CAS No.: 1392136-43-4
Verdinexor Catalog No. CSN17781
Synonyms: KPT-335
Verdinexor is an orally bioavailable selective inhibitor of nuclear export (SINE), inhibits nuclear export protein Exportin 1 (XPO1/CRM1) against canine tumor cell lines and also reduce influenza virus replication in vitro and in vivo.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
动物研究 剂量 Mice[3]: min = 10 mg/kg (p.o.), max = 50 mg/kg (p.o.); 5 mg/kg(i.v.)
给药途径 p.o.
动物药代数据 Animal Mice[3] Dogs[1] Dose 10 mg/kg 1.46 ± 0.0542 mg/kg Administration p.o. p.o. Cmax 1660 ng/ml 253 ± 88.3 ng/ml T1/2 4.88 h 3.88 ± 1.47 h AUC0→∞ 1810 ± 216 h·ng/mL F 0.435 AUClast 10300 h·ng/ml Tmax 1 h 3.83 ± 2.71 h AUC∞ 10800 h· g/ml AUC0→last 1760 ± 223 h·ng/mL - 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02431364 Healthy Phase 1 Completed - Australia, Victoria ... more >> Nucleus Network Melbourne, Victoria, Australia Collapse << - 参考文献
- [1] London CA, Bernabe LF, et al. Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: results of a phase I study. PLoS One. 2014 Feb 4;9(2):e87585.
- [2] Jorquera PA, Mathew C, et al. Verdinexor (KPT-335), a Selective Inhibitor of Nuclear Export, Reduces Respiratory Syncytial Virus Replication In Vitro. J Virol. 2019 Feb 5;93(4). pii: e01684-18.
- [3] Perwitasari O, Johnson S, et al. Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo. J Virol. 2014 Sep 1;88(17):10228-43.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1392136-43-4 | 储存条件 |
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| 分子式 | C18H12F6N6O | 运输 | 蓝冰 | |||||||||||||
| 分子量 | 442.32 | 别名 | KPT-335 | |||||||||||||
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动物实验配方 |
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