110 United States, Colorado Peak Gastroenterology Associates Colorado Springs, Colorado, United States, 80907 Denver Health Denver, Colorado, United States, 80204 United States, District of Columbia Providence Health System Washington, District of Columbia, United States, 20017 United States, Florida Orlando Immunology Center Orlando, Florida, United States, 32803 Apex Clinical Research Tampa, Florida, United States, 33612 United States, Illinois The Ruth M. Rothstein CORE Center Chicago, Illinois, United States, 60637 United States, Maryland Johns Hopkins University Baltimore, Maryland, United States, 21205 United States, Massachusetts The Research Institute Springfield, Massachusetts, United States, 01105 United States, Michigan Harper University Hospital Detroit, Michigan, United States, 48201 Henry Ford Health System Detroit, Michigan, United States, 48202 United States, New Mexico Southwest Care Center Santa Fe, New Mexico, United States, 87502 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Washington Harborview Medical Center Seattle, Washington, United States, 98104 United States, Wisconsin SSM Health Dean Medical Group Madison, Wisconsin, United States, 53713 Collapse <<
NCT02202980	-	-	Completed	-	-
NCT03702218	Hepatitis C	Early Phase 1	Not yet recruiting	December 31, 2019	United States, Maryland ... more >> University of Maryland Medical Center Not yet recruiting Baltimore, Maryland, United States, 21201 Contact: David Bruno, MD dbruno@som.umaryland.edu Collapse <<
NCT03483987	Chronic Hepatitis C	Not Applicable	Recruiting	October 9, 2021	India ... more >> Sanjay Gandhi Postgraduate Institute of Medical Sciences Recruiting Lucknow, UP, India, 226014 Contact: Amit Goel, DM 9936275741 RML Institute of Medical Sciences Recruiting Lucknow, Uttar Pradesh, India Contact: Amit Goel +91-522249 ext 5548 agoel.ag@gmail.com Collapse <<
NCT03579576	-	-	Recruiting	June 2019	Myanmar ... more >> Waimaw Recruiting Kāchen, Kachin, Myanmar Contact: Aung Yu Naing, MD aungyunaing@gmail.com Contact: Nay Myo Aung, MD +95 (0)9970569186 naymyoaung@cpintl.org Myanmar Liver Foundation Clinic Completed Mandalay, Myanmar Myanmar Liver Foundation Charity Clinic Completed Yangon, Myanmar Collapse <<
NCT02510300	-	-	Enrolling by invitation	September 2027	-
NCT03249194	Kidney Transplant ... more >> Hepatitis C Collapse <<	Early Phase 1	Active, not recruiting	June 30, 2022	United States, Virginia ... more >> Virginia Commonwealth University Richmond, Virginia, United States, 23298 Collapse <<
NCT03383419	Heart Failure	Phase 2	Recruiting	December 31, 2020	United States, California ... more >> Cedars-Sinai Medical Center Not yet recruiting Los Angeles, California, United States, 90048 Contact: Dalia Galvan Tavera 310-248-7129 Dalia.GalvanTavera@csmns.org Principal Investigator: Evan Kransdorf, MD United States, North Carolina Duke University Medical Center Not yet recruiting Durham, North Carolina, United States, 27705 Contact: Jennifer Wilson 919-668-8222 J.wilson@duke.edu Principal Investigator: Chet Patel, MD United States, Texas Baylor University Medical Center Recruiting Dallas, Texas, United States, 75246 Contact: Katalin Martits-Chalangari, MD 214-820-1722 KATALIN.MARTITSCHALANGARI@BSWHealth.org Principal Investigator: Robert Gottlieb, MD Collapse <<
NCT01826981	-	-	Completed	-	-
NCT02657694	-	-	Enrolling by invitation	June 30, 2018	Australia, Tasmania ... more >> FixHepC Hobart, Tasmania, Australia, 7004 Collapse <<
NCT03207399	Hepatitis C, Chronic ... more >> Lung Transplant Collapse <<	Phase 4	Recruiting	September 15, 2019	United States, North Carolina ... more >> Duke University Medical Center Recruiting Durham, North Carolina, United States, 27710 Contact: Noely M Martinez Overby 919-681-3791 noely.martinez-overby@duke.edu Principal Investigator: Alice Gray, MD Collapse <<
NCT03377478	Hepatits C Lu... more >>ng Transplant Collapse <<	Phase 1	Not yet recruiting	February 1, 2020	United States, Pennsylvania ... more >> UPMC Not yet recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: Jonathan D'Cunha, MD, PhD 412-648-6315 dcunhaj@upmc.edu Contact: Pablo Sanchez, MD 412-648-6315 sanchezpg@upmc.edu Collapse <<
NCT03226717	-	-	Not yet recruiting	December 10, 2017	Egypt ... more >> yasmin AbdElazim Mohamed Turkey Recruiting Assiut, Egypt Collapse <<
NCT02625909	Hepatitis C	Phase 3	Recruiting	August 2020	United States, Massachusetts ... more >> Massachusetts General Hospital Not yet recruiting Boston, Massachusetts, United States, 02114-2621 Contact: Arthur Kim, MD 617-726-3906 AKIM1@mgh.harvard.edu Australia, New South Wales Kirketon Road Centre Recruiting Sydney, New South Wales, Australia, 1340 Contact: Phillip Read, MBBS, MPH +61 2 9360 2766 Phillip.Read@SESIAHS.HEALTH.NSW.GOV.AU St. Vincent's Hospital Recruiting Sydney, New South Wales, Australia, 2010 Contact: Gregory J Dore, MBBS, PhD +61 2 9385 0898 gdore@kirby.unsw.edu.au Contact: Rebecca Hickey +61 2 8382 3825 Rebecca.Hickey@svha.org.au The Kirby Institute, University of New South Wales Australia Not yet recruiting Sydney, New South Wales, Australia, 2052 Contact: Gail V Matthews, MbChB, PhD +61 2 9385 0900 gmatthews@kirby.unsw.edu.au Contact: Sophia Amjad +61 2 9385 2216 samjad@kirby.unsw.edu.au Australia, South Australia Royal Adelaide Hospital Recruiting Adelaide, South Australia, Australia, 5000 Contact: David Shaw, MBBS +61 8 8222 5634 david.shaw@health.sa.gov.au Australia, Victoria The Alfred Hospital Recruiting Melbourne, Victoria, Australia, 3004 Contact: Margaret Hellard, MBBS, PhD +61 3 9282 2163 hellard@burnet.edu.au Royal Melbourne Hospital Recruiting Melbourne, Victoria, Australia, 3050 Contact: Joe Sasadeusz, MBBS, PhD +613 9342 7000 J.Sasadeusz@mh.org.au Canada, Ontario Toronto General Hospital Recruiting Toronto, Ontario, Canada, ON M57 2S8 Contact: Jordan J Feld, MD +416 603 6230 Jordan.Feld@uhn.ca Canada, Quebec Centre Hospitalier de l' Universite de Montreal Recruiting Montreal, Quebec, Canada, QC H2X 1P1 Contact: Julie Bruneau, MD +514 890 8000 ext 35713 julie.bruneau@umontreal.ca Germany University Hospital of Bonn Recruiting Bonn, Germany, 53105 Contact: Jurgen Rockstroh, MD +49-228-287-16558 Juergen.Rockstroh@ukb.uni-bonn.de Netherlands Academic Medical Centre, University of Amsterdam Recruiting Amsterdam, Netherlands, 1105 AZ Contact: Marc van der Valk, PhD +31 20 566 9111 m.vandervalk@amc.uva.nl New Zealand Auckland City Hospital Not yet recruiting Auckland, New Zealand, 1142 Contact: Ed Gane, MBChB, MD +64 9 3074949 ext 22920 edgane@adhb.govt.nz Switzerland Bern University Hospital Not yet recruiting Bern, Switzerland, 3010 Contact: Andri Rauch, MD +41 31 632 21 11 Andri.Rauch@insel.ch United Kingdom Royal Free Hospital Recruiting London, United Kingdom, NW3 2QG Contact: Sanjay Bhagani, MBChB +44 20 7794 0500 ext 36285 s.bhagani@nhs.net Chelsea & Westminster Hospital Recruiting London, United Kingdom, SW10 9NH Contact: Mark Nelson, MA, MBBS, FRCP +44 (0)203 315 5601 mark.nelson@chelwest.nhs.uk Collapse <<
NCT03018353	Hepatitis C, Chronic	Phase 4	Enrolling by invitation	June 4, 2018	United States, California ... more >> Jail Health Services San Francisco, California, United States, 94103 Collapse <<
NCT03112044	Lung Transplant Infection ... more >> Hepatitis C Collapse <<	Early Phase 1	Recruiting	December 31, 2018	Canada, Ontario ... more >> University Health Network Toronto General Hospital Recruiting Toronto, Ontario, Canada, M5G 2N2 Contact: Marcelo Cypel, MD MSc FRCSC 416-340-4800 ext 5156 Marcelo.Cypel@uhn.ca Contact: Ilona Bahinskaya, MSc 416-340-4800 ext 4328 Ilona.Bahinskaya@uhnresearch.ca Collapse <<
NCT03222531	-	-	Recruiting	July 1, 2019	United States, Pennsylvania ... more >> UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: Christopher Sciortino, MD 412-647-6636 sciortinocm@upmc.edu Principal Investigator: Christopher Sciortino Collapse <<
NCT02468648	Chronic Hepatitis C	Phase 2	Completed	-	United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse <<
NCT02185794	Hepatitis C Virus Infection	Phase 1	Completed	-	United States, California ... more >> Costa Mesa, California, United States United States, Florida DeLand, Florida, United States Orlando, Florida, United States United States, Missouri Kansas City, Missouri, United States Saint Louis, Missouri, United States United States, New Jersey Berlin, New Jersey, United States Marlton, New Jersey, United States United States, Pennsylvania Philadelphia, Pennsylvania, United States United States, Tennessee Knoxville, Tennessee, United States United States, Texas San Antonio, Texas, United States Puerto Rico San Juan, Puerto Rico Collapse <<
NCT02639247	Hepatitis C Virus Infection	Phase 3	Completed	-	-
NCT02639338	Hepatitis C Virus Infection	Phase 3	Completed	-	-
NCT02639247	-	-	Completed	-	-
NCT03619837	Hepatitis C T... more >>ransplantation Disease Transmission Collapse <<	Phase 4	Recruiting	January 2021	United States, California ... more >> University of California, San Francisco Recruiting San Francisco, California, United States, 94143 Contact: Rae Davis 415-514-3274 rayshawnda.davis@ucsf.edu Contact: Wesley Chan 415-476-5504 wesley.chan@ucsf.edu Principal Investigator: Norah Terrault, MD United States, Colorado University of Colorado Denver Recruiting Aurora, Colorado, United States, 80045 Contact: Sandra Boimbo 303-724-8892 Sandra.Boimbo@ucdenver.edu Principal Investigator: James Burton, MD United States, Georgia Piedmont Research Institute Recruiting Atlanta, Georgia, United States, 30309 Contact: Natasha Morris 404-605-4618 Natasha.Morris@piedmont.org Contact: Bethany.Lane@piedmont.org Lane 404.605.4618 Bethany.Lane@piedmont.org Principal Investigator: Raymond Rubin, MD United States, New York Columbia University Not yet recruiting New York, New York, United States, 10032 Contact: Ashley Rodriguez 212-305-3839 Ar3450@cumc.columbia.edu Contact: Lauren Starks 212-305-3839 Lvs2132@cumc.columbia.edu Principal Investigator: Elizabeth Verna, MD United States, Texas Baylor University Medical Center - Dallas Not yet recruiting Dallas, Texas, United States, 75246 Contact: Sharon Primeaux 214-818-7876 Sharon.Primeaux@BSWHealth.org Principal Investigator: Joanna Bayer,, MD Houston Methodist Hospital Recruiting Houston, Texas, United States, 77030 Contact: Susan Dorman, RN 713-441-6316 sadorman@houstonmethodist.org Contact: Darrel Cleere, RN dwcleere@houstonmethodist.org Principal Investigator: David Victor, MD Collapse <<
NCT02938013	HCV Coinfection ... more >> Liver Disease HIV Collapse <<	Phase 4	Active, not recruiting	May 2019	United States, Maryland ... more >> Johns Hopkins Hospital : The John G. Bartlett Specialty Practice Baltimore, Maryland, United States, 21287 Collapse <<
NCT03492112	Hepatitis C	Phase 4	Not yet recruiting	November 2019	-
NCT02064049	Hepatitis C	Phase 4	Recruiting	December 2019	Australia, New South Wales ... more >> Goulburn Correctional Centre Recruiting Goulburn, New South Wales, Australia, 2580 Contact: Ronella Williams, RN 02 48272292 Ronella.Williams@justicehealth.nsw.gov.au Contact: Kelly Somes, RN 02 48272292 kelly.somes@justicehealth.nsw.gov.au Principal Investigator: Andrew Lloyd, MBBS,FRACP Lithgow Correctional Centre Recruiting Lithgow, New South Wales, Australia, 2790 Contact: Angela Smith, RN 02 6350 2209 Angela.smith@justicehealth.nsw.gov.au Contact: Katherine McQuillan, RN 02 6350 2209 Katherine.McQuillan@justicehealth.nsw.gov.au Principal Investigator: Andrew Lloyd, MBBS FRACP Dillwynia Correctional Centre Recruiting Windsor, New South Wales, Australia, 2756 Contact: Camilla Lobo, RN 024582 2550 camilla.lobo@justiceheatlh.nsw.gov.au Contact: Kelly Somes, RN 024582 2550 camilla.lobo@justiceheatlh.nsw.gov.au Principal Investigator: Andrew Lloyd, MBBS, FRACP Outer Metropolitan Multipurpose Correctional Centre Recruiting Windsor, New South Wales, Australia, 2756 Contact: Carina Burns, RN 0245822391 carina.burns@justicehealth.nsw.gov.au Contact: Kelly Somes, RN 0245822391 kelly.somes@justicehealth.nsw.gov.au Principal Investigator: Andrew Lloyd, MBBS, FRACP Collapse <<
NCT03570112	-	-	Recruiting	September 2020	United States, Ohio ... more >> Lindner Research Center at the Christ hospital Recruiting Cincinnati, Ohio, United States, 45219 Contact: John Cafardi, MD 513-585-1777 john.cafardi@thechristhospital.com Contact: Roxanne Robertson, RN 513-585-1777 roxanne.robertson@thechristhospital.com Collapse <<
NCT03032666	Thalassemia H... more >>epatitis C Collapse <<	Phase 4	Completed	-	Lebanon ... more >> American University of Beirut Medical Center Beirut, Lebanon Collapse <<
NCT03627546	Hepatitis C D... more >>rug Use Collapse <<	Phase 4	Recruiting	July 10, 2021	United States, New York ... more >> Lower East Side Harm Reduction Center Recruiting New York, New York, United States, 10022 Contact: Melinda Smith 347-566-5506 mjs4001@med.cornell.edu; Sub-Investigator: Benjamin Eckhardt, MD Sub-Investigator: Shashi Kapadia Collapse <<
NCT02639338	-	-	Completed	-	-
NCT01909804	Hepatitis C	Phase 2	Completed	-	-
NCT03086044	Hepatitis C A... more >>waiting Organ Transplant Collapse <<	Phase 4	Recruiting	December 2018	United States, Massachusetts ... more >> Brigham and Women's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Ann Woolley, MD 617-525-8418 awoolley@partners.org Collapse <<
NCT03235154	Hepatitis C, Chronic ... more >> Hepatitis C Opiate Dependence Collapse <<	Phase 4	Recruiting	January 2020	United States, Massachusetts ... more >> Cambridge Health Alliance Outpatient Addiction Services Recruiting Somerville, Massachusetts, United States, 02143 Contact: Zev Schuman-Olivier, MD Collapse <<
NCT03549312	HIV-1-infection ... more >> Hepatitis C, Chronic Intravenous Drug Usage Methadone Dependence Opioid Dependence Drug Abuse Bone Diseases, Metabolic HIV/AIDS Co-infection Collapse <<	Phase 4	Recruiting	June 30, 2019	Canada, Saskatchewan ... more >> Saskatchewan Health Authority Recruiting Regina, Saskatchewan, Canada, S4P 0W5 Contact: Alexander Wong, MD 306-766-3915 alexander.wong@usask.ca Contact: Dennaye Fuchs, RN 306-766-4521 dennaye.fuchs@saskhealthauthority.ca Principal Investigator: Alexander Wong, MD Sub-Investigator: Stuart Skinner, MD Sub-Investigator: Kumudhini Karunakaran, MD Collapse <<
NCT01858766	Hepatitis C	Phase 2	Completed	-	-
NCT01909804	-	-	Completed	-	-
NCT02378961	Hepatitis C Virus Infection	Phase 2	Completed	-	-
NCT02378961	-	-	Completed	-	-
NCT02533427	HCV Infection	Phase 1	Completed	-	New Zealand ... more >> Christchurch, New Zealand Collapse <<
NCT02536313	Hepatitis C Virus Infection	Phase 2	Completed	-	United States, Texas ... more >> The Texas Liver Institute San Antonio, Texas, United States, 78215 Collapse <<
NCT02378935	-	-	Completed	-	-
NCT03512210	Hepatitis C H... more >>IV-1-infection Liver Diseases Collapse <<	Phase 4	Recruiting	April 12, 2022	United States, Alabama ... more >> 31788 Alabama CRS Recruiting Birmingham, Alabama, United States, 35294 Contact: Pamela Cunningham, RN, BSN, MPH 205-996-2373 pamelacunningham@uabmc.edu Principal Investigator: Michael Saag, MD United States, California University of Southern California (1201) Recruiting Los Angeles, California, United States, 90033-1079 Contact: Luis M Mendez 323-343-8283 lmendez@usc.edu Principal Investigator: Fred Sattler, MD UCLA CARE Center CRS (601) Recruiting Los Angeles, California, United States, 90095 Contact: Arezou Akha 310-557-3798 asadighi@mednet.ucla.edudu Principal Investigator: Raphael Landovitz, MD Ucsd, Avrc Crs (701) Recruiting San Diego, California, United States, 92103 Contact: Jill Kunkel 619-543-3094 jkunkel@ucsd.edu Principal Investigator: Constance A. Benson, MD Ucsf Aids Crs (801) Recruiting San Francisco, California, United States, 94110 Contact: Jay Dwyer, RN, ACRN 415-476-4082 ext 353 jdwyer@php.ucsf.edu Principal Investigator: Diane V. Havlir, MD United States, Colorado University of Colorado Hospital CRS (6101) Recruiting Aurora, Colorado, United States, 80045 Contact: Suzanne G Fiorillo, MSPH 303-724-5931 suzanne.fiorillo@ucdenver.edu Principal Investigator: Thomas B Campbell, MD United States, Georgia The Ponce de Leon Center CRS Recruiting Atlanta, Georgia, United States, 30308 Contact: Ericka Patrick 404-616-6313 erpatri@emory.edu Principal Investigator: Carlos Del Rio United States, Illinois Rush Univ. Med. Ctr. ACTG CRS (2702) Recruiting Chicago, Illinois, United States, 60612 Contact: Antoinette Lewis 312-942-2050 antoinette_lewis@rush.edu Principal Investigator: Beverly E Sha, MD United States, Maryland 201 Johns Hopkins University CRS Recruiting Baltimore, Maryland, United States, 21205 Contact: Ilene Wiggins, RN 410-955-8571 iwiggin1@jhmi.edu Principal Investigator: Yukari C Manabe, MD United States, Massachusetts 101 Massachusetts General Hospital (MGH) CRS Recruiting Boston, Massachusetts, United States, 02114 Contact: Teri Flynn, RN, ANP, MSN 617-724-0072 tflynn@partners.org Principal Investigator: Rajesh Gandhi, MD 107 Brigham and Women's Hosp. ACTG CRS Recruiting Boston, Massachusetts, United States, 02115 Contact: Cheryl Keenan, RN 617-732-5635 Ckennan@BWH.Harvard.edu Contact 617-732-5635 Ckennan@BWH.Harvard.edu Principal Investigator: Paul E. Sax, MD United States, Missouri Washington U CRS (2101) Recruiting Saint Louis, Missouri, United States, 63110 Contact: Michael Klebert, RN,C, PhD, ANP 1-314-747-1098 mklebert@im.wustl.edu Principal Investigator: Rachel Presti, MD, PhD United States, New York 7803 Weill Cornell Upton CRS Recruiting New York, New York, United States, 10065 Contact: Rebecca Fry, MSN, FNP 212-746-4166 ref2007@med.cornell.edu Principal Investigator: Marshall J. Glesby, MD United States, North Carolina Greensboro CRS (3203) Recruiting Greensboro, North Carolina, United States, 27401 Contact: Kim Epperson, RN, BSN, CCRC 336-832-7888 kim.epperson@mosecone.com Principal Investigator: Cornelius Van Dam, MD United States, Ohio Univ. of Cincinnati CRS (2401) Recruiting Cincinnati, Ohio, United States, 45267 Contact: Sharon Kohrs, RN, BSN 513-584-6383 kohrssd@ucmail.uc.edu Principal Investigator: Carl Fichtenbaum, MD Case CRS (2501) Recruiting Cleveland, Ohio, United States, 44106 Contact: Jane Baum, RN 216-844-2546 baum.jane@clevelandactu.org Principal Investigator: Benigno Rodriguez, MD The Ohio State Univ. AIDS CRS (2301) Recruiting Columbus, Ohio, United States, 43210 Contact: Kathy Watson, RN 614-293-5856 kathy.watson@osumc.edu Principal Investigator: Susan Koletar, MD United States, Pennsylvania Hosp. of the Univ. of Pennsylvania CRS (6201) Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Eileen Donaghy, BSN, CRNP 215-349-8092 eileen.donaghy2@uphs.upenn.edu Principal Investigator: Pablo Tebas, MD Pittsburgh CRS (1001) Recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: Patricia Peters 412-383-1675 pep1@pitt.edu Principal Investigator: Sharon Riddler, MD, MPH United States, Texas Houston AIDS Research Team CRS (31473) Recruiting Houston, Texas, United States, 77030 Contact: Maria Martinez, BS 713-500-6718 maria.l.martinez@uth.tmc.edu Principal Investigator: Roberto Arduino, MD Puerto Rico Puerto Rico-AIDS CRS (5401) Recruiting San Juan, Puerto Rico, 00931 Contact: Sylvia Davila, BS, MS (787) 767-9192 sylvia.davila@upr.edu Principal Investigator: Jorge Santana, MD Collapse <<
NCT02220998	Hepatitis C Virus Infection	Phase 3	Completed	-	-
NCT02536313	-	-	Completed	-	-
NCT02300103	-	-	Completed	-	-
NCT02378935	Hepatitis C Virus Infection	Phase 2	Completed	-	-
NCT02300103	Hepatitis C Virus Infection	Phase 2	Completed	-	-
NCT03250910	Hepatitis C Virus Infection, R... more >>esponse to Therapy of Human Immunodeficiency Virus Collapse <<	Phase 4	Completed	-	Taiwan ... more >> National Taiwan University Hospital, Yun-Lin Branch Douliu, Taiwan National Taiwan University Hospital Taipei, Taiwan Collapse <<
NCT02480712	Hepatitis C Virus Infection	Phase 3	Completed	-	United States, Alabama ... more >> Birmingham, Alabama, United States United States, California Los Angeles, California, United States San Diego, California, United States San Francisco, California, United States Torrance, California, United States United States, Georgia Atlanta, Georgia, United States United States, Illinois Chicago, Illinois, United States United States, Maryland Baltimore, Maryland, United States Lutherville, Maryland, United States United States, Massachusetts Boston, Massachusetts, United States United States, New York Bronx, New York, United States New York, New York, United States United States, North Carolina Durham, North Carolina, United States United States, Ohio Cincinnati, Ohio, United States United States, Virginia Richmond, Virginia, United States Collapse <<
NCT02201953	Hepatitis C Virus Infection	Phase 3	Completed	-	-
NCT02480712	-	-	Completed	-	-
NCT02671500	Hepatitis C Virus Infection	Phase 3	Completed	-	-
NCT02996682	Hepatitis C Virus Infection	Phase 3	Completed	-	Japan ... more >> Shimonoseki, Yamaguchi, Japan Bunkyo, Japan Chiba, Japan Chuo, Japan Ehime, Japan Fukui, Japan Fukuyama-shi, Japan Hiroshima, Japan Ibaraki, Japan Ichikawa, Japan Iizuka City, Japan Iruma, Japan Izunokuni, Japan Kashibara, Japan Kofu, Japan Kumamoto-shi, Japan Kurume, Japan Kyoto, Japan Miyazaki-shi, Japan Morioka, Japan Musashino, Japan Nagoya, Japan Nishinomiya, Japan Okayama, Japan Omura, Japan Osaka, Japan Sapporo, Japan Sendai, Japan Shimotsuga-gun, Japan Suita, Japan Takamatsu, Japan Ube, Japan Yamagata, Japan Collapse <<
NCT02201901	Hepatitis C Virus Infection	Phase 3	Completed	-	-
NCT02201953	-	-	Completed	-	-
NCT02201940	-	-	Completed	-	-
NCT02201901	-	-	Completed	-	-
NCT03501550	Chronic Hepatitis C	Phase 2	Active, not recruiting	April 30, 2019	United States, Maryland ... more >> Institute of Human Virology University of Maryland Baltimore, Maryland, United States, 21201 Collapse <<
NCT02346721	-	-	Completed	-	-
NCT02822794	Hepatitis C Virus Infection	Phase 3	Completed	-	Japan ... more >> Ehime, Japan Hiroshima, Japan Ichikawa-shi, Japan Iruma-gun, Japan Kashihara, Japan Kurume-shi, Japan Kyoto, Japan Maebashi, Japan Musashino-shi, Japan Nagoya, Japan Nishinomiya, Japan Ogaki City, Japan Okayama, Japan Omura, Japan Sapporo, Japan Suita, Japan Takamatsu-shi, Japan Yamagata, Japan Collapse <<
NCT02220998	-	-	Completed	-	-
NCT02201940	Hepatitis C Virus Infection	Phase 3	Completed	-	-
NCT02346721	Hepatitis C Virus Infection	Phase 3	Completed	-	-
NCT02607735	Hepatitis C	Phase 3	Completed	-	-
NCT02607735	-	-	Completed	-	-
NCT02822794	-	-	Completed	-	-
NCT02607800	Hepatitis C	Phase 3	Completed	-	-
NCT02781558	Hepatitis C Virus Infection	Phase 2	Completed	-	Spain ... more >> Hospital Universitario Marques de Valdecilla Santander, Cantabria, Spain Hospital Universitario Fundacion Alcorcon Alcorcon, Spain Hospital General Universitario De Alicante Alicante, Spain Complejo Hospitalario Torrecárdenas Almeria, Spain Hospital Germans Trias i Pujol Badalona, Spain Hospital Universitario Valle Hebron Barcelona, Spain, 8035 Hospital Clínic de Barcelona Barcelona, Spain Hospital del Mar Barcelona, Spain Hospital Universitari de Bellvitge Barcelona, Spain Servei de d'Aparell Digestiu Corporació Sanitària Parc Taulí Barcelona, Spain Reina Sofía University Hospital Cordoba, Spain Hospital Universitario de A Coruña Coruna, Spain Hospital Puerta De Hierro Majadahonda Madrid, Spain Hospital Ramón y Cajal Madrid, Spain Hospital Universitario La Paz Madrid, Spain Hospital Universitario Virgen de la Victoria Malaga, Spain Hospital Universitario Virgen De La Arrixaca Murcia, Spain Hospital Universitario Central de asturias Oviedo, Spain Complexo Hospitalario Universitario de Montecelo Pontevedra, Spain Hospital Universitario Donostia San Sebastian, Spain Hospital Univ. NuestraSeñora Candelaria Santa Cruz de Tenerife, Spain Hospital de Valme Sevilla, Spain Hospital Universitario Virgen Del Rocio Sevilla, Spain Hospital Clinico Universitario Valencia, Spain Hospital General Valencia Valencia, Spain La Fe Hospital Valencia, Spain Hospital Universitario Alvaro Cunqueiro Vigo, Spain Hospital Clinico Universitario Zaragoza, Spain Collapse <<
NCT02607800	-	-	Completed	-	-
NCT02722837	Hepatitis C Virus Infection	Phase 3	Completed	-	Russian Federation ... more >> Krasnoyarsk Regional Center of AIDS Prevention Krasnoyarsk, Russian Federation Central Research Institute of Epidemiology Moscow, Russian Federation Central Scientific-Research Institute of Epidemiology Moscow, Russian Federation City Clinical Hospital # 24 Moscow, Russian Federation First Moscow Medical University I.M.Sechenov. Moscow, Russian Federation First Moscow State Medical University I.M. Sechenov Moscow, Russian Federation Limited Liability Company "Clinic Tour" Moscow, Russian Federation Scientific Research Institute of Nutrition Moscow, Russian Federation Sklifosovsky Scientific Research Institution of Emergency Care Moscow, Russian Federation Center for Prevention and Control of AIDS and Infectious Diseases Saint Petersburg, Russian Federation Kirov Medical Military Academy Saint Petersburg, Russian Federation North-Western State Medical University named after I.I. Mechnikov Saint Petersburg, Russian Federation LLC Medical Company "Hepatolog" Samara, Russian Federation Sweden Sahlgrenska Universitetsjukhuset Göteborg, Sweden Karolinska University Hospital Huddinge Stockholm, Sweden Collapse <<
NCT02722837	-	-	Completed	-	-
NCT03313414	Hepatitis C	Phase 4	Not yet recruiting	July 1, 2022	United States, Massachusetts ... more >> Massachusetts General Hospital Not yet recruiting Boston, Massachusetts, United States, 02114 Contact: Jenna L Gustafson, MSc 617-724-3836 JLGustafson@partners.org Principal Investigator: Raymond T Chung, MD Collapse <<
NCT03036852	Chronic Hepatitis c	Phase 2	Completed	-	Australia, South Australia ... more >> Royal Adelaide Hospital Adelaide, South Australia, Australia, 5000 Canada, Alberta Kaye Edmonton Clinic Edmonton, Alberta, Canada Canada, British Columbia Gordon and Leslie Diamond Health Care Center, Vancouver General Hospital, UBC Division of Gastroenterology Vancouver, British Columbia, Canada, BC V5Z 1M9 Canada, Ontario William Osler Health System- Brampton Civic Hospital Brampton, Ontario, Canada Hamilton Health Sciences - McMaster University Medical Centre Site Hamilton, Ontario, Canada, ON L8V Ottawa Hospital Research Institute Ottawa, Ontario, Canada, K1H 8L6 Canada, Quebec Centre de Recherche du Centre Hospitalier de l'Universite de Montreal (CRCHUM) Montréal, Quebec, Canada, H2X 3J4 Israel Shaare Zedek Medical Center Jerusalem, Israel, 9103102 The Chaim Sheba Medical Centre Ramat Gan, Israel, 52173 Tel Aviv Sourasky Medical Center Tel Aviv, Israel, 64239 New Zealand Auckland City Hospital Grafton, Auckland, New Zealand, 1010 Spain Hospital Universitario Fundación Alcorcón Alcorcón, Madrid, Spain, 28922 Hospital Universitari Vall d'Hebron Barcelona, Spain, 08035 Hospital Universitario Puerta de Hierro - Majadahonda Majadahonda, Spain, 28222 Hospital Universitario Virgen del Rocío Sevilla, Spain, 41013 United Kingdom Gartnavel General Hospital Glasgow, United Kingdom, G12 0YN Barts Health NHS Trust London, United Kingdom, E1 1BB King's College Hospital London, United Kingdom, SE5 9RS Chelsea and Westminster Hospital London, United Kingdom, SW10 9NH Imperial College Healthcare NHS Trust London, United Kingdom, W2 1NY Nottingham University Hospitals NHS Trust Nottingham, United Kingdom, NG5 1PB Derriford Hospital Plymouth, United Kingdom, PL6 8DH Collapse <<
NCT01740791	Chronic Hepatitis C Virus	Phase 1	Completed	-	United States, California ... more >> West Coast Clinical Trials, LLC Costa Mesa, California, United States, 92626 United States, Florida Avail Clinical Research, LLC Deland, Florida, United States, 32720 Orlando Clinical Research Center Orlando, Florida, United States, 32809 United States, Missouri Kansas City Gastroenterology and Hepatology Kansas City, Missouri, United States, 64131 United States, New Jersey CRI Worldwide, LLC Marlton, New Jersey, United States, 08053 United States, Pennsylvania CRI Worldwide, LLC Philadelphia, Pennsylvania, United States, 19139 United States, Tennessee New Orleans Center for Clinical Research-Knoxville Knoxville, Tennessee, United States, 37920 United States, Texas Alamo Medical Research San Antonio, Texas, United States, 78215 United States, Washington Charles River Clinical Services Northwest, Inc. Tacoma, Washington, United States, 98418 Puerto Rico Fundacion De Investigacion De Diego San Juan, Puerto Rico, 00927 Collapse <<
NCT02994056	Hepatitis C Virus Infection	Phase 2	Active, not recruiting	December 2018	United States, Florida ... more >> Tampa General Medical Group Tampa, Florida, United States, 33606 United States, Illinois Northwestern Memorial Hospital; Clinical Research Unit Chicago, Illinois, United States, 60611 United States, Maryland Digestive Disease Associates, PA Catonsville, Maryland, United States, 21228 United States, Mississippi Southern Therapy and Advanced Research LLC Jackson, Mississippi, United States, 39216 United States, New York Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 United States, Pennsylvania Hospital of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 United States, Texas American Research Corporation at Texas Liver Institute San Antonio, Texas, United States, 78215 United States, Utah Intermountain Liver Disease and Transplant Center Murray, Utah, United States, 84107 United States, Virginia Bon Secours St. Mary's Hospital of Richmond, Inc. d/b/a Bon Secours Liver Institute of Virginia Richmond, Virginia, United States, 23226 United States, Washington University of Washington/ Harborview Medical Center Seattle, Washington, United States, 98105 France Hopital Henri Mondor Créteil, France, 94010 Hopital Paul Brousse Villejuif, France, 94800 Collapse <<
NCT03074331	Hepatitis C Virus Infection	Phase 3	Completed	-	India ... more >> Institute of Liver and Biliary Sciences New Delhi, Delhi, India, 110070 Seth GS Medical College and KEM hospital Mumbai, Maharashtra, India, 400012 Government Medical College & Super Speciality Hospital Nagpur, Maharashtra, India, 440003 All India Institute of Medical Sciences Delhi, New Delhi, India, 110029 Global Hospital-Super Speciality & Transpant Centre (A Unite of Centre for Digestive & Kidney Diseases (India) PVT LTD. Mumbai, Parel, India, 400012 Post Graduate Institute of Medical Education and Resesarch (PGIMER) Chandigarh, Punjab, India, 160012 YRG Care Chennai, Tamil Nadu, India, 600010 VGM Hospital - Institute of Gastroenterology Coimbatore, Tamilnadu, India, 641005 Gandhi Hospital Secunderabad, Telangana, India, 500003 Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow, Uttar Pradesh, India, 226014 Department of Hepatology, School of Digestive and Liver Diseases Kolkata, West Bengal, India, 700020 Institute of Digestive and Liver Disease Guwahati, India, 781006 Global Hospitals Hyderabad, India, 500004 Lakeshore Hospital Kochi, India, 682040 Dayanand Medical College & Hospital Ludhiana, India, 141001 Nirmal Hospital Surat, India, 395002 Collapse <<
NCT02781558	-	-	Completed	-	-
NCT02728206	Hepatitis C Virus Infection	Phase 2	Completed	-	New Zealand ... more >> Auckland, New Zealand Collapse <<
NCT02781571	-	-	Completed	-	-
NCT01817985	Chronic Hepatitis C	Phase 1	Completed	-	United States, Florida ... more >> Investigational Site Miami, Florida, United States, 33014 Investigational Site Miami, Florida, United States, 33169 Investigational Site Orlando, Florida, United States, 32806 Investigational Site Orlando, Florida, United States, 32809 United States, Texas Investigational Site San Antonio, Texas, United States, 78215 Puerto Rico Investigational Site San Juan, Puerto Rico, 00927 Collapse <<
NCT02002767	Hepatitis C Virus	Phase 1	Completed	-	United States, Florida ... more >> Miami, Florida, United States, 33014 Orlando, Florida, United States, 32809 United States, Minnesota St. Paul, Minnesota, United States, 55114 United States, Texas San Antonio, Texas, United States, 78215 New Zealand Christchurch, New Zealand, 08011 Collapse <<
NCT03118843	Hepatitis C Virus Infection	Phase 3	Completed	-	-
NCT02336139	Hepatitis C	Phase 2	Active, not recruiting	December 2018	Australia, New South Wales ... more >> The Kirby Institute Sydney, New South Wales, Australia, 2052 Collapse <<
NCT03022981	Hepatitis C Virus Infection	Phase 2	Recruiting	March 2020	-
NCT03513393	Hepatitis C S... more >>wallowing Disorder Collapse <<	Phase 1	Not yet recruiting	December 1, 2018	Netherlands ... more >> Radboud university medical Center Not yet recruiting Nijmegen, Gelderland, Netherlands, 6525 GA Contact: David M Burger, prof. dr. +31243617744 david.burger@radboudumc.nl Principal Investigator: David M Burger, prof. dr. Collapse <<
NCT02781571	Hepatitis C Virus Infection	Phase 2	Completed	-	Spain ... more >> Hospital Clínic de Barcelona Barcelona, Spain Hospital Universitari Vall d'Hebron Barcelona, Spain Reina Sofía University Hospital Córdoba, Spain Hospital General Universitario Gregorio Maranon Madrid, Spain Hospital Ramón Y Cajal Madrid, Spain Hospital Universitario Virgen del Rocío Sevilla, Spain La Fe Hospital Valencia, Spain Hospital Clinico Zaragoza Zaragoza, Spain Switzerland Universität Bern Bern, Switzerland University Hospital Zurich Zürich, Switzerland United Kingdom Cambridge University Hospitals NHS Foundation Trust Cambridge, United Kingdom Royal Infirmary of Edinburgh Edinburgh, United Kingdom St James University Hospital Leeds, United Kingdom Kings College Hospital London, United Kingdom Royal Free Hampstead NHS Trust London, United Kingdom Collapse <<
NCT02836925	Indolent B-cell Lymphoma ... more >> Hepatitis C Collapse <<	Phase 2	Recruiting	May 2022	Italy ... more >> A.O. Spedali Civili Recruiting Brescia, BS, Italy, 25100 Contact: Marina Motta, MD +39 0303996269 marina.motta@spedalicivili.brescia.it Principal Investigator: Marina Motta, MD Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Not yet recruiting Milano, MI, Italy, 20122 Contact: Luca Baldini, MD 0039 02 55033334 luca.baldini@unimi.it Principal Investigator: Luca Baldini Irccs Centro Di Riferimento Oncologico (Cro) Recruiting Aviano, Pordenone, Italy, 33801 Contact: Michele Spina mspina@cro.it Principal Investigator: Michele Spina, MD Ospedale San Bortolo Recruiting Vicenza, VI, Italy, 36100 Contact: Carlo Visco, MD +39 0444-753626/3518 carlovisco@hotmail.com;silvia.finotto@gmail.com Principal Investigator: Carlo Visco, MD Ospedale Policlinico G.B. Rossi (Borgo Roma) Di Verona Not yet recruiting Verona, VR, Italy, 37126 Principal Investigator: Dino Veneri, MD A.O. Universitaria Careggi Di Firenze Not yet recruiting Firenze, Italy, 50139 Contact: Luigi Rigacci Contact luigi.rigacci@unifi.it Principal Investigator: Luigi Rigacci, MD Sc Ematologia Ao Niguarda Ca' Granda Not yet recruiting Milano, Italy, 20162 Contact: Alessandra Tedeschi alessandra.tedeschi@ospedaleniguarda.it Ematologia e Trapianto IRCCS, Istituto Nazionale dei Tumori Recruiting Milano, Italy Principal Investigator: Anna Dodero, MD Ospedale San Raffaele Ematologia Recruiting Milano, Italy Principal Investigator: Andrés Ferreris, MD IRCCS Fondazione Pascale Not yet recruiting Napoli, Italy, 80131 Principal Investigator: Antonello Pinto, MD U.O. Ematologia AO di Padova Recruiting Padova, Italy Contact: Francesco Piazza francesco.piazza@unipd.it Principal Investigator: Francesco Piazza Policlinico P.Giaccone Not yet recruiting Palermo, Italy Principal Investigator: Emilio Iannitto, MD A.O. Universitaria Di Parma Recruiting Parma, Italy, 43126 Contact fre@ao.pr.it Principal Investigator: Francesca Re, MD Ematologia Policlinico San Matteo Recruiting Pavia, Italy, 27100 Contact: Luca Arcaini, M.D. 00390382503595 luca.arcaini@unipv.it Principal Investigator: Luca Arcaini, M.D. Ospedale Civile Piacenza Recruiting Piacenza, Italy Contact: Daniele Vallisa, MD d.vallisa@ausl.pc.it Principal Investigator: Daniele Vallisa Ematologia - Policlinico Umberto I Università Sapienza Recruiting Roma, Italy Contact: Alessandro Pulsoni pulsoni@bce.uniroma1.it Principal Investigator: Alessandro Pulsoni Dipartimento di Oncologia Medica ed Ematologia, Istituto Humanitas Recruiting Rozzano, Italy Contact: Armando Santoro, MD Principal Investigator: Armando Santoro, MD AOU Città della Salute e della Scienza di Torino Recruiting Torino, Italy, 10126 Contact: Lorella Orsucci, MD lorsucci@cittadellasalute.to.it Principal Investigator: Lorella Orsucci, MD A.O. Universitaria S. Maria Della Misericordia Di Udine Not yet recruiting Udine, Italy, 33100 Principal Investigator: Francesco Zaja, MD Ospedale di Circolo e Fondazione Macchi Recruiting Varese, Italy Principal Investigator: Michele Merli, MD Collapse <<
NCT02745535	Chronic Hepatitis C	Phase 2	Completed	-	United States, Maryland ... more >> Institute of Human Virology Baltimore, Maryland, United States, 21201 Collapse <<
NCT03389061	HCV	Phase 4	Recruiting	December 1, 2018	Germany ... more >> University of Bonn, Germany Not yet recruiting Bonn, Germany Contact: Juergen Rockstroh Netherlands Jeroen Bosch Hospital Not yet recruiting 's-Hertogenbosch, Netherlands Contact: Bram Schaap Sub-Investigator: Jeroen Derijks Radboud university medical center Department of GI tract Recruiting Nijmegen, Netherlands Contact: Joost Drenth Collapse <<
NCT03057847	Hepatitis C, Chronic ... more >> Opioid-use Disorder Collapse <<	Phase 4	Recruiting	December 2019	United States, Pennsylvania ... more >> Magee Womens Hospital of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: Wallita Abdullah 412-641-6377 abdullahw@upmc.edu Contact: Hollis Laird 412-641-2248 lairdh2@mwri.magee.edu Collapse <<

Velpatasvir/维帕他韦 Catalog No. CSN17357

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