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CAS No.: 3681-93-4

Vitexin/牡荆素 Catalog No. CSN12211

Synonyms: Orientoside;Apigenin 8-C-glucoside;牡荆素

Vitexin exhibits inhibition of carbohydrate hydrolase with IC50 of 244 μM and shows antioxidant activity in DPPH bleaching assay (IC50 = 24.2 μM). It is an apigenin flavone c-glycosidea isolated and purified from the seeds of Vitex trifolia L. with antinociceptive, antimyeloperoxidase, and anti-inflammatory activities.

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技术信息

生物活性

描述Vitexin exhibits inhibition of carbohydrate hydrolase with IC50 of 244 μM and shows antioxidant activity in DPPH bleaching assay (IC50 = 92.5 μM [0.4 μg/mL])^[3]. It is an apigenin flavone c-glycosidea isolated and purified from the seeds of Vitex trifolia L. with antinociceptive, antimyeloperoxidase, and anti-inflammatory activities^[4]. The MCAO (middle cerebral artery occlusion)-induced brain infarction was obviously decreased by vitexin. Vitexin suppressed the autophagy dysfunction to attenuate MCAO-induced cerebral ischemic stroke via mTOR/Ulk1 pathway^[5]. Vitexin inhibited growth and induced apoptosis of ACHN and OS-RC-2 cells in a dose-dependent manner, and promoted excessive autophagy by reducing p62 levels and increasing Beclin1 and LC3II levels^[6]. The systemic administration of vitexin (1.25; 2.5 and 5 mg/kg; i.p.) exhibited selective protection against chemically-induced seizures. The higher dose of vitexin protected 100% of animals against the tonic-clonic seizures triggered by GABA antagonists. The results from open-field, elevated plus-maze, and light-dark box tests indicated the anxiolytic properties of vitexin at similar range of doses described for the anticonvulsant action screening^[7]. Vitexin protected melanocytes from oxidative stress by activating MAPK-Nrf2/ARE signaling pathway^[8]. Vitexin was not cytotoxic (IC50 > 200 µg/ml) in RAW 264.7 and at all doses tested it effectively reduced leukocyte migration in vivo, particularly neutrophils in the peritoneal lavage, independently of the inflammatory stimulus used. It also reduced TNF-α, IL-1β and NO releases in the peritoneal cavity of LPS-challenged mice. Vitexin had low cytotoxicity and was able to reduce the releases of TNF-α, IL-1β, NO, PGE2 and increase in IL-10 release by LPS activated RAW 264.7 cells. Vitexin was also able to regulate transcriptional factors for pro-inflammatory mediators, reducing the expression of p-p38, p-ERK1/2 and p-JNK in LPS-elicited cells^[9].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01647984	Ventricular and Atrial Extrasy... more >>toles Collapse <<	Phase 4	Completed	-	Italy ... more >> Ambulatorio Ipertensione e Unità Coronarica Federico II University Naples, Italy, 80131 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3128 mL
- 11.5640 mL
- 23.1279 mL
- 5 mM
- 0.4626 mL
- 2.3128 mL
- 4.6256 mL
- 10 mM
- 0.2313 mL
- 1.1564 mL
- 2.3128 mL

技术信息

CAS号

3681-93-4

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H20O10

运输

蓝冰

分子量

432.38

别名

Orientoside;Apigenin 8-C-glucoside;牡荆素

溶解度

DMSO	60.0 mg/mL (138.8 mM) warming

动物实验配方

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