CAS No.: 508233-74-7
Vortioxetine/沃替西汀 Catalog No. CSN12928
Synonyms: Lu AA 21004;AA-21004;Brintellix
Vortioxetine is a 5-HT3, 5-HT1D, and 5-HT7 antagonist, a 5-HT1A agonist, and a 5-HT1B partial agonist.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 SERT
IC50:1.6nM5-HT Receptor 1A
IC50:15nM5-HT Receptor 7
IC50:19nM5-HT Receptor 3A
IC50:3.7nM5-HT Receptor 1B
IC50:33nM- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02191358 - - Completed - United States, California ... more >> Dr. Michael Dao Garden Grove, California, United States, 92844 United States, Colorado Kaiser Permanente Colorado Denver, Colorado, United States, 80011 United States, Kentucky Gill Heart Institute Lexington, Kentucky, United States, 40508 United States, Maryland IRC Clinics Towson, Maryland, United States, 21204 United States, Massachusetts Internal Medicine & Cardiology Associates Fall River, Massachusetts, United States, 02720 Prima CARE Fall River, Massachusetts, United States, 02720 United States, Virginia Carilion Clinic Christiansburg, Virginia, United States, 24073 Collapse << NCT02883660 - - Completed - United States, Pennsylvania ... more >> Thomas Jefferson University Philadelphia, Pennsylvania, United States, 19107 Collapse << NCT02855229 - - Recruiting March 2020 United States, Massachusetts ... more >> McLean Hospital Recruiting Belmont, Massachusetts, United States, 02478 Contact: David J Crowley, ALM 800-333-0338 ext 4432 neurolab@mclean.harvard.edu Principal Investigator: Diego A Pizzagalli, PhD Collapse << - 更多
- 参考文献
- [1] Mork A, Pehrson A, et al. Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder. J Pharmacol Exp Ther. 2012 Mar;340(3):666-75.
- [2] Bang-Andersen B, Ruhland T, et al. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl] piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21
- [3] Bang-Andersen B, Ruhland T, Jørgensen M, Smith G, Frederiksen K, Jensen KG, Zhong H, Nielsen SM, Hogg S, Mørk A, Stensbøl TB. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21.
- [4] Mørk A, Pehrson A, Brennum LT, Nielsen SM, Zhong H, Lassen AB, Miller S, Westrich L, Boyle NJ, Sánchez C, Fischer CW, Liebenberg N, Wegener G, Bundgaard C, Hogg S, Bang-Andersen B, Stensbøl TB. Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder. J Pharmacol Exp Ther. 2012 Mar;340(3):666-75.
- [5] Guilloux JP, Mendez-David I, Pehrson A, Guiard BP, Repérant C, Orvoën S, Gardier AM, Hen R, Ebert B, Miller S, Sanchez C, David DJ. Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice. Neuropharmacology. 2013 Oct;73:147-59.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 508233-74-7 | 储存条件 |
|
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| 分子式 | C18H22N2S | 运输 | 蓝冰 | |||||||
| 分子量 | 298.45 | 别名 | Lu AA 21004;AA-21004;Brintellix;沃替西汀 | |||||||
| 溶解度 |
|
动物实验配方 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT02191358 | - | - | Completed | - | United States, California ... more >> Dr. Michael Dao Garden Grove, California, United States, 92844 United States, Colorado Kaiser Permanente Colorado Denver, Colorado, United States, 80011 United States, Kentucky Gill Heart Institute Lexington, Kentucky, United States, 40508 United States, Maryland IRC Clinics Towson, Maryland, United States, 21204 United States, Massachusetts Internal Medicine & Cardiology Associates Fall River, Massachusetts, United States, 02720 Prima CARE Fall River, Massachusetts, United States, 02720 United States, Virginia Carilion Clinic Christiansburg, Virginia, United States, 24073 Collapse << |
| NCT02883660 | - | - | Completed | - | United States, Pennsylvania ... more >> Thomas Jefferson University Philadelphia, Pennsylvania, United States, 19107 Collapse << |
| NCT02855229 | - | - | Recruiting | March 2020 | United States, Massachusetts ... more >> McLean Hospital Recruiting Belmont, Massachusetts, United States, 02478 Contact: David J Crowley, ALM 800-333-0338 ext 4432 neurolab@mclean.harvard.edu Principal Investigator: Diego A Pizzagalli, PhD Collapse << |
| NCT03485274 | Cannabis Use Disorder ... more >> Depressive State Anxiety State Depression Anxiety Disorders Pharmacotherapy Collapse << | Phase 2 Phase 3 | Recruiting | September 30, 2019 | Hong Kong ... more >> Queen Mary Hospital Recruiting Hong Kong, Hong Kong, 000000 Contact: Albert KK Chung 2255 3067 chungkka@hku.hk Collapse << |
| NCT00839423 | Major Depressive Disorder | Phase 2 | Completed | - | - |
| NCT00839423 | - | - | Completed | - | - |
| NCT03187093 | Major Depressive Disorder | Phase 4 | Recruiting | September 2018 | Ukraine ... more >> State Institution "Zaporizhzhia Medical Academy of Postgraduate Education Ministry of Health of Ukraine" Recruiting Zaporizhzhia, Ukraine, 69096 Contact: Alexandra Troyan, MD +380673287519 troian@zmapo.edu.ua Collapse << |
| NCT02072278 | Healthy Men | Phase 1 | Completed | - | France ... more >> FR801 Rennes, France, 35000 Collapse << |
| NCT00635219 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT01564862 | - | - | Completed | - | - |
| NCT01140906 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT02112903 | Healthy Women | Phase 1 | Completed | - | United Kingdom ... more >> GB801 London, United Kingdom, NW10 7EW Collapse << |
| NCT02709655 | Depressive Disorder, Major | Phase 3 | Recruiting | May 2021 | - |
| NCT01564862 | Depressive Disorder, Major | Phase 2 | Completed | - | - |
| NCT00811252 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT01395147 | Major Depressive Disorder | Phase 3 | Completed | - | Japan ... more >> Inzai-shi, Chiba, Japan Noda-City, Chiba, Japan Fukuoka-city, Fukuoka, Japan Kitakyushu-shi, Fukuoka, Japan Annaka-shi, Gunma, Japan Fujioka-shi, Gunma, Japan Takasaki-shi, Gunma, Japan Hatsukaichi-shi, Hiroshima, Japan Hiroshima-shi, Hiroshima, Japan Sapporo-Shi, Hokkaido, Japan Amagasaki-shi, Hyogo, Japan Kobe-shi, Hyogo, Japan Fujisawa-shi, Kanagawa, Japan Kawasaki-shi, Kanagawa, Japan Sagamihara-shi, Kanagawa, Japan Yokohama-shi, Kanagawa, Japan Osaka-shi, Kita-ku, Japan Kumamoto-shi, Kumamoto, Japan Kyoto-shi, Kyoto, Japan Kurashiki-shi, Okayama, Japan Osaka-shi, Osaka, Japan Fukaya-shi, Saitama, Japan Saitama-city, Saitama, Japan Utsunomiya-shi, Tochigi, Japan Anan-shi, Tokushima, Japan Tokushisma-shi, Tokushima, Japan Hachioji-shi, Tokyo, Japan Katsushika-ku, Tokyo, Japan Musashino-shi, Tokyo, Japan Nanyo-shi, Yamagata, Japan Ibaraki, Japan Tokyo, Japan Collapse << |
| NCT02389816 | Major Depressive Disorder | Phase 3 | Completed | - | Japan ... more >> Nagoya, Aichi, Japan Noda, Chiba, Japan Ruzan, Chiba, Japan Iizuka, Fukuoka, Japan Kitakyushu, Fukuoka, Japan Kurume, Fukuoka, Japan Kouriyama, Fukushima, Japan Shirakawa, Fukushima, Japan Sapporo, Hokkaido, Japan Ashiya, Hyogo, Japan Kanazawa, Ishikawa, Japan Kawasaki, Kanagawa, Japan Yokohama, Kanagawa, Japan Yokosuka, Kanagawa, Japan Kurashiki, Okayama, Japan Kadoma, Osaka, Japan Kita-ku, Osaka, Japan Osakasayama, Osaka, Japan Sakai, Osaka, Japan Karatsu, Saga, Japan Kawagoe, Saitama, Japan Kusatsu, Shiga, Japan Anan, Tokushima, Japan Arakawa-ku, Tokyo, Japan Chiyoda-ku, Tokyo, Japan Hachiouji, Tokyo, Japan Itabashi-ku, Tokyo, Japan Katsushika-ku, Tokyo, Japan Koutou-ku, Tokyo, Japan Meguro-ku, Tokyo, Japan Minato-ku, Tokyo, Japan Mitaka, Tokyo, Japan Musashino, Tokyo, Japan Nakano-ku, Tokyo, Japan Setagaya-ku, Tokyo, Japan Shibuya-ku, Tokyo, Japan Shinagawa-ku, Tokyo, Japan Shinjuku-ku, Tokyo, Japan Suginami-ku, Tokyo, Japan Taito-ku, Tokyo, Japan Toshima-ku, Tokyo, Japan Kofu, Yamanashi, Japan Fukuoka, Japan Hiroshima, Japan Kumamoto, Japan Okayama, Japan Saitama, Japan Collapse << |
| NCT00811252 | - | - | Completed | - | - |
| NCT01491035 | Depressive Disorder ... more >> Anxiety Disorder Collapse << | Phase 2 | Completed | - | United States, District of Col... more >>umbia US003 Washington, District of Columbia, United States, 20010 United States, Kansas US004 Wichita, Kansas, United States, 67214 United States, Ohio US002 Cincinnatti, Ohio, United States, 45219 US001 Cleveland, Ohio, United States, 44106 Germany DE002 Berlin, Germany, 10249 DE001 Mainz, Germany, 55122 DE003 Ulm, Germany, 89075 Collapse << |
| NCT00788034 | Generalized Anxiety Disorder | Phase 3 | Completed | - | - |
| NCT01491035 | - | - | Completed | - | - |
| NCT00635219 | - | - | Completed | - | - |
| NCT02749721 | Major Depressive Disorder | Phase 4 | Recruiting | February 2019 | United States, Illinois ... more >> Rush University Medical Center Recruiting Chicago, Illinois, United States, 60612 Contact: Linda Skaggs 312-942-5592 linda_skaggs@rush.edu Contact: Karen Neimanas 312-563-2595 karen_neimanas@rush.edu Principal Investigator: John Zajecka, MD Sub-Investigator: Corey Goldstein, MD Rush University Medical Center Recruiting Skokie, Illinois, United States, 60076 Contact: Linda Skaggs 312-942-5592 linda_skaggs@rush.edu Contact: Karen Neimanas 312-563-2595 karen_neimanas@rush.edu Collapse << |
| NCT01488071 | - | - | Completed | - | - |
| NCT01140906 | - | - | Completed | - | - |
| NCT00730691 | Generalized Anxiety Disorder | Phase 3 | Completed | - | - |
| NCT00596817 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT02919501 | Depressive Disorder, Major | Phase 2 | Completed | - | Estonia ... more >> EE1019 Tallinn, Estonia EE1020 Tallinn, Estonia Finland FI1040 Helsinki, Finland FI1041 Helsinki, Finland FI1030 Kuopio, Finland FI1009 Pori, Finland FI1027 Turku, Finland Collapse << |
| NCT01488071 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT00730691 | - | - | Completed | - | - |
| NCT02709746 | Depressive Disorder, Major | Phase 3 | Recruiting | April 2019 | - |
| NCT00596817 | - | - | Completed | - | - |
| NCT01571453 | - | - | Completed | - | - |
| NCT00672620 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT00672620 | - | - | Completed | - | - |
| NCT01571453 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT01422213 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT01422213 | - | - | Completed | - | - |
| NCT01153009 | Depressive Disorder, Major | Phase 3 | Completed | - | - |
| NCT02279966 | Major Depressive Disorder | Phase 3 | Completed | - | Estonia ... more >> EE001 Tallinn, Estonia EE002 Tallinn, Estonia EE004 Voru, Estonia Finland FI002 Helsinki, Finland FI003 Helsinki, Finland FI001 Kuopio, Finland FI008 Oulu, Finland FI007 Tampere, Finland Germany DE002 Berlin, Germany DE001 Bielefeld, Germany DE003 Frankfurt, Germany DE007 Frankfurt, Germany DE008 Schwerin, Germany Lithuania LT002 Kaunas, Lithuania LT006 Palanga, Lithuania LT003 Silute, Lithuania LT001 Vilnius, Lithuania LT005 Vilnius, Lithuania Collapse << |
| NCT02279953 | Major Depressive Disorder | Phase 3 | Completed | - | Estonia ... more >> EE001 Tallinn, Estonia EE002 Tallinn, Estonia Finland FI002 Helsinki, Finland FI003 Helsinki, Finland FI005 Helsinki, Finland FI001 Kuopio, Finland FI006 Kupio, Finland FI004 Turku, Finland Germany DE002 Berlin, Germany DE001 Bielefeld, Germany DE005 Bochum, Germany DE003 Frankfurt, Germany DE004 Mittweida, Germany Serbia RS002 Belgrade, Serbia RS001 Kragujevac, Serbia Slovakia SK003 Levice, Slovakia SK002 Rimavska Sobota, Slovakia Collapse << |
| NCT01153009 | - | - | Completed | - | - |
| NCT02395510 | Panic Disorder | Phase 4 | Completed | - | United States, California ... more >> Siyan Clinical Corporation Santa Rosa, California, United States, 95401 Collapse << |
| NCT00694304 | - | - | Completed | - | - |
| NCT00761306 | Major Depressive Disorder | Phase 2 | Completed | - | - |
| NCT00694304 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT02294305 | Social Anxiety Disorder ... more >> Major Depressive Disorder Collapse << | Phase 4 | Unknown | November 2016 | United States, New York ... more >> The Medical Research Network, LLC New York, New York, United States, 10128 Collapse << |
| NCT02637895 | Post-Traumatic Stress Disorder | Phase 4 | Recruiting | July 2019 | United States, Florida ... more >> University of Miami Recruiting Miami, Florida, United States, 33136 Contact: Cynthia Fundora, B.A 305-243-6127 cxf157@med.miami.edu Principal Investigator: Philip Harvey, PhD United States, Georgia Emory University Recruiting Atlanta, Georgia, United States, 30322 Contact: Andrea Wong 404-778-6663 andrea.wong@emory.edu Principal Investigator: Boadie W Dunlop, M.D Collapse << |
| NCT02386488 | Pharmacokinetics | Phase 1 | Completed | - | China ... more >> CB801 Chengdu, China Collapse << |
| NCT00761306 | - | - | Completed | - | - |
| NCT01364649 | - | - | Completed | - | - |
| NCT01364649 | Treatment Outcome | Phase 3 | Completed | - | - |
| NCT01323478 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT00735709 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT01323478 | - | - | Completed | - | - |
| NCT00735709 | - | - | Completed | - | - |
| NCT00731120 | Generalized Anxiety Disorder | Phase 3 | Completed | - | - |
| NCT00731120 | - | - | Completed | - | - |
| NCT00672958 | - | - | Completed | - | - |
| NCT00672958 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT03053362 | Major Depressive Disorder ... more >> Cognitive Change Collapse << | Phase 2 Phase 3 | Not yet recruiting | September 2018 | - |
| NCT00734071 | Generalized Anxiety Disorder | Phase 3 | Completed | - | - |
| NCT02327013 | - | - | Completed | - | - |
| NCT02327013 | Attention Deficit Hyperactivit... more >>y Disorder Collapse << | Phase 2 | Completed | - | United States, California ... more >> US015 Beverly Hills, California, United States US002 Garden Grove, California, United States US004 National City, California, United States United States, Florida US013 Bradenton, Florida, United States US006 Gainesville, Florida, United States United States, Georgia US010 Alpharetta, Georgia, United States United States, Illinois US014 Libertyville, Illinois, United States United States, Maryland US011 Baltimore, Maryland, United States United States, Massachusetts US009 Boston, Massachusetts, United States United States, Nevada US016 Las Vegas, Nevada, United States United States, New York US005 New York, New York, United States US008 New York, New York, United States United States, Texas US001 Austin, Texas, United States United States, Virginia US007 Herndon, Virginia, United States United States, Washington US003 Bellevue, Washington, United States Collapse << |
| NCT01255787 | Depressive Disorder, Major | Phase 2 Phase 3 | Completed | - | - |
| NCT00744627 | Generalized Anxiety Disorder | Phase 3 | Completed | - | - |
| NCT00744627 | - | - | Completed | - | - |
| NCT01163266 | Depressive Disorder, Major | Phase 3 | Completed | - | - |
| NCT01163266 | - | - | Completed | - | - |
| NCT01179516 | Depressive Disorder, Major | Phase 3 | Completed | - | - |
| NCT01179516 | - | - | Completed | - | - |
| NCT00734071 | - | - | Completed | - | - |
| NCT02528409 | Binge Eating Disorder | Phase 2 | Completed | - | United States, Illinois ... more >> University of Chicago Chicago, Illinois, United States, 60637 Collapse << |
| NCT01255787 | - | - | Completed | - | - |
| NCT03766867 | Major Depressive Disorder | Phase 2 | Recruiting | May 27, 2019 | Estonia ... more >> Tartu University Hospital (EE2002) Recruiting Tartu, Estonia Latvia Riga Centre of Psychiatry and Narcology (LV3002) Not yet recruiting Riga, Latvia Collapse << |
| NCT01299805 | Healthy | Phase 1 | Completed | - | United States, California ... more >> Glendale, California, United States Collapse << |
| NCT02272517 | Major Depressive Disorder | Phase 3 | Completed | - | Finland ... more >> FI005 Helsinki, Finland FI001 Kuopio, Finland FI006 Kupio, Finland FI007 Tampere, Finland FI004 Turku, Finland Germany DE005 Bochum, Germany DE004 Mittweida, Germany Serbia RS002 Belgrade, Serbia RS003 Belgrade, Serbia RS004 Belgrade, Serbia RS005 Belgrade, Serbia RS001 Kragujevac, Serbia Slovakia SK004 Bratislava, Slovakia SK001 Hronovce, Slovakia SK003 Levice, Slovakia SK002 Rimavska Sobota, Slovakia Collapse << |
| NCT02845349 | TBI Major Dep... more >>ression Collapse << | Phase 3 | Withdrawn(Funding withdrawn.) | October 2018 | - |
| NCT02637466 | Unipolar Major Depression ... more >> Stage I, II or III Breast Cancer Collapse << | Phase 4 | Withdrawn(Funding not received... more >>) Collapse << | July 2019 | - |
| NCT01676571 | Healthy | Phase 1 | Completed | - | China ... more >> CN001 Tianjin, China, 300457 Collapse << |
| NCT01299805 | - | - | Completed | - | - |
| NCT00707980 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT03437564 | Healthy Adult Participants | Phase 1 | Completed | - | Japan ... more >> Nishi Kumamoto Hospital Kumamoto, Japan Collapse << |
| NCT03272711 | Age-related Cognitive Decline | Phase 4 | Active, not recruiting | July 15, 2019 | United States, Missouri ... more >> Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Collapse << |
| NCT02454426 | Major Depressive Disorder ... more >> Coronary Artery Disease Collapse << | Early Phase 1 | Withdrawn(PI left institution) | - | United States, Pennsylvania ... more >> Thomas Jefferson University Philadelphia, Pennsylvania, United States, 19107 Collapse << |
| NCT01607125 | Depression | Phase 1 | Completed | - | United Kingdom ... more >> GB001 Headington, United Kingdom, OX3 7JX Collapse << |
| NCT01355081 | - | - | Completed | - | - |
| NCT03580967 | Type2 Diabetes ... more >> Major Depressive Disorder Collapse << | Phase 4 | Not yet recruiting | August 1, 2023 | United States, Illinois ... more >> Loyola University Medical Center Not yet recruiting Maywood, Illinois, United States, 60153 Contact: Todd Doyle, PhD 708-216-4303 todddoyle1@lumc.edu Collapse << |
| NCT01152996 | - | - | Completed | - | - |
| NCT00707980 | - | - | Completed | - | - |
| NCT01355081 | Major Depressive Disorder | Phase 3 | Completed | - | Japan ... more >> Inzai-shi, Chiba, Japan Noda-City, Chiba, Japan Fukuoka-city, Fukuoka, Japan Kitakyushu-shi, Fukuoka, Japan Annaka-shi, Gunma, Japan Fujioka-shi, Gunma, Japan Takasaki-shi, Gunma, Japan Hatsukaichi-shi, Hiroshima, Japan Hiroshima-shi, Hiroshima, Japan Sapporo-Shi, Hokkaido, Japan Amagasaki-shi, Hyogo, Japan Kobe-shi, Hyogo, Japan Fujisawa-shi, Kanagawa, Japan Kawasaki-shi, Kanagawa, Japan Sagamihara-shi, Kanagawa, Japan Yokohama-shi, Kanagawa, Japan Osaka-shi, Kita-ku, Japan Kumamoto-shi, Kumamoto, Japan Kyoto-shi, Kyoto, Japan Kurashiki-shi, Okayama, Japan Osaka-shi, Osaka, Japan Fukaya-shi, Saitama, Japan Saitama-city, Saitama, Japan Utsunomiya-shi, Tochigi, Japan Anan-shi, Tokushima, Japan Tokushisma-shi, Tokushima, Japan Hachioji-shi, Tokyo, Japan Katsushika-ku, Tokyo, Japan Musashino-shi, Tokyo, Japan Nanyo-shi, Yamagata, Japan Ibaraki, Japan Tokyo, Japan Collapse << |
| NCT02932904 | Healthy Volunteers | Phase 4 | Completed | - | United States, California ... more >> Encino, California, United States Long Beach, California, United States Torrance, California, United States United States, Florida Jacksonville, Florida, United States Orlando, Florida, United States United States, Georgia Atlanta, Georgia, United States Decatur, Georgia, United States United States, Missouri Saint Louis, Missouri, United States United States, Nevada Las Vegas, Nevada, United States United States, Oregon Portland, Oregon, United States United States, Texas Austin, Texas, United States Dallas, Texas, United States San Antonio, Texas, United States United States, Virginia Charlottesville, Virginia, United States United States, Washington Seattle, Washington, United States Collapse << |
| NCT02357797 | Schizophrenia ... more >> Negative Symptoms Collapse << | Phase 4 | Recruiting | March 2020 | United States, New York ... more >> The Zucker Hillside Hospital Recruiting Glen Oaks, New York, United States, 11004 Contact: Christoph U Correll, MD 718-470-4812 ccorrell@nshs.edu Collapse << |
| NCT02932904 | - | - | Completed | - | - |
| NCT02969876 | Depressive Disorder ... more >> Major Depression Depression Depression, Unipolar Collapse << | Phase 4 | Recruiting | November 2018 | United States, Massachusetts ... more >> the Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Kyle Palmstrom, B.S. 617-724-9458 kpalmstrom@mgh.harvard.edu Principal Investigator: Andrew Nierenberg, M.D. Collapse << |
| NCT02234362 | - | - | Completed | - | - |
| NCT02332954 | Major Depressive Disorder | Phase 4 | Completed | - | Canada, Alberta ... more >> CA004 Edmonton, Alberta, Canada, T6L 6W6 Canada, British Columbia CA005 Kelowna, British Columbia, Canada, V1Y 1Z9 Canada, Newfoundland and Labrador CA006 St. John's, Newfoundland and Labrador, Canada, A1E 2C2 Canada, Nova Scotia CA007 Halifax, Nova Scotia, Canada, B3S 1M7 Canada, Ontario CA016 Burlington, Ontario, Canada, L7R 4E2 CA013 Chatham, Ontario, Canada, N7L 1C1 CA010 Corunna, Ontario, Canada, N0N 1G0 CA012 Fort Erie, Ontario, Canada, L2A 1Z3 CA017 Hamilton, Ontario, Canada, L8M 1K7 CA026 Hamilton, Ontario, Canada, L8N 4A6 CA011 London, Ontario, Canada, N6H 4P2 CA003 Mississauga, Ontario, Canada, L5M 4N4 CA008 Sarnia, Ontario, Canada, N7T 4X3 CA009 Sarnia, Ontario, Canada, N7T 4X3 CA015 St. Catharines, Ontario, Canada, L2T 3Y4 Canada, Quebec CA022 Montreal, Quebec, Canada, H1N 3V2 CA020 Montreal, Quebec, Canada, H2R 1V6 CA023 Montreal, Quebec, Canada, H3A 0G6 CA018 Pointe-Claire, Quebec, Canada, H9R 4S3 CA024 St-Jean-sur-Richelieu, Quebec, Canada, J2W 1J1 CA030 Victoriaville, Quebec, Canada, G6P 6P6 CA027 Westmount, Quebec, Canada, H4A1S9 Canada, Saskatchewan CA028 Saskatoon, Saskatchewan, Canada, S7K 3H3 Canada CA019 Quebec, Canada, G1G 3Y8 CA021 Quebec, Canada, G3K 2P8 CA029 Quebec, Canada, G3K 2P8 Collapse << |
| NCT01152996 | Depressive Disorder, Major | Phase 3 | Completed | - | - |
| NCT03555136 | - | - | Recruiting | June 30, 2020 | United States, Missouri ... more >> US 0039 Mattingly Recruiting Saint Charles, Missouri, United States, 63304 Contact: Email Contact via H. Lundbeck A/S Collapse << |
| NCT02871297 | Depressive Disorder, Major | Phase 3 | Enrolling by invitation | September 2019 | - |
| NCT03108625 | Depressive Disorder, Major | Phase 3 | Active, not recruiting | May 2020 | - |
| NCT02170220 | Severe Hepatic Impairment | Phase 1 | Completed | - | United States, Florida ... more >> University of Miami Miami, Florida, United States Collapse << |
| NCT02371980 | Major Depressive Disorder | Phase 4 | Active, not recruiting | May 1, 2019 | - |
| NCT02972632 | Major Depressive Disorder | Phase 4 | Completed | - | United States, California ... more >> ATP Clinical Research, Inc. Costa Mesa, California, United States, 92626 ProScience Research Group Culver City, California, United States, 90230 Behavioral Research Specialists, LLC Glendale, California, United States, 91206 Pacific Research Partners Oakland, California, United States, 94607 Excell Research Oceanside, California, United States, 92056 Anderson Clinical Research Redlands, California, United States, 92374 University Medical Group Upland, California, United States, 91207 United States, Colorado MCB Clinical Research Centers, LLC Colorado Springs, Colorado, United States, 80910 United States, Florida Suncoast Clinical Research Inc. New Port Richey, Florida, United States, 34652 Behavioral Clinical Research , Inc North Miami, Florida, United States, 33162 Compass Research Main Orlando, Florida, United States, 32806 University of South Florida Tampa, Florida, United States, 33613 United States, Illinois Great Lakes Clinical Trials Chicago, Illinois, United States, 60640 Baber Research Group Naperville, Illinois, United States, 60563 United States, Indiana Deaconess Clinic Evansville, Indiana, United States, 47713-1227 United States, Massachusetts Novex Clinical Research, LLC New Bedford, Massachusetts, United States, 2740 Coastal Research Associates, Inc. South Weymouth, Massachusetts, United States, 2190 United States, Michigan University of Michigan, Ann Arbor Ann Arbor, Michigan, United States, 48109 United States, New York Columbia University Medical Center New York, New York, United States, 10023 United States, Ohio Dayton Clinical Research Dayton, Ohio, United States, 45406 United States, Pennsylvania Green & Seidner Family Practice Associates Lansdale, Pennsylvania, United States, 19446 United States, Texas Relaro Medical Trials Dallas, Texas, United States, 75243 Red Oak Psychiatry Associates, PA Houston, Texas, United States, 77090 Radiant Research, Inc. San Antonio, Texas, United States, 78229 Family Psychiatry of The Woodlands The Woodlands, Texas, United States, 77381 Collapse << |
| NCT02234362 | Depression Me... more >>nopause Vasomotor Disturbance Hot Flashes Sleep Collapse << | Phase 4 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Collapse << |
| NCT03598868 | Bipolar Disorder Depression | Phase 2 | Recruiting | September 25, 2021 | Korea, Republic of ... more >> Inha University Hospital Not yet recruiting Incheon, Korea, Republic of Contact: Hyeyoung Kim, MD Seoul National University Hospital Recruiting Seoul, Korea, Republic of Contact: Yong Min Ahn, MD. PHD Collapse << |
| NCT02170220 | - | - | Completed | - | - |
| 靶点 | Description | IC50 |
|---|---|---|
| SERT | IC50:1.6nM | |
| 5-HT Receptor 1A | IC50:15nM | |
| 5-HT Receptor 7 | IC50:19nM | |
| 5-HT Receptor 3A | IC50:3.7nM | |
| 5-HT Receptor 1B | IC50:33nM |
